Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice
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References (69)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
1970 • 253,849 citations
Cell Death: The Significance of Apoptosis
1980 • 7,281 citations
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 • 7,177 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 • 5,133 citations
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 • 4,921 citations
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 • 4,728 citations
Manipulating the mouse embryo: A laboratory manual
1986 • 4,548 citations
Programmed Cell Death in Animal Development
1997 • 2,690 citations
Social controls on cell survival and cell death
1992 • 2,641 citations
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1996 • 2,304 citations
Caspases: Intracellular Signaling by Proteolysis
1997 • 2,114 citations
Mechanisms and Functions of Cell Death
1991 • 2,061 citations
Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
1990 • 1,793 citations
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types
1974 • 1,697 citations
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
1993 • 1,638 citations
Bax directly induces release of cytochrome c from isolated mitochondria
1998 • 1,514 citations
Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
1994 • 1,106 citations
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
1998 • 899 citations
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
1998 • 872 citations
Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis
1994 • 820 citations
Programmed cell death and Bcl-2 protection in very low oxygen
1995 • 638 citations
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine II. Mucous cells
1974 • 618 citations
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL
1995 • 611 citations
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine I. Columnar cell
1974 • 565 citations
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.
1994 • 564 citations
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997 • 555 citations
Nuclear changes in apoptosis
1995 • 538 citations
Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice
1993 • 402 citations
Role for Bcl-xLas an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
1997 • 397 citations
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.
1994 • 396 citations
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
1997 • 388 citations
Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.
1997 • 375 citations
Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.
1996 • 360 citations
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine III. Entero‐endocrine cells
1974 • 310 citations
Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia
1995 • 308 citations
Evidence of a Novel Event during Neuronal Death
1998 • 276 citations
A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine
1990 • 268 citations
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.
1994 • 264 citations
A clonal marker induced by mutation in mouse intestinal epithelium
1988 • 255 citations
The stem‐cell zone of the small intestinal epithelium. I. Evidence from paneth cells in the adult mouse
1981 • 253 citations
Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol
1998 • 236 citations
bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.
1995 • 227 citations
Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system.
1996 • 221 citations
Human IAP-Like Protein Regulates Programmed Cell Death Downstream of Bcl-xL and Cytochrome c
1998 • 216 citations
Programmed cell death induced by ischemia-reperfusion in rat intestinal mucosa
1998 • 208 citations
Apoptosis Repressor Genes Bcl-2 and Bcl-x-Long are Expressed in the Rat Brain following Global Ischemia
1997 • 203 citations
Characterization of Radiation-induced Apoptosis in the Small Intestine and Its Biological Implications
1994 • 202 citations
The stem‐cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse
1981 • 193 citations
Role of BCL-2 in the survival and function of developing and mature sympathetic neurons
1995 • 193 citations
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine IV. Paneth cells
1974 • 169 citations
Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells
1998 • 160 citations
Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages
1994 • 153 citations
Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells
1998 • 119 citations
Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.
1993 • 104 citations
Activation of a PP2A-like phosphatase and dephosphorylation of τ protein characterize onset of the execution phase of apoptosis
1998 • 98 citations
The use of antibodies to 5-bromo-2'-deoxyuridine for the isolation of DNA sequences containing excision-repair sites.
1984 • 85 citations
Clonality and Life Cycles of Intestinal Crypts Explained by a State Dependent Stochastic Model of Epithelial Stem Cell Organization
1997 • 85 citations
Apoptosis After Intestinal Ischemia-Reperfusion Injury
1997 • 85 citations
Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis
1997 • 80 citations
Expression of p21(WAF1/CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury.
1996 • 55 citations
Whole population cell kinetics of mouse duodenal, jejunal, iieal, and colonic epithelia as determined by radioautography and flow cytometry
1982 • 53 citations
Use of transgenic mice to study the routing of secretory proteins in intestinal epithelial cells: analysis of human growth hormone compartmentalization as a function of cell type and differentiation.
1989 • 51 citations
Regulation of Bcl-xl Channel Activity by Calcium
1998 • 50 citations
Suppressor and Activator Functions Mediated by a Repeated Heptad Sequence in the Liver Fatty Acid-binding Protein Gene (Fabpl)
1997 • 40 citations
Cell production in mouse intestinal epithelium measured by stathmokinetic flow cytometry and coulter particle counting
1983 • 33 citations
γ-Ray-induced apoptosis in transgenic mice with proliferative abnormalities in their intestinal epithelium: re-entry of villus enterocytes into the cell cycle does not affect their radioresistance but enhances the radiosensitivity of the crypt by inducing p53
1997 • 31 citations
CALCIUM BLOCKADE REDUCES RENAL APOPTOSIS DURING ISCHEMIA REPERFUSION
1997 • 28 citations
Bi-transgenic Mice Reveal that K-rasVal12 Augments a p53-independent Apoptosis When Small Intestinal Villus Enterocytes Reenter the Cell Cycle
1997 • 21 citations
Dying enterocytes downregulate signaling pathways converging on Ras: rescue by protease inhibition
1998 • 17 citations