Latency, activation, and binding proteins of TGF-?

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1999 • 788 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Regulation of Cell Adhesion Receptors by Transforming Growth Factor-β

1989 • 672 citations

Specificity, diversity, and regulation in TGF‐β superfamily signaling

1999 • 644 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Extracellular matrix 4: The elastic fiber

1993 • 598 citations

The molecular and cellular biology of wound repair

1996 • 562 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Tenascin: cDNA cloning and induction by TGF-beta.

1988 • 453 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Solution Structure of a Pair of Calcium-Binding Epidermal Growth Factor-like Domains: Implications for the Marfan Syndrome and Other Genetic Disorders

1996 • 437 citations

Removal of Osteoclast Bone Resorption Products by Transcytosis

1997 • 429 citations

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

1988 • 418 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells

1995 • 398 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.

1987 • 387 citations

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices

1994 • 386 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development

1991 • 350 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

1999 • 336 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

1989 • 333 citations

TGF-β: from latent to active

1999 • 329 citations

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

1996 • 312 citations

Latent transforming growth factor-β binding proteins (LTBPs)—structural extracellular matrix proteins for targeting TGF-β action

1999 • 302 citations

Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β

2000 • 281 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide.

1988 • 273 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Requirement for Activin a and Transforming Growth Factor--β1 Pro-Regions in Homodimer Assembly

1990 • 266 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.

1996 • 236 citations

Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1

1998 • 229 citations

Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.

1996 • 222 citations

Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion

1998 • 209 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin.

1992 • 204 citations

Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.

1994 • 192 citations

Bovine Latent Transforming Growth Factor β1-Binding Protein 2: Molecular Cloning, Identification of Tissue Isoforms, and Immunolocalization to Elastin-Associated Microfibrils

1995 • 186 citations

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

1992 • 181 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

1990 • 162 citations

M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-β1

1999 • 159 citations

Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3)

1995 • 147 citations

Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1

1996 • 143 citations

Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation

1993 • 137 citations

Identification and Characterization of a New Latent Transforming Growth Factor-β-binding Protein, LTBP-4

1998 • 128 citations

The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta.

1991 • 122 citations

Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells

1993 • 118 citations

Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells.

1993 • 112 citations

Latent TGF-β binding protein LTBP-1 contains three potential extracellular matrix interacting domains

2001 • 106 citations

Immunoelectron microscopic localization of transforming growth factor beta 1 and latent transforming growth factor beta 1 binding protein in human gastrointestinal carcinomas: qualitative difference between cancer cells and stromal cells.

1993 • 105 citations

1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells.

1995 • 99 citations

Retention of the transforming growth factor-beta 1 precursor in the Golgi complex in a latent endoglycosidase H-sensitive form.

1992 • 92 citations

[2] Fibrillin: Monomers and microfibrils

1994 • 91 citations

Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor-β Binding Protein with the Extracellular Matrix

1995 • 89 citations

Microfibril-associated Glycoprotein-2 (MAGP-2) Is Specifically Associated with Fibrillin-containing Microfibrils but Exhibits More Restricted Patterns of Tissue Localization and Developmental Expression Than Its Structural Relative MAGP-1

1998 • 89 citations

Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression.

1992 • 85 citations

Sequence and expression of a novel member (LTBP‐4) of the family of latent transforming growth factor‐β binding proteins

1997 • 81 citations

Cell-associated activation of latent transforming growth factor-β by calpain

1998 • 81 citations

Differential regulation of the expression of transforming growth factor‐βs 1 and 2 by retinoic acid, epidermal growth factor, and dexamethasone in NRK‐49F and A549 cells

1991 • 77 citations

Recombinant Latent Transforming Growth Factor β-binding Protein 2 Assembles to Fibroblast Extracellular Matrix and Is Susceptible to Proteolytic Processing and Release

1998 • 74 citations

Acidic cellular environments: Activation of latent tgf‐β and sensitization of cellular responses to tgf‐β and egf

1989 • 69 citations

Lack of the latent transforming growth factor beta binding protein in malignant, but not benign prostatic tissue.

1993 • 61 citations

Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner

1999 • 60 citations

Vitamin D₃and Calcipotriol Enhance the Secretion of Transforming Growth Factor-β1 and -β2 in Cultured Murine Keratinocytes

1993 • 54 citations

Isoforms and splice variant of transforming growth factor β–binding protein in rat hepatic stellate cells

1998 • 52 citations

Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG‐63 human osteosarcoma cells

1995 • 46 citations

Analysis of the expression pattern of the latent transforming growth factor ? binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region

1998 • 42 citations

Loss of a consensus heparin binding site by alternative splicing of latent transforming growth factor‐β binding protein‐1

1998 • 35 citations

Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line

1995 • 33 citations

Enhancement of vitronectin expression in human HepG2 hepatoma cells by transforming growth factor‐β1

1991 • 26 citations

Expression of alternatively spliced human latent transforming growth factor β binding protein‐1

1998 • 26 citations

Vitamin D3 and Calcipotriol Decrease Extracellular Plasminogen Activator Activity in Cultured Keratinocytes

1993 • 22 citations

Role of Latent TGF-β1 Binding Protein in Vascular Remodeling

1998 • 18 citations

Alternative Splicing of LTBP-3

1998 • 14 citations