Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

1990 • 389 citations

Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

1993 • 357 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock

1991 • 188 citations

Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock

1993 • 186 citations

Lipopolysaccharide Induces Hyporesponsiveness to Its Own Action in RAW 264.7 Cells

1989 • 162 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Endotoxin Tolerance Is Associated With Reduced Secretion of Tumor Necrosis Factor

1989 • 127 citations

Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression

1991 • 107 citations

Glucocorticoid‐dependent and ‐independent mechanisms involved in lipopolysaccharide tolerance

1991 • 92 citations

Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.

1993 • 80 citations

Septic shock: treatment

1991 • 77 citations

Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages.

1993 • 71 citations

Pre‐exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity

1993 • 67 citations

Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharide.

1991 • 45 citations

Serum corticosterone, interleukin‐1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains

1993 • 44 citations

Endotoxin tolerance is associated with altered GTP-binding protein function

1992 • 43 citations

In vivo inhibition of lipopolysaccharide-induced lethality and tumor necrosis factor synthesis by Rhodobacter sphaeroides diphosphoryl lipid A is dependent on corticosterone induction

1992 • 40 citations

Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486

1988 • 39 citations

Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats

1993 • 37 citations

Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids.

1992 • 35 citations

Cytotoxic activity and production of toxic nitrogen oxides by macrophages treated with IFN-gamma and monoclonal antibodies against the 73-kDa lipopolysaccharide receptor.

1992 • 30 citations

Tolerance to endotoxin in vitro: independent regulation of interleukin-1, tumor necrosis factor and interferon alpha production during in vitro differentiation of human monocytes.

1990 • 28 citations

Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing N^G‐nitro‐<scp>l</scp>‐arginine

1991 • 13 citations