BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

1974 • 1,697 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

1985 • 1,021 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.

1988 • 499 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Cancer Statistics, 1989

1989 • 315 citations

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.

1987 • 297 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

A Correlative Morphologic Study of Human Breast and Endometrium in the Menstrual Cycle

1986 • 285 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

1990 • 223 citations

Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma

1987 • 200 citations

Prolonged antigen half-life in the lymphoid follicles of specifically immunized mice.

1979 • 186 citations

Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis.

1983 • 147 citations

Ultrastructure of cell loss in intestinal mucosa

1977 • 116 citations

Direct toxic effect of Lodide in excess on Lodine-deficient thyroid glands: Epithelial necrosis and inflammation associated with lipofuscin accumulation

1986 • 95 citations

Ultrastructural observations on cell death by apoptosis in the ?resting? human breast

1981 • 83 citations

Pathologic Basis of Disease

1981 • 82 citations

Nesidioblastosis and endocrine hyperplasia of the pancreas: A secondary phenomenon

1986 • 68 citations

The bcl-2 Candidate Proto-Oncogene Product Is a 24-Kilodalton Integral-Membrane Protein Highly Expressed in Lymphoid Cell Lines and lymphomas Carrying the t(14;18) Translocation

1989 • 61 citations

Deregulated Bcl-2-Immunoglobulin Transgene Expands a Resting but Responsive Immunoglobulin M and D-Expressing B-Cell Population

1990 • 54 citations

Ultraviolet‐Induced Individual Cell Keratinization

1974 • 45 citations

The ultrastructure of the human epidermis in chronic graft-versus-host disease.

1979 • 42 citations

The ultrastructure of the human epidermis in chronic graft-versus-host disease.

1979 • 9 citations