NO in Septic Shock

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Hypoxia of the Renal Medulla — Its Implications for Disease

1995 • 1,191 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Serum Cytokine Levels in Human Septic Shock

1993 • 882 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Diseases of the kidney

1963 • 829 citations

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

1991 • 627 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Nitric oxide synthase in macula densa regulates glomerular capillary pressure.

1992 • 531 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Update in Intensive Care and Emergency Medicine

1989 • 466 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Renal ischemia: A new perspective

1984 • 459 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney

1995 • 368 citations

Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

1993 • 357 citations

The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.

1995 • 355 citations

Expression of Inducible Nitric Oxide in Human Lung Epithelial Cells

1994 • 346 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.

1994 • 323 citations

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.

1996 • 322 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Gram-positive Organisms and Sepsis

1994 • 314 citations

Expression of nitric oxide synthase in kidney macula densa cells

1992 • 296 citations

Early renal medullary hypoxic injury from radiocontrast and indomethacin

1991 • 293 citations

Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys.

1991 • 289 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

Cloning and functional expression of human cDNA for the ETB endothelin receptor

1991 • 273 citations

Multiple Cytokines Are Required to Induce Hepatocyte Nitric Oxide Production and Inhibit Total Protein Synthesis

1990 • 273 citations

Overproduction of Nitric Oxide in Cytokine-Mediated and Septic Shock

1992 • 271 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments.

1992 • 247 citations

Tumor necrosis factor induces glomerular damage in the rabbit.

1989 • 244 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock

1994 • 224 citations

Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide

1989 • 220 citations

Evidence of increased nitric oxide production in patients with the sepsis syndrome.

1993 • 219 citations

The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

1995 • 219 citations

Pathophysiology of Shock, Sepsis, and Organ Failure

1993 • 216 citations

Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.

1994 • 212 citations

L-arginine

1995 • 208 citations

Location of an inducible nitric oxide synthase mRNA in the normal kidney

1994 • 201 citations

Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells

1994 • 195 citations

Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction

1992 • 192 citations

Effects of Hemorrhage on Regional Blood Flow Distribution in Dogs and Primates

1974 • 186 citations

Interleukin-2 Administration Causes Reversible Hemodynamic Changes and Left Ventricular Dysfunction Similar to Those Seen in Septic Shock

1988 • 186 citations

INVITED OPINION

1994 • 185 citations

Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney.

1994 • 185 citations

Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells.

1993 • 184 citations

Randomized, prospective trial of pressure-limited versus volume-controlled ventilation in severe respiratory failure

1994 • 173 citations

Detection of Renal Blood Flow Abnormalities in Septic and Critically III Patients Using a Newly Designed Indwelling Thermodilution Renal Vein Catheter

1990 • 171 citations

Biological actions and pathophysiologic significance of endothelin in the kidney

1991 • 171 citations

Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1.

1989 • 167 citations

Roles for thromboxane A2 and leukotrienes in endotoxin–induced acute renal failure

1986 • 157 citations

Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

1991 • 156 citations

In situ hybridization localization of mRNA encoding inducible nitric oxide synthase in rat kidney

1994 • 149 citations

Localization and regulation of endothelial NO synthase mRNA expression in rat kidney

1994 • 147 citations

An evaluation of the neutrophil as a mediator of in vivo renal ischemic-reperfusion injury.

1989 • 145 citations

Endothelin synthesis by rabbit renal tubule cells

1991 • 145 citations

Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide.

1993 • 143 citations

Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat.

1995 • 139 citations

Renal actions of prostacyclin

1978 • 139 citations

Oxidant injury of cells.

1987 • 135 citations

Heterogeneous regional vascular responses to simulated transient hypovolemia in man

1994 • 135 citations

Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome

1995 • 132 citations

Novel potent and selective inhibitors of inducible nitric oxide synthase.

1995 • 128 citations

Interleukin 1β and tumour necrosis factor α induce a macrophage‐type of nitric oxide synthase in rat renal mesangial cells

1992 • 126 citations

Mild renal ischemia activates primed neutrophils to cause acute renal failure

1992 • 122 citations

Detrimental Hemodynamic Effects of Nitric Oxide Synthase Inhibition in Septic Shock

1994 • 115 citations

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase

1995 • 112 citations

Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells

1994 • 110 citations

Attenuation of endotoxin‐induced multiple organ dysfunction by 1‐amino‐2‐hydroxy‐guanidine, a potent inhibitor of inducible nitric oxide synthase

1996 • 110 citations

An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration

1995 • 108 citations

Effects of nitric oxide synthesis inhibition in hyperdynamic endotoxemia

1994 • 106 citations

Regulated expression of endothelin 1 in glomerular capillary endothelial cells

1991 • 104 citations

Effect of neutrophil depletion on ischemic renal injury in the rat.

1989 • 102 citations

PAF/cytokine auto-generated feedback networks in microvascular immune injury: consequences in shock, ischemia and graft rejection.

1989 • 100 citations

The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat

1991 • 99 citations

Potent selective vasoconstrictor effects of endothelin in the pig kidneyin vivo

1998 • 93 citations

Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages

1996 • 90 citations

Renal function and glomerular hemodynamics in male endotoxemic rats

1989 • 89 citations

Identification of two types of specific endothelin receptors in rat mesangial cell

1989 • 82 citations

Induction of Nitric Oxide Synthase in Human Mesangial Cells

1993 • 81 citations

Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion.

1994 • 80 citations

Dialysate to plasma solute concentration (D/P) versus peritoneal transport parameters in CAPD

1994 • 78 citations

Localization of endothelin-like immunoreactivity in rat kidneys

1991 • 78 citations

Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition

1994 • 77 citations

Inhibition of Interleukin-1- -Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1- -Induced Hypotension by N -Amino-L-arginine

1992 • 76 citations

Human Retinal Pigmented Epithelial Cells Produce Nitric Oxide in Response to Cytokines

1994 • 76 citations

Comparison of the effects of aminoguanidine and Nω-nitro-l-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat

1996 • 74 citations

Neutrophil-mediated post-ischemic tubular leakage in the rat kidney

1989 • 72 citations

The effects of endotoxin on oxygen consumption of various cell types in vitro: An EPR oximetry study

1995 • 70 citations

Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells

1986 • 68 citations

NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS

1993 • 66 citations

Passive immunization against tumour necrosis factor-alpha (TNF-α) and IL-lβ protects from LPS enhancing glomerular injury in nephrotoxic nephritis in rats

1992 • 62 citations

Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats

1995 • 62 citations

Induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells

1992 • 62 citations

Induction of macrophage parasiticidal activity by Staphylococcus aureus and exotoxins through the nitric oxide synthesis pathway.

1993 • 61 citations

Nitric Oxide Synthase Activity is Increased in Patients with Sepsis Syndrome

1995 • 61 citations

The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites

1994 • 59 citations

Endotoxemia, Renal Hypoperfusion, and Fever: Interactive Risk Factors for Aminoglycoside and Sepsis-Associated Acute Renal Failure

1992 • 58 citations

Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats

1994 • 56 citations

Dissociation of systemic and renal effects in endotoxemia. Prostaglandin inhibition uncovers an important role of renal nerves.

1982 • 56 citations

Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line

1995 • 56 citations

The Renal Response to Acute Injury and Sepsis

1976 • 55 citations

Acute renal dysfunction during interleukin-2 treatment: suggestion of an intrinsic renal lesion.

1990 • 55 citations

Antiserum against tumor necrosis factor-alpha and a protease inhibitor reduce immune glomerular injury

1991 • 54 citations

TNF production by the medullary thick ascending limb of Henle's loop

1994 • 54 citations

Nitric oxide synthesis in patients with advanced HIV infection

1994 • 53 citations

Activation of Soluble Guanylyl Cyclase by a Factor Other Than Nitric Oxide or Carbon Monoxide Contributes to the Vascular Hyporeactivity to Vasoconstrictor Agents in the Aorta of Rats Treated with Endotoxin

1994 • 53 citations

Low dose intrarenal infusions of PGE2, PGI2, and 6-keto-PGE1 vasodilate the in vivo rat kidney.

1982 • 53 citations

Role of neutrophil derived oxidants and elastase in lipopolysaccharide-mediated renal injury

1991 • 52 citations

Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2

1989 • 50 citations

Cardiopulmonary responses to continuous administration of endotoxin

1988 • 48 citations

Role of endothelin and tumour necrosis factor in the renal response to sepsis.

1994 • 46 citations

Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform

1995 • 44 citations

Direct effects of endotoxin on the function of the isolated perfused rat kidney

1990 • 44 citations

Cytokine formation within rat glomeruli during experimental endotoxemia.

1993 • 43 citations

Renal oxygenation in endotoxin shock in dogs

1989 • 42 citations

Renal effects of endotoxin in the male rat

1987 • 41 citations

Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells

1993 • 40 citations

Acute Renal Failure in the Intensive Therapy Unit

1990 • 39 citations

Glomerular thrombosis in pregnancy: Role of the L-arginine-nitric oxide pathway

1994 • 39 citations

Response of aequorin-loaded platelets to activators of protein kinase C

1989 • 39 citations

Effects of Nitric Oxide Synthase Inhibition on Regional Blood Flow in a Porcine Model of Endotoxic Shock

1995 • 38 citations

Platelet-activating factor augments tumor necrosis factor and procoagulant activity

1992 • 34 citations

Endothelin increases cyclic GMP levels in LLC-PK1 porcine kidney epithelial cells via formation of an endothelium-derived relaxing factor-like substance.

1991 • 34 citations

Effects of nonsteroidal anti-inflammatory drugs upon intrarenal blood flow: selective medullary hypoperfusion.

1993 • 34 citations

Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells

1995 • 32 citations

Interleukin-2—Induced renal dysfunction in cancer patients is reversed by low-dose dopamine infusion

1995 • 30 citations

Clinical studies on cytokines in sepsis: role of serum cytokines in the development of multiple-systems organ failure.

1994 • 29 citations

Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin‐2

1994 • 29 citations

Effect of lipopolysaccharide on nitric oxide synthase activity in rat proximal tubules

1995 • 28 citations

The Effects of Nitric Oxide Inhibition on Regional Hemodynamics During Hyperdynamic Endotoxemia

1994 • 25 citations

Acute renal failure with preserved renal plasma flow induced by cancer immunotherapy

1991 • 24 citations

The Protective Effect of Thromboxane Synthetase Inhibition on Renal Function in Systemic Sepsis

1989 • 23 citations

Use of nitric oxide synthase inhibitors in animal models of sepsis.

1995 • 23 citations

Renal function and metabolism during endotoxemia in rats: role of hypoperfusion.

1991 • 21 citations

Distribution of intrarenal blood flow during bacterial Sepsis

1978 • 20 citations

Intracellular calcium mediates the cytotoxicity of lipid A in LLC-PK1 cells.

1993 • 19 citations

Nitric Oxide Mediates Redistribution of Intrarenal Blood Flow during Bacteremia

1995 • 17 citations

Kinetics of oxygen in peritoneal cavity. Effects of chemical peritonitis and intraperitoneally administered colloids in rats

1980 • 16 citations

Interstitial Nephritis in a Patient Receiving Adoptive Immunotherapy with Recombinant Interleukin-2 and Lymphokine-Activated Killer Cells

1991 • 15 citations

Acute Renal Failure in the ITU: The Nephrologist’s View

1990 • 10 citations

Pathophysiology of acute renal failure following living Escherichia coli injection in rats: high-energy metabolism and renal functions.

1987 • 10 citations

Nitric Oxide Involvement in Septic Shock: Do Human Beings behave like Rodents?

1996 • 9 citations

RENAL FUNCTION AFTER NITRIC OXIDE INHIBITION IN OVINE BACTERIAL SEPSIS

1994 • 4 citations

Inhibition of Induction or Activity of Nitric Oxide Synthase: Novel Approaches for the Therapy of Circulatory Shock

1995 • 3 citations

Sepsis Related Renal Morphological Alterations and the Functional Correlates

1993 • 3 citations

The Kidney in Sepsis

1993 • 3 citations

Cardiovascular Alterations associated with Interleukin-2 Therapy

1995 • 3 citations

Sepsis and Inflammation: The Process of Dying from Critical Illness

1996 • 2 citations

Role of Nitric Oxide in the Pathogenesis of Gram-positive Shock

1996 • 2 citations

Cellular Actions of Nitric Oxide on the Circulatory System

1995 • 1 citations

Influence of Nitric Oxide on Cardiac Systolic and Diastolic Function

1995 • 1 citations