The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

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1992 • 2,725 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

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Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure.

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An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury

1992 • 274 citations

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

1995 • 274 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells

1993 • 248 citations

Nitric oxide and nitric oxide‐generating compounds inhibit hepatocyte protein synthesis

1991 • 227 citations

The Role of the l-arginine: Nitric Oxide Pathway in Circulatory Shock

1994 • 224 citations

Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock

1993 • 186 citations

Endogenous Peroxynitrite Is Involved in the Inhibition of Mitochondrial Respiration in Immuno-Stimulated J774.2 Macrophages

1995 • 109 citations

Nitric oxide and prostaglandins interact to prevent hepatic damage during murine endotoxemia

1994 • 75 citations

Comparison of the effects of aminoguanidine and Nω-nitro-l-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat

1996 • 74 citations

The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria.

1995 • 45 citations