Transforming growth factor β and the liver

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta

2011 • 1,990 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Controlling TGF-beta signaling.

2000 • 1,806 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

1997 • 1,376 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Hepatocyte growth factor gene therapy of liver cirrhosis in rats

1999 • 587 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

1996 • 485 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis

2000 • 463 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

1998 • 451 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

1988 • 424 citations

Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

1995 • 414 citations

Host genetic factors influence disease progression in chronic hepatitis C

2000 • 412 citations

Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor

1993 • 401 citations

Innate and adaptive lymphoid cells in the human liver

2000 • 396 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

1999 • 377 citations

In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis

1999 • 325 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1

1998 • 250 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

Inhibition of transforming growth factorβ prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

2000 • 243 citations

Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues.

1993 • 240 citations

Interleukin-6 Inhibits Transforming Growth Factor-β-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt and Signal Transducers and Activators of Transcription 3 Pathways

1999 • 230 citations

Modulation of transforming growth factorβ response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts

2000 • 225 citations

A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C

1997 • 224 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

Transforming growth factor—beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers

1995 • 219 citations

Human Plasminogen Activator Inhibitor-1 (PAI-1) Deficiency: Characterization of a Large Kindred With a Null Mutation in the PAI-1 Gene

1997 • 214 citations

Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis

1997 • 210 citations

Activin induces cell death in hepatocytes in vivo and in vitro

1993 • 206 citations

Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth

1999 • 197 citations

Matricellular Proteins as Modulators of Cell–Matrix Interactions: Adhesive Defect in Thrombospondin 2-null Fibroblasts is a Consequence of Increased Levels of Matrix Metalloproteinase-2

2000 • 193 citations

TGF-β1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis

1999 • 191 citations

Molecular Cloning and Characterization of TIEG2Reveals a New Subfamily of Transforming Growth Factor-β-inducible Sp1-like Zinc Finger-encoding Genes Involved in the Regulation of Cell Growth

1998 • 190 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

γ-interferon treatment inhibits collagen deposition in murine schistosomiasis

1989 • 188 citations

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

2000 • 187 citations

Inhibition of rat hepatic lipocyte activation in culture by interferon-γ

1992 • 185 citations

Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion.

1987 • 184 citations

Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene

1999 • 183 citations

SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-β1 in Mesangial Cells

1999 • 182 citations

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

2000 • 174 citations

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

1999 • 168 citations

Accelerated Wound Healing in Mice With a Disruption of the Thrombospondin 2 Gene

1999 • 166 citations

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation

2000 • 165 citations

In Vitro Migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation

1999 • 164 citations

Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling

2000 • 161 citations

Bone Morphogenetic Protein-9

2000 • 160 citations

Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration

1995 • 157 citations

The transforming growth factor ?1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress

1999 • 157 citations

Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

1990 • 150 citations

Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells

1997 • 144 citations

Hepatic involvement in hereditary hemorrhagic telangiectasia: Clinical, radiological, and hemodynamic studies of 11 cases

1993 • 143 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

Role of Elevated Plasma Transforming Growth Factor-β1 Levels in Wound Healing

1999 • 139 citations

PDGF-Mediated Chemoattraction of Hepatic Stellate Cells by Bile Duct Segments in Cholestatic Liver Injury

2000 • 138 citations

Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas.

1997 • 135 citations

Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma

1999 • 134 citations

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

2000 • 132 citations

Vascular adhesion molecule expression in viral chronic hepatitis: Evidence of neoangiogenesis in portal tracts

1995 • 126 citations

Immunological measurement of transforming growth factor-beta 1 (TGF-beta1) in blood; assay development and comparison.

1997 • 124 citations

Insulinlike growth factor—ii/mannose 6-phosphate receptor is expressed on ccl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells

1995 • 121 citations

Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells

1999 • 120 citations

Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells

2000 • 118 citations

Alternative mechanisms for trafficking of lysosomal enzymes in mannose 6-phosphate receptor-deficient mice are cell type-specific

1999 • 117 citations

Early alcoholic liver injury

1986 • 115 citations

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis

1997 • 112 citations

Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans

1996 • 112 citations

Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1

1998 • 110 citations

Role of transforming growth factor ? type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats

1999 • 107 citations

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

2000 • 105 citations

The Plasminogen–Activating System in Hepatic Stellate Cells

1996 • 100 citations

Activation of caspase-8 in transforming growth factor-?-induced apoptosis of human hepatoma cells

1999 • 99 citations

All-trans-retinoic Acid Increases Transforming Growth Factor-β2 and Insulin-like Growth Factor Binding Protein-3 Expression through a Retinoic Acid Receptor-α-dependent Signaling Pathway

1997 • 94 citations

Induction of Platelet-derived Growth Factor B-chain Expression by Transforming Growth Factor-β Involves Transactivation by Smads

2000 • 94 citations

Autocrine stimulatory mechanism by transforming growth factor beta in human hepatocellular carcinoma.

2000 • 91 citations

Transforming Growth Factor-β Initiates Wound Repair in Rat Liver through Induction of the EIIIA-Fibronectin Splice Isoform

2000 • 89 citations

Loss of Smad3 modulates wound healing

2000 • 86 citations

The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor ?1

1996 • 81 citations

Localization and cellular sources of activins in normal and fibrotic rat liver

1997 • 78 citations

Long- and short-term<scp>d</scp>-α-tocopherol supplementation inhibits liver collagen α1(Ι) gene expression

1998 • 77 citations

Characterization of recombinant soluble human transforming growth factor-β receptor Type II (rhTGF-βsRII)

1995 • 76 citations

Recombinant Latent Transforming Growth Factor β-binding Protein 2 Assembles to Fibroblast Extracellular Matrix and Is Susceptible to Proteolytic Processing and Release

1998 • 74 citations

Transforming Growth Factor-Beta Receptors and Mannose 6-Phosphate/Insulin-Like Growth Factor-II Receptor Expression in Human Hepatocellular Carcinoma

1995 • 74 citations

Dysregulation of Apoptosis in Hepatocellular Carcinoma

1998 • 70 citations

The role of activin and transforming growth factor-β in the regulation of organ mass in the rat liver

2000 • 66 citations

Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia

1998 • 60 citations

Bone Morphogenetic Protein-6 Is Expressed in Nonparenchymal Liver Cells and Upregulated by Transforming Growth Factor-β1

1997 • 59 citations

Mutation Analysis of the Transforming Growth Factor β Type II Receptor in Sporadic Human Cancers of the Pancreas, Liver, and Breast

1996 • 58 citations

Osteonectin (SPARC) expression in human liver and in cultured human liver myofibroblasts.

1997 • 56 citations

Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver

1996 • 55 citations

Expression and matrix deposition of latent transforming growth factor β binding proteins in normal and fibrotic rat liver and transdifferentiating hepatic stellate cells in culture

2001 • 54 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, and Smad4 in hepatocellular carcinoma.

1999 • 54 citations

Focal nodular hyperplasia of the liver: Composition of the extracellular matrix and expression of cell-cell and cell-matrix adhesion molecules

1995 • 53 citations

Mechanisms of Transforming Growth Factor-β Receptor Endocytosis and Intracellular Sorting Differ between Fibroblasts and Epithelial Cells

2001 • 53 citations

Gene mutation of transforming growth factor ?1 type II receptor in hepatocellular carcinoma

1999 • 52 citations

Immunohistochemical evidence of immunopathogenetic mechanisms in chronic hepatitis C recurrence after liver transplantation

1997 • 51 citations

Regulatory mechanisms for transforming growth factorβ as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of Smads in its growth

2000 • 48 citations

Plasminogen activator inhibitor-1 is an immediate early response gene in regenerating rat liver.

1994 • 47 citations

Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium.

1995 • 43 citations

Differential expression of transforming growth factor-β and its receptors in hepatocytes and nonparenchymal cells of rat liver after CCl4 administration

1998 • 41 citations

Clinical Relevance of Transforming Growth Factor-beta 1 in the Urine of Patients with Hepatocellular Carcinoma

1997 • 40 citations

Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells.

1998 • 39 citations

Transforming Growth Factor-β Promotes Epidermal Growth Factor-Induced Thyroid Cell Migration and Follicle Neoformation in Collagen Gel Separable from Cell Proliferation

1995 • 36 citations

Failure to detect genetic alteration of the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene in hepatocellular carcinomas in japan

1999 • 34 citations

Hepatocyte Growth Factor Releases Mink Epithelial Cells from Transforming Growth Factor β1-Induced Growth Arrest by Restoring Cdk6 Expression and Cyclin E-Associated Cdk2 Activity

1999 • 34 citations

Characterization and regulation of the latent transforming growth factor-β complex secreted by vascular pericytes

1996 • 33 citations

FK506 Enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats

1994 • 33 citations

Expression and release of the latent transforming growth factor ? binding protein by hepatocytes from rat liver

1997 • 26 citations

α₂‐Macroglobulin reduces paracrine‐ and autocrine‐stimulated matrix synthesis of cultured rat hepatic stellate cells

1999 • 16 citations

Differential modulation of hepatocyte growth factor-stimulated motility by transforming growth factor β1 on rat liver epithelial cells in vitro

1998 • 15 citations