Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

1994 • 6,412 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

1999 • 475 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

1999 • 277 citations

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1997 • 275 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

Regulation of Smad signalling by protein associations and signalling crosstalk

1999 • 248 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Rabbit β-Globin Is Extended Beyond Its UGA Stop Codon by Multiple Suppressions and Translational Reading Gaps

1998 • 208 citations

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

1996 • 197 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

Isolation of human cDNA clones ofskiand the ski-related gene,sno

1989 • 169 citations

Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells.

1991 • 158 citations

Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-β superfamily

1995 • 137 citations

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1995 • 131 citations

Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virus

1981 • 90 citations

Serine/threonine kinase receptors

1994 • 89 citations

Sequence and biological activity of chicken snoN cDNA clones.

1993 • 88 citations

Viral Ski Inhibits Retinoblastoma Protein (Rb)-mediated Transcriptional Repression in a Dominant Negative Fashion

1999 • 87 citations

Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product

1990 • 61 citations

Transcriptional Repression by v-Ski and c-Ski Mediated by a Specific DNA Binding Site

1998 • 54 citations

DNA Binding and Transcriptional Activation by the Ski Oncoprotein Mediated by Interaction with NFI

1997 • 48 citations

Activation of a muscle-specific enhancer by the Ski proto-oncogene

1995 • 41 citations