Tgf-β and the Smad Pathway in Liver Fibrogenesis

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

TGF‐β signaling and the fibrotic response

2004 • 2,195 citations

Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury

2000 • 2,078 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

2003 • 1,308 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Roles of TGF-beta in hepatic fibrosis

2002 • 794 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

TGF-β and fibrosis

1999 • 579 citations

Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

2001 • 571 citations

Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

2000 • 563 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

Effect of antioxidants, resveratrol, quercetin, andN-acetylcysteine, on the functions of cultured rat hepatic stellate cells and kupffer cells

1998 • 406 citations

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

1999 • 400 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Mechanisms of TGF-β-mediated apoptosis

2002 • 397 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats

2001 • 373 citations

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

2003 • 364 citations

Transforming growth factor β and the liver

2001 • 340 citations

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

1999 • 325 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Latent transforming growth factor-β binding proteins (LTBPs)—structural extracellular matrix proteins for targeting TGF-β action

1999 • 302 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis

1996 • 289 citations

Transforming growth factor beta signal transduction.

2002 • 270 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

Latency, activation, and binding proteins of TGF-?

2001 • 262 citations

The role of Smad3 in mediating mouse hepatic stellate cell activation

2001 • 253 citations

Role of hydrogen peroxide and oxidative stress in healing responses

2002 • 253 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Transforming Growth Factor-β-induced Apoptosis Is Mediated by Smad-dependent Expression of GADD45b through p38 Activation

2003 • 249 citations

p38 MAPK mediates fibrogenic signal through smad3 phosphorylation in rat myofibroblasts

2003 • 248 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Inhibition of transforming growth factorβ prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

2000 • 243 citations

Effects of sho-saiko-to, a japanese herbal medicine, on hepatic fibrosis in rats

1999 • 240 citations

Transforming growth factor β₁induces the expression of α1(i) procollagen mRNA by a hydrogen peroxide-C/EBPβ-dependent mechanism in rat hepatic stellate cells

1999 • 237 citations

Molecular Mechanisms of Liver Fibrogenesis – A Homage to the Role of Activated Fat-Storing Cells

1995 • 237 citations

Modulation of transforming growth factorβ response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts

2000 • 225 citations

A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C

1997 • 224 citations

Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex

2000 • 223 citations

Bone Morphogenetic Protein-7 Improves Renal Fibrosis and Accelerates the Return of Renal Function

2002 • 222 citations

Hierarchical model of gene regulation by transforming growth factor β

2003 • 209 citations

The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts

1998 • 202 citations

New aspects of hepatic fibrosis

2000 • 199 citations

Transforming growth factor β signal transduction

2002 • 194 citations

Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts

2001 • 187 citations

Smads 2 and 3 Are Differentially Activated by Transforming Growth Factor-β (TGF-β) in Quiescent and Activated Hepatic Stellate Cells

2003 • 185 citations

Inhibition of rat hepatic lipocyte activation in culture by interferon-γ

1992 • 185 citations

A role for MEK kinase 1 in TGF- /activin-induced epithelium movement and embryonic eyelid closure

2003 • 176 citations

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

2002 • 169 citations

Effect of transforming growth factor beta on cell death of cultured rat hepatocytes.

1991 • 166 citations

Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis

2001 • 164 citations

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: Implications for antifibrotic therapy

2002 • 163 citations

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-β1

1999 • 159 citations

Proteolytic control of growth factor availability

1999 • 157 citations

Autocrine Transforming Growth Factor-β Signaling Mediates Smad-independent Motility in Human Cancer Cells

2003 • 157 citations

Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats

1998 • 155 citations

Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats

1996 • 151 citations

Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-β Signaling in Activated Rat Hepatic Stellate Cells

1999 • 150 citations

Transforming Growth Factor-β Induces Renal Epithelial Jagged-1 Expression in Fibrotic Disease

2002 • 144 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

A Soluble Transforming Growth Factor beta Receptor Expressed in Muscle Prevents Liver Fibrogenesis and Dysfunction in Rats

2000 • 138 citations

p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts

2003 • 133 citations

Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats

1996 • 130 citations

Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-β

2001 • 126 citations

Hepatic fibrosis as wound repair: A progress report

1998 • 123 citations

A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

2003 • 118 citations

Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells

2001 • 113 citations

Role of transforming growth factor ? type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats

1999 • 107 citations

TGF-β1: immunosuppressant and viability factor for T lymphocytes

1999 • 105 citations

The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity

1997 • 99 citations

A blocking peptide for transforming growth factor-β1 activation prevents hepatic fibrosis in vivo

2003 • 93 citations

TGF-β-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes

1997 • 93 citations

Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats

2003 • 84 citations

Transforming growth factor-β1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity

1998 • 84 citations

Lefty Inhibits Receptor-regulated Smad Phosphorylation Induced by the Activated Transforming Growth Factor-β Receptor

2001 • 80 citations

Smad6 functions as an intracellular antagonist of some TGF‐β family members during Xenopus embryogenesis

1998 • 78 citations

(Latent) transforming growth factor ? in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells

1998 • 71 citations

Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor ?

1996 • 68 citations

Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis

2001 • 67 citations

Antisense Oligonucleotides Against Thrombospondin-1 Inhibit Activation of TGF-β in Fibrotic Renal Disease in the Rat in Vivo

2003 • 64 citations

Receptor regulated SMADS in TGF beta signaling

2003 • 58 citations

Adenoviral delivery of an antisense RNA complementary to the 3' coding sequence of transforming growth factor-beta1 inhibits fibrogenic activities of hepatic stellate cells.

2002 • 57 citations

The virtuosity of hepatic stellate cells

1999 • 55 citations

Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture

2001 • 54 citations

Role of NK cells and TGF-β in the regulation of T-cell-dependent antibody production in health and autoimmune disease

1999 • 54 citations

Molecular and functional aspects of latent transforming growth factor-β binding protein: just a masking protein?

1999 • 48 citations

Transforming growth factor-β1 downregulation of Smad1 gene expression in rat hepatic stellate cells

2003 • 48 citations

Inhibition of rat hepatocyte proliferation by transforming growth factor ? and glucagon is associated with inhibition of ERK2 and p70 S6 kinase

1999 • 47 citations

Expression of different isoforms of TGF-β and the latent TGF-β binding protein (LTBP) by rat Kupffer cells

1998 • 44 citations

Inhibitory effect of a soluble transforming growth factor β type II receptor on the activation of rat hepatic stellate cells in primary culture

2003 • 44 citations

Analysis of the expression pattern of the latent transforming growth factor ? binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region

1998 • 42 citations

Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

2001 • 36 citations

Expression of isoforms and splice variants of the latent transforming growth factor β binding protein (LTBP) in cultured human liver myofibroblasts

2001 • 33 citations

Regulation of Cell Cycle-Related Genes in Rat Hepatocytes by Transforming Growth Factor β1

1997 • 31 citations

Expression and release of the latent transforming growth factor ? binding protein by hepatocytes from rat liver

1997 • 26 citations

Decorin transfection in human mesangial cells downregulates genes playing a role in the progression of fibrosis

2002 • 22 citations

The tightrope of therapeutic suppression of active transforming growth factor-β: high enough to fall deeply?

2003 • 19 citations

Interleukin-6 induces thermotolerance in cultured Caco-2 cells independent of the heat shock response

2003 • 19 citations

α₂‐Macroglobulin reduces paracrine‐ and autocrine‐stimulated matrix synthesis of cultured rat hepatic stellate cells

1999 • 16 citations

Divergence of TGFβ signaling in activated hepatic stellate cells downstream from Smad2 phosphorylation

2002 • 11 citations