Modeling stochastic gene expression: Implications for haploinsufficiency

Numerical recipes in C

1994 • 15,831 citations

Stochastic mechanisms in gene expression

1997 • 1,860 citations

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

1997 • 1,239 citations

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

1997 • 1,121 citations

Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats

1993 • 1,067 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Single channel recording

1984 • 981 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

SOX10 mutations in patients with Waardenburg-Hirschsprung disease

1998 • 806 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1994 • 702 citations

Harrison's principles of internal medicine

1971 • 674 citations

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

1997 • 574 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

DiGeorge syndrome: part of CATCH 22.

1993 • 510 citations

Transcription complex stability and chromatin dynamics in vivo

1995 • 488 citations

Quantitative modeling of stochastic systems in molecular biology by using stochastic Petri nets

1998 • 417 citations

Enhancers increase the probability but not the level of gene expression.

1995 • 293 citations

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

1990 • 292 citations

A stochastic model for gene induction

1991 • 198 citations

The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.

1990 • 194 citations

Human haploinsufficiency — one for sorrow, two for joy

1994 • 192 citations

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

1997 • 168 citations

Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease

1993 • 140 citations

Formation of stable transcription complexes as assayed by analysis of individual templates.

1988 • 118 citations

Problems and paradigms: Induction mechanism of a single gene molecule: Stochastic or deterministic?

1992 • 114 citations

Differentiation in mouse melanoma cells: Initial reversibility and an on-off stochastic model

1983 • 107 citations

Analyses of loss-of-function mutations of the MITF gene suggest that haploinsufficiency is a cause of Waardenburg syndrome type 2A.

1996 • 107 citations

A novel germ line mutation in SOX9 causes familial campomelic dysplasia and sex reversal

1996 • 87 citations

A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome

1993 • 48 citations

The initiation of hepatocyte-specific gene expression within embryonic hepatocytes is a stochastic event

1989 • 36 citations

The expression of liver-specific genes within rat embryonic hepatocytes is a discontinuous process

1994 • 20 citations