Response of aequorin-loaded platelets to activators of protein kinase C

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca²⁺ flux in human platelets

1985 • 173 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester

1984 • 109 citations

Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

1986 • 101 citations

Phorbol ester contracts rabbit thoracic aorta by increasing intracellular calcium and by activating calcium influx

1986 • 91 citations

Synergism of platelet-aggregating agents. Role of elevation of cytoplasmic calcium.

1987 • 79 citations

Aequorin detects increased cytoplasmic calcium in platelets stimulated with phorbol ester or diacylglycerol

1985 • 64 citations

Inhibition of human platelet aggregation and cytoplasmic calcium response by calcium antagonists: studies with aequorin and quin2.

1986 • 54 citations

Diacylglycerol increases cytosolic free Ca2+ concentration in rat pituitary cells. Relationship to thyrotropin-releasing hormone action.

1987 • 54 citations

Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and β-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate

1986 • 40 citations

Concurrent measurement of platelet ionized calcium concentration and aggregation: Studies with the Lumiaggregometer

1985 • 38 citations

Diacylglycerol causes Ca release from the platelet dense tubular system: comparisons with Ca release caused by inositol 1,4,5-triphosphate

1987 • 31 citations

Calcium transients in human platelets monitored by aequorin, fura-2 and quin-2: Effects of protein kinase C activation and inhibition

1987 • 24 citations

Rapid effects ofphorbol ester on platelet shape change, cytoskeleton and calcium transient

1986 • 22 citations

Effect of phorbol esters and diacylglycerols on calcium transport by human platelet membranes

1986 • 10 citations