The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

Basic local alignment search tool

1990 • 87,358 citations

Normal Table of Xenopus Laevis (Daudin)

1958 • 4,561 citations

Normal table of Xenopus laevis (Daudin)

1995 • 2,955 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos

1988 • 521 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

Control of C. elegans Larval Development by Neuronal Expression of a TGF-β Homolog

1996 • 516 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction

1987 • 485 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Processed Vg1 protein is an axial mesoderm inducer in xenopus

1993 • 417 citations

Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

1995 • 415 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells.

1992 • 395 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

A simple, rapid method for the purification of poly A+ RNA.

1988 • 382 citations

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1993 • 368 citations

Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

1993 • 365 citations

Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons

1996 • 359 citations

Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration

1984 • 353 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4

1995 • 344 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

Neural crest development in the Xenopus laevis embryo, studied by interspecific transplantation and scanning electron microscopy

1987 • 297 citations

Early cellular interactions promote embryonic axis formation in Xenopus laevis

1984 • 291 citations

Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication

1994 • 267 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

Localized BMP-4 Mediates Dorsal/Ventral Patterning in the Early Xenopus Embryo

1995 • 229 citations

Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells

1992 • 190 citations

Vital dye labelling of Xenopus laevis trunk neural crest reveals multipotency and novel pathways of migration

1993 • 183 citations

Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols.

1991 • 173 citations

Xnr4:AXenopusNodal-Related Gene Expressed in the Spemann Organizer

1997 • 159 citations

A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration

1991 • 147 citations

Development of the Xenopus Pronephric System

1995 • 138 citations

BMP-2 and BMP-4, but Not BMP-6, Increase the Number of Adrenergic Cells Which Develop in Quail Trunk Neural Crest Cultures

1996 • 133 citations

Growth factors in development: the role of TGF-β related polypeptide signalling molecules in embryogenesis

1994 • 124 citations

Identification of drm, a Novel Gene Whose Expression Is Suppressed in Transformed Cells and Which Can Inhibit Growth of Normal but Not Transformed Cells in Culture

1997 • 118 citations

Posterior expression of a homeobox gene in early Xenopus embryos

1987 • 117 citations

Lineage Diversification of the Neural Crest: In Vitro Investigations

1993 • 108 citations

Number of adrenergic and Islet‐1 immunoreactive cells is increased in avian trunk neural crest cultures in the presence of human recombinant osteogenic protein‐1

1995 • 105 citations

ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin

1992 • 105 citations

Bone morphogenetic protein 2 in the early development of Xenopus laevis

1995 • 103 citations

Mapping of neural crest pathways in Xenopus laevis using inter- and intra-specific cell markers

1988 • 81 citations

Molecular cloning and characterization of a cDNA showing negative regulation in v-src-transformed 3Y1 rat fibroblasts.

1993 • 70 citations

Bone morphogenetic protein-4

1996 • 59 citations

Induction of Axial Mesoderm by zDVR-1, the Zebrafish Orthologue ofXenopusVg1

1996 • 57 citations

Tumor-suppressive activity of N03 gene product in v-src-transformed rat 3Y1 fibroblasts.

1994 • 56 citations

Segregation of cell lineage in the neural crest

1993 • 44 citations

Overexpression of DAN gene product in normal rat fibroblasts causes a retardation of the entry into the S phase.

1995 • 41 citations

Axis duplication and anterior identity in the mouse embryo.

1997 • 36 citations

Cloning of Mouse DAN cDNA and Its Down‐regulation in Transformed Cells

1996 • 20 citations