Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Nitric Oxide: A Physiologic Messenger

1994 • 915 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Nitric oxide modulates microvascular permeability

1992 • 564 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat

1990 • 454 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

1993 • 357 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Nitric oxide and arthritis

1993 • 299 citations

Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

1993 • 289 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

NITRIC OXIDE—A NEW ENDOGENOUS IMMUNOMODULATOR

1993 • 198 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Nitric oxide and cardiovascular control

1993 • 178 citations

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

1991 • 166 citations

Inhibition of nitric oxide formation by guanidines

1993 • 154 citations

Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta

1994 • 143 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery

1986 • 137 citations

Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia.

1993 • 135 citations

Aminoguanidine: A drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitro

1993 • 116 citations

The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation

1994 • 74 citations

Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor

1994 • 72 citations

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis

1992 • 57 citations

Dihydropyridine Antagonists and Agonists of Calcium Channels Inhibit the Induction of Nitric Oxide Synthase by Endotoxin in Cultured Macrophages

1993 • 50 citations

Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat.

1992 • 29 citations