A heparin‐binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG‐M/versican

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

2007 • 11,720 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis

1992 • 1,259 citations

Deglycosylation of glycoproteins by trifluoromethanesulfonic acid

1981 • 728 citations

Structural Basis for FGF Receptor Dimerization and Activation

1999 • 597 citations

Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

1999 • 487 citations

cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis

1988 • 479 citations

Cloning and Expression of a Developmentally Regulated Protein That Induces Mitogenic and Neurite Outgrowth Activity

1990 • 468 citations

More to “heparin” than anticoagulation

1994 • 346 citations

A Receptor-like Protein-tyrosine Phosphatase PTPζ/RPTPβ Binds a Heparin-binding Growth Factor Midkine

1999 • 305 citations

Culture from mouse bone marrow of a subclass of mast cells possessing a distinct chondroitin sulfate proteoglycan with glycosaminoglycans rich in N-acetylgalactosamine-4,6-disulfate.

1982 • 282 citations

Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).

1994 • 281 citations

Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis

1995 • 278 citations

6B4 Proteoglycan/Phosphacan, an Extracellular Variant of Receptor-like Protein-tyrosine Phosphatase ζ/RPTPβ, Binds Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM)

1996 • 277 citations

Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis

1994 • 264 citations

Molecular cloning of the 18-kDa growth-associated protein of developing brain.

1990 • 255 citations

Bovine CNS Myelin Contains Neurite Growth-Inhibitory Activity Associated with Chondroitin Sulfate Proteoglycans

1999 • 249 citations

A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis.

1990 • 249 citations

Midkine, A Retinoic Acid-Inducible Growth/Differentiation Factor: Immunochemical Evidence for the Function and Distribution

1993 • 229 citations

Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration

1998 • 219 citations

Purification of recombinant midkine and examination of its biological activities: Functional comparison of new heparin binding factors

1991 • 206 citations

A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo.

1986 • 204 citations

A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.

1987 • 192 citations

High Affinity Binding and Overlapping Localization of Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β with Tenascin-R, Amphoterin, and the Heparin-binding Growth-associated Molecule

1998 • 189 citations

Neointima formation in a restenosis model is suppressed in midkine-deficient mice

2000 • 187 citations

Midkine Inhibits Caspase‐Dependent Apoptosis via the Activation of Mitogen‐Activated Protein Kinase and Phosphatidylinositol 3‐Kinase in Cultured Neurons

1999 • 184 citations

Analysis of unsaturated disaccharides from glycosaminoglycuronan by high-performance liquid chromatography

1989 • 180 citations

A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product.

1990 • 178 citations

Multiple Forms of Mouse PG-M, a Large Chondroitin Sulfate Proteoglycan Generated by Alternative Splicing

1995 • 169 citations

Midkine, a Retinoic Acid-Inducible Heparin-Binding Cytokine in Inflammatory Responses: Chemotactic Activity to Neutrophils and Association with Inflammatory Synovitis

1997 • 158 citations

Solution structure of midkine, a new heparin-binding growth factor

1997 • 152 citations

Midkine Enhances Fibrinolytic Activity of Bovine Endothelial Cells

1995 • 122 citations

Heparin-binding Growth-associated Molecule Contains Two Heparin-binding β-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat

2000 • 108 citations

A monoclonal antibody that specifically recognizes a glucuronic acid 2-sulfate-containing determinant in intact chondroitin sulfate chain.

1987 • 99 citations

Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican

1994 • 99 citations

Changes in glycosaminoglycan biosynthesis during differentiation in vitro of human monocytes

1983 • 99 citations

Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch)

1997 • 98 citations

Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine.

1997 • 96 citations

Tissue variation of two large chondroitin sulfate proteoglycans (PG-M/versican and PG-H/aggrecan) in chick embryos

1993 • 96 citations

Inhibitory effects of PG‐H/aggrecan and PG‐M/versican on avian neural crest cell migration

1996 • 89 citations

Midkine, a Heparin-Binding Growth/Differentiation Factor, Exhibits Nerve Cell Adhesion and Guidance Activity for Neurite Outgrowth In Vitro

1996 • 76 citations

Midkine Induces Tumor Cell Proliferation and Binds to a High Affinity Signaling Receptor Associated with JAK Tyrosine Kinases

1998 • 64 citations

Absence of keratan sulphate from skeletal tissues of mouse and rat

1985 • 60 citations

The Gene Structure and Organization of Mouse PG-M, a Large Chondroitin Sulfate Proteoglycan

1995 • 60 citations

Identification and characterization of ligands for L-selectin in the kidney. I. Versican, a large chondroitin sulfate proteoglycan, is a ligand for L-selectin

1999 • 59 citations

Localization of Heparin-Binding, Neurite Outgrowth and Antigenic Regions in Midkine Molecule

1994 • 58 citations

The large chondroitin sulphate proteoglycan versican in mammalian vitreous

1998 • 52 citations

Articular cartilage proteoglycans from normal and osteoarthritic mice

1986 • 43 citations

Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity

1998 • 37 citations

Synthesis of chondroitin sulfate D and heparin proteoglycans in murine lymph node-derived mast cells. The dependence on fibroblasts.

1990 • 34 citations

Structural Characteristics of Heparin-like Domain Required for Interaction of Midkine with Embryonic Neurons

1996 • 34 citations

Biosynthesis of glycosaminoglycans in peritoneal macrophages from the guinea pig

1982 • 25 citations