The Basic Helix-Loop-Helix Transcription factorsdHAND and eHAND Exhibit Dimerization Characteristics That Suggest Complex Regulation of Function

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Genomic Libraries and a Host Strain Designed for Highly Efficient Two-Hybrid Selection in Yeast

1996 • 2,631 citations

Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms

2000 • 1,761 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

1997 • 716 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

A Subclass of bHLH Proteins Required for Cardiac Morphogenesis

1995 • 544 citations

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

1998 • 524 citations

Basic helix-loop-helix genes in neural development

1997 • 521 citations

Molecular Pathways Controlling Heart Development

1996 • 485 citations

Defining the regulatory networks for muscle development

1996 • 458 citations

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

1998 • 375 citations

The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development

2000 • 330 citations

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1995 • 321 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

HRT1, HRT2, and HRT3: A New Subclass of bHLH Transcription Factors Marking Specific Cardiac, Somitic, and Pharyngeal Arch Segments

1999 • 276 citations

Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.

1991 • 275 citations

Expression of the Novel Basic Helix-Loop-Helix Gene eHAND in Neural Crest Derivatives and Extraembryonic Membranes during Mouse Development

1995 • 248 citations

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development

2000 • 246 citations

The HAND1 Basic Helix-Loop-Helix Transcription Factor Regulates Trophoblast Differentiation via Multiple Mechanisms

2000 • 227 citations

MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains

1997 • 196 citations

Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway

2000 • 172 citations

Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain.

1996 • 145 citations

Identification and Expression of a Novel Family of bHLH cDNAs Related to Drosophila Hairy and Enhancer of Split

1999 • 141 citations

Voltage-Gated K⁺Channel β Subunits: Expression and Distribution of Kvβ1 and Kvβ2 in Adult Rat Brain

1996 • 135 citations

MEF2B Is a Potent Transactivator Expressed in Early Myogenic Lineages

1996 • 135 citations

The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD

1998 • 120 citations

Characterization of the Human and Mouse HEY1, HEY2, and HEYL Genes: Cloning, Mapping, and Mutation Screening of a New bHLH Gene Family

2000 • 87 citations

Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.

1991 • 81 citations

Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.

1993 • 58 citations

ME1 and GE1: Basic Helix – Loop – Helix Transcription Factors Expressed at High Levels in the Developing Nervous System and in Morphogenetically Active Regions

1993 • 56 citations

Kinetics of E2A basic helix-loop-helix-protein expression during myelopoiesis and primary B cell differentiation.

1993 • 28 citations

Combinatorial Interactions Regulate Cardiac Expression of the Murine Adenylosuccinate Synthetase 1 Gene

1999 • 14 citations