Cardiovascular Alterations associated with Interleukin-2 Therapy

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome

1993 • 1,811 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Profound but Reversible Myocardial Depression in Patients with Septic Shock

1984 • 1,518 citations

Constant-Infusion Recombinant Interleukin-2 in Adoptive Immunotherapy of Advanced Cancer

1987 • 1,224 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients

1989 • 1,003 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

A new technique for measurement of cardiac output by thermodilution in man

1971 • 752 citations

Prospective Randomized Trial of High-Dose Interleukin-2 Alone or in Conjunction With Lymphokine-Activated Killer Cells for the Treatment of Patients With Advanced Cancer

1993 • 639 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Role of nitric oxide in gastrointestinal and hepatic function and disease

1992 • 493 citations

Endothelial Cell Production of Nitrogen Oxides in Response to Interferon in Combination With Tumor Necrosis Factor, Interleukin-1, or Endotoxin

1990 • 474 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

High-Dose Recombinant Interleukin 2 in the Treatment of Patients With Disseminated Cancer

1986 • 459 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis^1,²

1986 • 367 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Shock and Multiple-Organ Dysfunction after Self-Administration of Salmonella Endotoxin

1993 • 265 citations

Cardiorespiratory effects of immunotherapy with interleukin-2.

1989 • 246 citations

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

1990 • 230 citations

Interleukin 2-activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelial cells and cause their lysis.

1987 • 219 citations

Induction of circulating tumor necrosis factor (TNFα) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients

1988 • 210 citations

Circulating cytokines in patients with metastatic cancer treated with recombinant interleukin 2 and lymphokine-activated killer cells.

1988 • 197 citations

Studies of interferon as a regulator of hematopoietic cell proliferation.

1985 • 195 citations

The Development of New Immunotherapies for the Treatment of Cancer Using Interleukin-2

1988 • 181 citations

Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients

1987 • 166 citations

Effects of NG-Methyl-L-arginine, NG-Nitro-L-arginine, and Aminoguanidine on Constitutive and Inducible Nitric Oxide Synthase in Rat Aorta

1994 • 143 citations

Circulating Factors in the Etiology of Pulmonary Insufficiency and Right Heart Failure Accompanying Severe Sepsis (Peritonitis)

1970 • 120 citations

Effect of Endogenous Nitric Oxide on Mitochondrial Respiration of Rat Hepatocytes In Vitro and In Vivo

1991 • 114 citations

Inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects [see comments]

1990 • 109 citations

Cardiovascular performance with E. coli challenges in a canine model of human sepsis

1988 • 83 citations

Laboratory correlates of adoptive immunotherapy with recombinant interleukin-2 and lymphokine-activated killer cells in humans.

1988 • 80 citations

Tumor targets stimulate IL-2 activated killer cells to produce interferon-gamma and tumor necrosis factor.

1989 • 79 citations

Nitric oxide hemoglobin in mice and rats in endotoxic shock

1991 • 76 citations

Inhibition of Interleukin-1- -Induced Nitric Oxide Synthase in Vascular Smooth Muscle and Full Reversal of Interleukin-1- -Induced Hypotension by N -Amino-L-arginine

1992 • 76 citations

Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment.

1990 • 75 citations

High-Dose Recombinant Interleukin-2 Alone: A Regimen With Limited Activity in the Treatment of Advanced Renal Cell Carcinoma

1990 • 71 citations

Antiplatelet effects of endothelium-derived relaxing factor and nitric oxide donors

1991 • 65 citations

Interleukin‐2 induces activation of coagulation and fibrinolysis: resemblance to the changes seen during experimental endotoxaemia

1992 • 60 citations

Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C

1992 • 60 citations

Infectious complications associated with interleukin-2 administration: a retrospective review of 935 treatment courses.

1993 • 52 citations

Fibrinolysis in Critically III Patients

1989 • 52 citations

Pentoxifylline inhibits interleukin-2-induced toxicity in C57BL/6 mice but preserves antitumor efficacy.

1992 • 42 citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs

1994 • 41 citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs

1994 • 40 citations

Platelet activating factor mediates interleukin-2-induced lung injury in the rat.

1992 • 29 citations

Central Nervous System Toxicity of Biological Response Modifiers

1990 • 19 citations

Lessons from the clinical trials of interleukin-2.

1990 • 15 citations

A comparison of the cardiopulmonary effects of continuous versus bolus infusion of recombinant interleukin-2 in sheep.

1988 • 14 citations

Blood coagulation abnormalities during adoptive immunotherapy with interleukin-2 (r-Met Hu IL-2 [ala 125])

1991 • 11 citations

Inotropic and vasoactive drug treatment of interleukin 2 induced hypotension in sheep.

1989 • 10 citations

Treatment with pentoxifylline and ciprofloxacin reduces the toxicity of high-dose interleukin-2 and lymphokine-activated killer cells.

1993 • 10 citations

Endothelium-derived Relaxing Factor Inhibits Shear Stress-induced Platelet Aggregation

1993 • 5 citations

Book Review Courage under Siege: Starvation, Disease, and Death in the Warsaw Ghetto By Charles G. Roland. 352 pp., illustrated. New York, Oxford University Press, 1992. $25. 0-19-506285-X

1993 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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