Interleukin-10 Counterregulates Proinflammatory Cytokine-Induced Inhibition of Neutrophil Apoptosis During Severe Sepsis

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

The production of cytokines by polymorphonuclear neutrophils

1995 • 918 citations

Serum Cytokine Levels in Human Septic Shock

1993 • 882 citations

Neutrophils in Human Diseases

1987 • 852 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Sepsis syndrome

1989 • 523 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Poly's lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response

1992 • 459 citations

High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines

1991 • 446 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 367 citations

Interleukin-10 production during septicaemia

1994 • 365 citations

Interleukin-8 in sepsis: relation to shock and inflammatory mediators

1992 • 313 citations

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.

1996 • 238 citations

Granulocyte apoptosis and the control of inflammation

1994 • 232 citations

Relationship of Interleukin-10 Plasma Levels to Severity of Injury and Clinical Outcome in Injured Patients

1997 • 219 citations

Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

1994 • 205 citations

Bronchial Epithelial Cell-derived Cytokines (G-CSF and GM-CSF Promote the Survical of Peripheral Blood Neutrophils In Vitro

1992 • 193 citations

Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α

1993 • 149 citations

IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils

1996 • 147 citations

Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway.

1994 • 136 citations

Interleukin‐2 prevention of apoptosis in human neutrophils

1994 • 117 citations

In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-alpha or cycloheximide.

1995 • 105 citations

Changes in Granulocyte Colony-Stimulating Factor Concentration in Patients with Trauma and Sepsis

1996 • 86 citations

Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon- gamma

1996 • 84 citations

Recombinant granulocyte colony-stimulating factor and lipopolysaccharide maintain the phenotype of and superoxide anion generation by neutrophils

1990 • 38 citations

Differential alterations in plasma colony-stimulating factor concentrations in meningococcaemia

1995 • 33 citations