Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide.

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

Widespread tissue distribution, species distribution and changes in activity of Ca²⁺‐dependent and Ca²⁺‐independent nitric oxide synthases

1991 • 645 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Mediators produced by the endothelial cell.

1988 • 329 citations

Incubation with endotoxin activates the L-arginine pathway in vascular tissue

1990 • 193 citations

Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin

1990 • 186 citations

Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage

1991 • 167 citations

Effect of Hemorrhagic Shock on the Reactivity of Resistance and Capacitance Vessels and on Capillary Filtration Transfer in Cat Skeletal Muscle

1963 • 125 citations

Characterization of nitric oxide synthases in non‐adrenergic non‐cholinergic nerve containing tissue from the rat anococcygeus muscle

1991 • 107 citations

Plasma Concentration of Epinephrine and Norepinephrine in Hemorrhagic and Anaphylactic Shock

1957 • 69 citations

An improved chromogenic substrate endotoxin assay for clinical use.

1983 • 53 citations

Cutaneous and skeletal muscle vascular responses to hemorrhage and irreversible shock

1967 • 49 citations

Vascular adrenergic interactions during hemorrhagic shock.

1985 • 42 citations

Coronary and Peripheral Blood Flow in Experimental Hemorrhagic Hypotension Treated with L-Nor-Epinephrine

1955 • 29 citations

Plasma concentrations of endotoxin following jugular or portal injections of endotoxin and following gastrointestinal ischemia due to hemorrhage.

1991 • 21 citations

Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing N^G‐nitro‐<scp>l</scp>‐arginine

1991 • 13 citations

Endothelium-dependent responses and their potential relevance to the distribution of blood flow during hemorrhagic shock

1989 • 9 citations

Blood pressure responses associated with hemorrhagic shock in anesthetized rats.

1982 • 7 citations

Effect of hemorrhagic shock on release of norepinephrine by tyramine

1964 • 6 citations

Response of the Vascular System to Sympathetic Stimuli during Shock

1953 • 3 citations