A Soluble Transforming Growth Factor beta Receptor Expressed in Muscle Prevents Liver Fibrogenesis and Dysfunction in Rats

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1961 • 3,860 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

1998 • 1,102 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDR

1996 • 725 citations

Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney

1996 • 485 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

Assessment of Recombinant Adenoviral Vectors for Hepatic Gene Therapy

1993 • 310 citations

In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.

1994 • 298 citations

Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat

1999 • 296 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts

2001 • 187 citations

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1994 • 154 citations

A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat

1987 • 134 citations

Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-β

2001 • 126 citations

A dimethylnitrosamine-induced model of cirrhosis and portal hypertension in the rat

1985 • 122 citations

Immunohistochemical distribution of type I, II and III collagens in the rabbit supraspinatus tendon insertion.

1994 • 114 citations

Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-β (TGF-β) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-β in Vascular Wall Cells in Primary Culture

1996 • 80 citations

Expression of Smads during in Vitro Transdifferentiation of Hepatic Stellate Cells to Myofibroblasts

2001 • 72 citations

Quantitative Analysis of Repeat Adenovirus-Mediated Gene Transfer Into Injured Canine Femoral Arteries

1995 • 60 citations

Processing of a fusion protein by endoprotease in COS-1 cells for secretion of mature peptide by using a chimeric expression vector.

1993 • 46 citations

Gene therapy and molecular approaches to the treatment of hereditary muscular disorders

2000 • 23 citations

Characterization of a Fusion Protein Composed of the Extracellular Domain of c-kit and the Fc Region of Human IgG Expressed in a Baculovirus System

1993 • 16 citations