Analysis of the expression pattern of the latent transforming growth factor ? binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region

Basic local alignment search tool

1990 • 87,358 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Hepatogastroenterology

2011 • 1,052 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene.

1988 • 462 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

CHARACTERISATION OF A NEW SUBGROUP OF AUTOIMMUNE CHRONIC ACTIVE HEPATITIS BY AUTOANTIBODIES AGAINST A SOLUBLE LIVER ANTIGEN

1987 • 418 citations

Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells

1995 • 398 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices

1994 • 386 citations

Fibrillin-1: Organization in Microfibrils and Structural Properties

1996 • 246 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Role of Transforming Growth Factor- in Tissue Injury and Repair

1997 • 237 citations

Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

1996 • 236 citations

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

1992 • 230 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Transforming growth factor—beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers

1995 • 219 citations

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin.

1992 • 204 citations

Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.

1994 • 192 citations

Bovine Latent Transforming Growth Factor β1-Binding Protein 2: Molecular Cloning, Identification of Tissue Isoforms, and Immunolocalization to Elastin-Associated Microfibrils

1995 • 186 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3)

1995 • 147 citations

Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation

1993 • 137 citations

Extracellular Fibrillar Structure of Latent TGFβ Binding Protein-1: Role in TGFβ-dependent Endothelial-Mesenchymal Transformation during Endocardial Cushion Tissue Formation in Mouse Embryonic Heart

1997 • 123 citations

Insulinlike growth factor—ii/mannose 6-phosphate receptor is expressed on ccl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells

1995 • 121 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

1993 • 114 citations

Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2

1994 • 93 citations

Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor-β Binding Protein with the Extracellular Matrix

1995 • 89 citations

Endoscopic Management of Biliary Tract Strictures in Primary Sclerosing Cholangitis

1996 • 86 citations

Sequence and expression of a novel member (LTBP‐4) of the family of latent transforming growth factor‐β binding proteins

1997 • 81 citations

The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture

1993 • 66 citations

Transforming growth factor β (TGF-β) expression in isolated and cultured rat hepatocytes

1996 • 57 citations

Isoforms and splice variant of transforming growth factor β–binding protein in rat hepatic stellate cells

1998 • 52 citations

Expression of hepatocyte growth factor, transforming growth factor ?, and transforming growth factor ? 1 messenger RNA in various human liver diseases and correlation with hepatocyte proliferation

1996 • 50 citations

Attenuation of TGF-β-Induced Apoptosis in Primary Cultures of Hepatocytes by Calpain Inhibitors

1997 • 44 citations

Mediators of hepatic fibrogenesis.

1996 • 43 citations

Clinical relevance of mutations in the precore genome of the hepatitis B virus.

1995 • 38 citations

Characterization and regulation of the latent transforming growth factor-β complex secreted by vascular pericytes

1996 • 33 citations

Matrix-associated latent TGF-beta with latent TGF-beta binding protein in the progressive process in adriamycin-induced nephropathy.

1995 • 26 citations

Expression and release of the latent transforming growth factor ? binding protein by hepatocytes from rat liver

1997 • 26 citations

Variation of immunocytochemical expression of transforming growth factor (TGF)-β in hepatocytes in culture and liver slices

1996 • 22 citations

Insulinlike growth factor-II/mannose 6-phosphate receptor is expressed on cc14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-? in cocultures with sinusoidal endothelial cells*1

1995 • 15 citations