Cardiovascular Basic Helix Loop Helix Factor 1, a Novel Transcriptional Repressor Expressed Preferentially in the Developing and Adult Cardiovascular System

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.

1997 • 1,138 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.

1997 • 1,031 citations

Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

1997 • 1,024 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Identification of neurogenin, a Vertebrate Neuronal Determination Gene

1996 • 821 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

1997 • 778 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

Fashioning the vertebrate heart: earliest embryonic decisions

1997 • 490 citations

Defining the regulatory networks for muscle development

1996 • 458 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

SM22α, a Marker of Adult Smooth Muscle, Is Expressed in Multiple Myogenic Lineages During Embryogenesis

1996 • 397 citations

Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

1994 • 395 citations

Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.

1994 • 392 citations

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

1998 • 375 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse

1998 • 325 citations

Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates

1998 • 299 citations

Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation.

1994 • 252 citations

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

1993 • 242 citations

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.

1994 • 233 citations

Specificity for the Hairy/Enhancer of split Basic Helix-Loop-Helix (bHLH) Proteins Maps outside the bHLH Domain and Suggests Two Separable Modes of Transcriptional Repression

1995 • 223 citations

The function of hairy-related bHLH repressor proteins in cell fate decisions

1998 • 218 citations

MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD

1999 • 169 citations

Parsing the Heart: Genetic Modules for Organ Assembly

1997 • 163 citations

Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.

1995 • 103 citations

Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells

1996 • 94 citations

An In Vitro Assay of β-Galactosidase from Yeast

1996 • 81 citations

Enhancement of Serum-response Factor-dependent Transcription and DNA Binding by the Architectural Transcription Factor HMG-I(Y)

1998 • 68 citations

Embryonic Expression Suggests an Important Role for CRP2/SmLIM in the Developing Cardiovascular System

1998 • 66 citations

In Vitro System for Differentiating Pluripotent Neural Crest Cells into Smooth Muscle Cells

1998 • 61 citations

Generation of a Dominant-negative Mutant of Endothelial PAS Domain Protein 1 by Deletion of a Potent C-terminal Transactivation Domain

1999 • 60 citations

Altered expression of helix-loop-helix transcriptional regulators and cyclin D1 in Wnt-1-transformed PC12 cells.

1998 • 25 citations

The Polymyositis-Scleroderma Autoantigen Interacts with the Helix-Loop-Helix Proteins E12 and E47

1997 • 24 citations