Apoptosis in sepsis: a new target for therapeutic exploration

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference

1992 • 4,689 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

1999 • 1,307 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

Septic Shock in Humans

1990 • 1,170 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome

1993 • 1,068 citations

Two TNF receptors

1992 • 1,048 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Sir Isaac Newton, sepsis, SIRS, and CARS

1996 • 993 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

The molecular biology of apoptosis.

1996 • 963 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?

1998 • 705 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Major Injury Leads to Predominance of the T Helper-2 Lymphocyte Phenotype and Diminished Interleukin-12 Production Associated with Decreased Resistance to Infection

1995 • 503 citations

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

1995 • 493 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

1998 • 463 citations

Prevention of lymphocyte cell death in sepsis improves survival in mice

1999 • 444 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Neutrophil Apoptosis in the Acute Respiratory Distress Syndrome

1997 • 394 citations

Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS)

1999 • 358 citations

Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma

1997 • 357 citations

Overexpression of Bcl-2 in Transgenic Mice Decreases Apoptosis and Improves Survival in Sepsis

1999 • 354 citations

The molecular pathogenesis of endotoxic shock and organ failure

1999 • 344 citations

Dysregulated Expression of Neutrophil Apoptosis in the Systemic Inflammatory Response Syndrome

1997 • 336 citations

Apoptosis in lymphoid and parenchymal cells during sepsis

1997 • 335 citations

Bcl-2 family proteins as ion-channels

1998 • 299 citations

Glucocorticoids inhibit apoptosis of human neutrophils

1995 • 294 citations

Interleukin-10 Counterregulates Proinflammatory Cytokine-Induced Inhibition of Neutrophil Apoptosis During Severe Sepsis

1997 • 294 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators

1996 • 254 citations

Activation of Caspase 3 (CPP32)-Like Proteases Is Essential for TNF-α-Induced Hepatic Parenchymal Cell Apoptosis and Neutrophil-Mediated Necrosis in a Murine Endotoxin Shock Model

1998 • 253 citations

Sepsis-induced apoptosis of the thymocytes in mice.

1994 • 237 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Listeria monocytogenes induces apoptosis of infected hepatocytes.

1996 • 213 citations

CECAL LIGATION AND PUNCTURE (CLP) INDUCES APOPTOSIS IN THYMUS, SPLEEN, LUNG, AND GUT BY AN ENDOTOXIN AND TNF-INDEPENDENT PATHWAY

1997 • 207 citations

The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction

1994 • 207 citations

Neutrophil migration during endotoxemia

1999 • 197 citations

Death receptors in liver biology and pathobiology

1999 • 192 citations

BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins

2000 • 185 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

1995 • 178 citations

LPS Challenge in D-galactosamine–Sensitized Mice Accounts for Caspase-dependent Fulminant Hepatitis, not for Septic Shock

1999 • 178 citations

Soluble Fas Ligand Is Chemotactic for Human Neutrophilic Polymorphonuclear Leukocytes

1999 • 175 citations

Interleukin-6 Delays Neutrophil Apoptosis

1996 • 159 citations

Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis

1997 • 158 citations

T-cell reactivity and its predictive role in immunosuppression after burns

1999 • 151 citations

IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils

1996 • 147 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

Search for Sepsis Drugs Goes on Despite Past Failures

1994 • 135 citations

THE INDUCTION OF ACCELERATED THYMIC PROGRAMMED CELL DEATH DURING POLYMICROBIAL SEPSIS

1995 • 135 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

DNA fragmentation in mouse organs during endotoxic shock.

1996 • 133 citations

SEQUESTRATION OF NEUTROPHILS IN THE HEPATIC VASCULATURE DURING ENDOTOXEMIA IS INDEPENDENT OF β2 INTEGRINS AND INTERCELLULAR ADHESION MOLECULE-1

1996 • 131 citations

Release of Anti-inflammatory Mediators after Mechanical Trauma Correlates with Severity of Injury and Clinical Outcome

1995 • 123 citations

Mechanisms of Lung Neutrophil Activation After Hemorrhage or Endotoxemia: Roles of Reactive Oxygen Intermediates, NF-κB, and Cyclic AMP Response Element Binding Protein

1999 • 119 citations

LYMPHOCYTE SUBSET RESPONSES TO TRAUMA AND SEPSIS

1993 • 118 citations

Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice

1999 • 106 citations

Is Fas Ligand or Endotoxin Responsible for Mucosal Lymphocyte Apoptosis in Sepsis?

1998 • 89 citations

Glucocorticoid-induced, caspase-dependent organ apoptosis early after burn injury

2000 • 77 citations

Lymphocytopenia in a hospital population ‐ what does it signify?

1997 • 76 citations

Increased inducible apoptosis in CD4⁺ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin

1999 • 72 citations

Altered Gene Transcription After Burn Injury Results in Depressed T-Lymphocyte Activation

1994 • 70 citations

CIRCULATING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IN PLASMA OF PATIENTS WITH THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME DELAYS NEUTROPHIL APOPTOSIS THROUGH INHIBITION OF SPONTANEOUS REACTIVE OXYGEN SPECIES GENERATION

1999 • 69 citations

Caspase-3–Dependent Organ Apoptosis Early After Burn Injury

1999 • 67 citations

Immune deficiency following thermal trauma is associated with apoptotic cell death

1995 • 67 citations

Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells

1999 • 62 citations

Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury

1997 • 59 citations

Role of tumor necrosis factor-α and glucocorticoid on lipopolysaccharide (LPS)-induced apoptosis of thymocytes

1995 • 51 citations

Inhibition of Neutrophil Apoptosis after Severe Trauma Is NF???? Dependent

2000 • 45 citations

DOES FAS LIGAND OR ENDOTOXIN CONTRIBUTE TO THYMIC APOPTOSIS DURING POLYMICROBIAL SEPSIS?

1999 • 44 citations

Discordant tumor necrosis factor-α superfamily gene expression in bacterial peritonitis and endotoxemic shock

1999 • 27 citations