Nitric Oxide Involvement in Septic Shock: Do Human Beings behave like Rodents?

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Measurement of nitric oxide in biological models

1993 • 925 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

The power of words.

1951 • 744 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Expression of Inducible Nitric Oxide in Human Lung Epithelial Cells

1994 • 346 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes

1993 • 334 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin

1992 • 294 citations

Lipopolysaccharide Treatment in Vivo Induces Widespread Tissue Expression of Inducible Nitric Oxide Synthase mRNA

1993 • 265 citations

Methylene blue administration in septic shock

1995 • 263 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

The L-Arginine: Nitric Oxide Pathway Is the Major Source of Plasma Nitrite in Fasted Humans

1995 • 244 citations

Regulation of prostaglandin production by nitric oxide; an in vivo analysis

1995 • 243 citations

Differential Expression of iNOS and cNOS mRNA in Human Vascular Smooth Muscle Cells and Endothelial Cells under Normal and Inflammatory Conditions

1993 • 238 citations

Evidence of increased nitric oxide production in patients with the sepsis syndrome.

1993 • 219 citations

Nitric oxide synthase: MRNA expression of different isoforms in human monocytes/macrophages

1994 • 215 citations

L-arginine

1995 • 208 citations

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

1993 • 204 citations

Pharmacodynamics of Plasma Nitrate/Nitrite as an Indication of Nitric Oxide Formation in Conscious Dogs

1995 • 198 citations

A Rapid and Simple Method for the Measurement of Nitrite and Nitrate in Plasma by High Performance Capillary Electrophoresis

1994 • 198 citations

<scp>l</scp>-Arginine Increases Exhaled Nitric Oxide in Normal Human Subjects

1995 • 154 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats

1997 • 142 citations

Formation of Free Radicals and Nitric Oxide Derivative of Hemoglobin in Rats During Shock Syndrome

1990 • 135 citations

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

1995 • 134 citations

Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man.

1993 • 134 citations

Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome

1995 • 132 citations

Increased Nitric Oxide Production in Patients with Hypotension during Hemodialysis

1995 • 124 citations

Methylene blue increases myocardial function in septic shock

1995 • 121 citations

Increased Nitric Oxide in the Exhaled Air of Patients with Decompensated Liver Cirrhosis

1995 • 113 citations

Methylene blue reverses endotoxin-induced hypotension.

1994 • 110 citations

Cardiac and regional haemodynamics, inducible nitric oxide synthase (NOS) activity, and the effects of NOS inhibitors in conscious, endotoxaemic rats

1995 • 97 citations

Induction of Nitric Oxide Synthase in Human Mesangial Cells

1993 • 81 citations

Nitric Oxide Production Is Increased in Patients after Burn Injury

1996 • 80 citations

Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction

1992 • 77 citations

Human Retinal Pigmented Epithelial Cells Produce Nitric Oxide in Response to Cytokines

1994 • 76 citations

Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin.

1995 • 76 citations

Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway.

1994 • 74 citations

Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.

1994 • 69 citations

NITRIC OXIDE PRODUCTION IS INHIBITED IN TRAUMA PATIENTS

1993 • 66 citations

Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats

1995 • 62 citations

Selective inhibition by dexamethasone of induction of NO synthase, but not of induction of <scp>l</scp>‐arginine transport, in activated murine macrophage J774 cells

1993 • 62 citations

Nitric Oxide Synthase Activity is Increased in Patients with Sepsis Syndrome

1995 • 61 citations

<scp>l</scp>‐Arginine depletion by arginase reduces nitric oxide production in endotoxic shock: an electron paramagnetic resonance study

1995 • 56 citations

Increase in serum NG-hydroxy-l-arginine in rats treated with bacterial lipopolysaccharide

1995 • 54 citations

Nitric oxide synthesis in patients with advanced HIV infection

1994 • 53 citations

Plasma cyclic guanosine 3′–5′ monophosphate concentrations and low vascular resistance in human septic shock

1993 • 43 citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs

1994 • 41 citations

Tetrahydrobiopterin as Another EDRF in Man

1994 • 40 citations

Pharmacokinetic Aspects of Inorganic Nitrate Ingestion in Man

1991 • 36 citations

Influence of endothelium on induction of the L-arginine-nitric oxide pathway in rat aortas

1993 • 33 citations

Inducible L-arginine/nitric oxide pathway in human internal mammary artery and saphenous vein

1995 • 33 citations

Effects of TNF-alpha on hemodynamic changes and circulating endothelium-derived vasoactive factors in dogs

1994 • 20 citations

Is Endotoxin-lnduced Hypotension Related to Nitric Oxide Formation?

1994 • 19 citations

Vascular relaxation and cyclic guanosine monophosphate in a rat model of high output heart failure

1993 • 18 citations

Plasma cyclic guanosine monophosphate in chronic heart failure: Hemodynamic and neurohormonal correlations and response to nitrate therapy

1993 • 14 citations

Hypertension and Decreased Renal Blood Flow Following Methylene Blue Injection

1976 • 13 citations

Effects of NG-substituted arginines on coronary vascular function after endotoxin

1993 • 8 citations