Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Nitric Oxide: A Physiologic Messenger

1994 • 915 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Organic chemistry of bivalent sulfur

1958 • 496 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Characterization of the novel nitric oxide synthase inhibitor 7‐nitro indazole and related indazoles: antinociceptive and cardiovascular effects

1993 • 470 citations

Amelioration of chronic ileitis by nitric oxide synthase inhibition.

1993 • 416 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1993 • 402 citations

Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages

1991 • 391 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

1993 • 357 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Nitric oxide and arthritis

1993 • 299 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock

1994 • 224 citations

Location of an inducible nitric oxide synthase mRNA in the normal kidney

1994 • 201 citations

NITRIC OXIDE—A NEW ENDOGENOUS IMMUNOMODULATOR

1993 • 198 citations

INVITED OPINION

1994 • 185 citations

Nitric oxide and cardiovascular control

1993 • 178 citations

Thioureas

1955 • 172 citations

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

1991 • 166 citations

Effects of guanidino and uremic compounds on nitric oxide pathways

1994 • 161 citations

The Role of Nitric Oxide in Endotoxic Shock: Effects of NG-Monomethyl-L-Arginine

1992 • 157 citations

Inhibition of nitric oxide formation by guanidines

1993 • 154 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery

1986 • 137 citations

Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia.

1993 • 135 citations

The Croonian Lecture, 1993. The endothelium: maestro of the blood circulation

1994 • 74 citations

Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor

1994 • 72 citations

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis

1992 • 57 citations

Dihydropyridine Antagonists and Agonists of Calcium Channels Inhibit the Induction of Nitric Oxide Synthase by Endotoxin in Cultured Macrophages

1993 • 50 citations

HEPATIC INTERCELLULAR COMMUNICATION IN SHOCK AND INFLAMMATION

1994 • 50 citations

Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat.

1992 • 29 citations

THE ACTION OF THE HALOGEN HYDRINS AND OF ETHYLENE OXIDE ON THE THIOUREAS

1930 • 13 citations