The Tumor Necrosis Factor Ligand and Receptor Families

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Coronary Plaque Disruption

1995 • 3,542 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

1986 • 1,323 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.

1989 • 1,233 citations

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

1989 • 1,199 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1992 • 960 citations

Matrix Metalloproteinases and Cardiovascular Disease

1995 • 873 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.

1992 • 828 citations

Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.

1995 • 810 citations

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

1994 • 792 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.

1991 • 591 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

The Unstable Atheroma

1997 • 568 citations

Roles of Infectious Agents in Atherosclerosis and Restenosis

1997 • 566 citations

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

1987 • 545 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response

1990 • 483 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

1996 • 454 citations

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

1996 • 435 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

1990 • 364 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1994 • 343 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

The other side of scavenger receptors: pattern recognition for host defense

1997 • 312 citations

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

1984 • 302 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor.

1993 • 297 citations

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

1984 • 284 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

1987 • 279 citations

Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.

1993 • 276 citations

Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells.

1982 • 272 citations

Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells

1997 • 270 citations

Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor

1995 • 265 citations

Through thick and thin: Wasting, obesity, and TNFα

1993 • 223 citations

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

1994 • 220 citations

Lipoprotein Trafficking in Vascular Cells

1997 • 178 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group

1995 • 153 citations

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.

1990 • 133 citations

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

1990 • 133 citations

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance

1994 • 116 citations

A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its ‘death domain’

1995 • 61 citations

Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration.

1995 • 53 citations

An Evolutionary and Functional Approach to the TNF Receptor/Ligand Family

1994 • 45 citations

Tumor necrosis factor and the therapeutic potential of anti-tumor necrosis factor antibodies

1993 • 39 citations

Chimeric tumor necrosis factor receptors with constitutive signaling activity.

1995 • 38 citations

Serum amyloid A protein family. Differential induction by oxidized lipids in mouse strains.

1994 • 34 citations

Characterization of a primate model of asthma using anti-allergy/ anti-asthma agents

1996 • 29 citations

Model for cachexia in chronic disease: secretory products of endotoxin-stimulated macrophages induce a catabolic state in 3T3-L1 adipocytes.

1984 • 29 citations

The development of American physiology

1987 • 21 citations