New insights into the regulation of inducible nitric oxide synthesis

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

1993 • 825 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress

1994 • 534 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

1990 • 456 citations

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

1993 • 411 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

The surprising life of NITRIC OXIDE

1993 • 316 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.

1993 • 266 citations

Lipopolysaccharide Treatment in Vivo Induces Widespread Tissue Expression of Inducible Nitric Oxide Synthase mRNA

1993 • 265 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Regulation of Enzymes of Urea and Arginine Synthesis

1992 • 252 citations

<scp>l</scp>-arginine transport is increased in macrophages generating nitric oxide

1992 • 235 citations

Macrophages can convert citrulline into arginine

1992 • 217 citations

Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.

1994 • 216 citations

Arginine metabolism in wounds

1988 • 196 citations

Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines.

1993 • 188 citations

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes

1990 • 179 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Characterization of the third member of the MCAT family of cationic amino acid transporters. Identification of a domain that determines the transport properties of the MCAT proteins.

1993 • 145 citations

Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages

1993 • 111 citations

Nitric oxide production by cultured aortic endothelial cells in response to thiol depletion and replenishment.

1991 • 110 citations

Microenvironmental arginine depletion by macrophages in vivo

1979 • 99 citations

Heme coordination and structure of the catalytic site in nitric oxide synthase.

1993 • 99 citations

Inhibition of inducible nitric oxide synthase in macrophages by oxidized low-density lipoproteins.

1994 • 88 citations

Transforming Growth Factor β Differentially Modulates the Inducible Nitric Oxide Synthase Gene in Distinct Cell Types

1993 • 79 citations

The Human Argininosuccinate Synthetase Locus and Citrullinemia

1986 • 71 citations

Arginine Transport in Human Liver

1993 • 68 citations

Selective inhibition by dexamethasone of induction of NO synthase, but not of induction of <scp>l</scp>‐arginine transport, in activated murine macrophage J774 cells

1993 • 62 citations

Effect of lipopolysaccharide on transport and metabolism of arginine in mouse peritoneal macrophages

1992 • 58 citations

Inhibition of cytokine‐induced nitric oxide production by transforming growth factor‐beta 1 in human smooth muscle cells.

1992 • 54 citations

Amino acid uptake in isolated, perfused liver: Effect of trauma and sepsis

1988 • 31 citations

Endotoxin stimulates arginine transport in pulmonary artery endothelial cells.

1993 • 30 citations

Parallel Induction of Nitric Oxide and Glucose-6-Phosphate Dehydrogenase in Activated Bone Marrow Derived Macrophages

1993 • 28 citations

The activation of the arginine-citrulline cycle in macrophages from the spontaneously diabetic BB rat

1993 • 28 citations

Stimulation by D-glucose of the direct conversion of arginine to citrulline in enterocytes isolated from pig jejunum

1991 • 24 citations