Is Fas Ligand or Endotoxin Responsible for Mucosal Lymphocyte Apoptosis in Sepsis?

Social controls on cell survival and cell death

1992 • 2,641 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

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1988 • 795 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

Endotoxemia in Human Septic Shock

1991 • 656 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.

1983 • 507 citations

The Role of Intestinal Barrier Failure and Bacterial Translocation in the Development of Systemic Infection and Multiple Organ Failure

1990 • 484 citations

Apoptosis in lymphoid and parenchymal cells during sepsis

1997 • 335 citations

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

1993 • 314 citations

Regulation of IgA synthesis and immune response by T cells and interleukins

1989 • 278 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators

1996 • 254 citations

Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria.

1982 • 223 citations

Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.

1981 • 222 citations

Pathophysiology of Shock, Sepsis, and Organ Failure

1993 • 216 citations

CECAL LIGATION AND PUNCTURE (CLP) INDUCES APOPTOSIS IN THYMUS, SPLEEN, LUNG, AND GUT BY AN ENDOTOXIN AND TNF-INDEPENDENT PATHWAY

1997 • 207 citations

Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells

1992 • 195 citations

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

1991 • 175 citations

Regulation of apoptosis in neutrophils--Fas track to death?

1995 • 127 citations

Fas-Mediated Apoptosis

1996 • 118 citations

Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.

1993 • 117 citations

In vivo induction of apoptosis (programmed cell death) in mouse thymus by administration of lipopolysaccharide

1993 • 102 citations

Increased Mucosal B-Lymphocyte Apoptosis During Polymicrobial Sepsis Is a Fas Ligand But Not an Endotoxin-Mediated Process

1998 • 90 citations

Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukins-1 and -6 and tumor necrosis factor).

1992 • 88 citations

Role of Interleukin 6 and Transforming Growth Factor–β in the Induction of Depressed Splenocyte Responses Following Sepsis

1993 • 81 citations

Differential alterations in microvascular perfusion in various organs during early and late sepsis

1992 • 63 citations

Factors Responsible for Peritoneal Granulocyte Apoptosis during Sepsis

1997 • 45 citations

Sepsis Induces Increased Apoptosis in Lamina Propria Mononuclear Cells Which Is Associated with Altered Cytokine Gene Expression

1998 • 35 citations

Phenotypic and immunoregulatory analysis of intestinal T‐cells in patients with inflammatory bowel disease: evaluation of an in vitro model

1995 • 24 citations

Sepsis and Multiple Organ Failure: The Result of Whole Body Inflammation

1993 • 19 citations

Multiple organ failure syndrome

1994 • 18 citations

Immunological Abnormality in C3H/HeJ Mice with Heritable Inflammatory Bowel Disease

1996 • 10 citations

Immunologic Dyshomeostasis in Multiple Organ Failure: The Gut-Liver Axis

1993 • 9 citations