Obesity and Cancer Mechanisms: Cancer Metabolism

The Hallmarks of Cancer

2000 • 27,569 citations

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

2009 • 13,873 citations

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

2014 • 7,830 citations

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

2012 • 5,369 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Cancer Cell Metabolism: Warburg and Beyond

2008 • 2,255 citations

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

2013 • 2,226 citations

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

2011 • 1,906 citations

Estrogen Carcinogenesis in Breast Cancer

2006 • 1,780 citations

The insulin signaling system.

1994 • 1,733 citations

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

2011 • 1,608 citations

Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies

2012 • 1,527 citations

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

2014 • 1,515 citations

Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study

2007 • 1,422 citations

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

2008 • 1,108 citations

The insulin and insulin-like growth factor receptor family in neoplasia: an update

2012 • 1,034 citations

Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.

2002 • 1,002 citations

New Users of Metformin Are at Low Risk of Incident Cancer

2009 • 974 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Exercise for overweight or obesity

2006 • 941 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets

2013 • 764 citations

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

2003 • 740 citations

Adipose tissue and adipocytes support tumorigenesis and metastasis

2013 • 681 citations

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

2011 • 670 citations

Causes of death in cancer patients

1974 • 597 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Leptin and cancer

2005 • 572 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Androgen receptor signaling in prostate cancer development and progression

2011 • 484 citations

Obesity and Breast Cancer: The Estrogen Connection

2009 • 459 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Tumours with PI3K activation are resistant to dietary restriction

2009 • 448 citations

Insulin signaling meets mitochondria in metabolism

2010 • 401 citations

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

2008 • 395 citations

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

2008 • 388 citations

A high-fat, ketogenic diet induces a unique metabolic state in mice

2007 • 387 citations

The Role of the IGF System in Cancer: From Basic to Clinical Studies and Clinical Applications

2002 • 370 citations

The role of protein in weight loss and maintenance

2015 • 357 citations

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

2015 • 350 citations

Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

2010 • 348 citations

Minireview: IGF, Insulin, and Cancer

2011 • 333 citations

Elevated insulin receptor content in human breast cancer.

1990 • 332 citations

Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans

2007 • 324 citations

SGLT inhibitors in management of diabetes

2013 • 309 citations

A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors

2014 • 293 citations

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

2016 • 283 citations

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

2011 • 278 citations

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

2014 • 265 citations

Adipocytokines and cancer

2006 • 262 citations

IGF2 and cancer

2013 • 260 citations

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

2009 • 250 citations

ERGO: A pilot study of ketogenic diet in recurrent glioblastoma

2014 • 245 citations

Sarcopenia and cachexia in the era of obesity: clinical and nutritional impact

2016 • 243 citations

Energy Balance, Host-Related Factors, and Cancer Progression

2010 • 238 citations

Dual Effect of Metformin on Breast Cancer Proliferation in a Randomized Presurgical Trial

2012 • 232 citations

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

2012 • 232 citations

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

2010 • 227 citations

Hyperinsulinaemia: A prospective risk factor for lethal clinical prostate cancer

2005 • 220 citations

Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases

2007 • 211 citations

Leptin-induced Growth Stimulation of Breast Cancer Cells Involves Recruitment of Histone Acetyltransferases and Mediator Complex to CYCLIN D1 Promoter via Activation of Stat3

2007 • 199 citations

Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme

2014 • 198 citations

Adiponectin as a growth inhibitor in prostate cancer cells

2005 • 196 citations

Effects of adiponectin on breast cancer cell growth and signaling

2008 • 195 citations

Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients

2012 • 185 citations

Prostate Cancer Cell-Adipocyte Interaction

2003 • 182 citations

Obesity, Energy Balance, and Cancer: New Opportunities for Prevention

2012 • 170 citations

Does intentional weight loss reduce cancer risk?

2011 • 168 citations

(Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial

2015 • 162 citations

Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade

2015 • 157 citations

Androgens and obesity

2010 • 149 citations

Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

2015 • 133 citations

Impact of sarcopenia on the prognosis and treatment toxicities in patients diagnosed with cancer

2013 • 131 citations

Antiproliferative and metabolic effects of metformin in a preoperative window clinical trial for endometrial cancer

2014 • 130 citations

Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32

2015 • 124 citations

Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95–2

2007 • 121 citations

Interaction between Adiponectin and Leptin Influences the Risk of Colorectal Adenoma

2010 • 117 citations

Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS^G12D-driven lung tumors

2013 • 112 citations

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

2015 • 106 citations

Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc ( Min/+ ) colon epithelial cell line

2006 • 103 citations

Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

2012 • 100 citations

Serum Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein-3 Concentrations and Prostate Cancer Risk: Results from the European Prospective Investigation into Cancer and Nutrition

2007 • 100 citations

Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer

2014 • 98 citations

A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors

2013 • 98 citations

Insulin receptor expression and clinical outcome in node-negative breast cancer.

1997 • 94 citations

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

2015 • 92 citations

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

2014 • 91 citations

Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation

2015 • 87 citations

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

2015 • 86 citations

Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes

2012 • 86 citations

Expression of insulin-like growth factor 2 in mesenchymal neoplasms

2009 • 82 citations

Measuring the biological effect of presurgical metformin treatment in endometrial cancer

2016 • 79 citations

Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

2011 • 76 citations

Phase 2 Trial of Metformin Combined With 5-Fluorouracil in Patients With Refractory Metastatic Colorectal Cancer

2016 • 72 citations

Improved progression free survival for patients with diabetes and locally advanced non-small cell lung cancer (NSCLC) using metformin during concurrent chemoradiotherapy

2016 • 71 citations

Presurgical Trial of Metformin in Overweight and Obese Patients with Newly Diagnosed Breast Cancer

2014 • 70 citations

Mitochondrial free fatty acid β-oxidation supports oxidative phosphorylation and proliferation in cancer cells

2015 • 65 citations

Obesity and Cortisol Status

2005 • 65 citations

Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2

2012 • 64 citations

Highly specific role of the insulin receptor in breast cancer progression

2015 • 64 citations

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

2011 • 63 citations

Metformin and trametinib have synergistic effects on cell viability and tumor growth inNRASmutant cancer

2014 • 63 citations

Hyperinsulinemia, insulin resistance and colorectal adenomas: A meta-analysis

2015 • 61 citations

Altered Expression of Insulin Receptor Isoforms in Breast Cancer

2011 • 58 citations

The effects of the ketogenic diet in refractory partial seizures with reference to tuberous sclerosis

2006 • 55 citations

Metformin and erlotinib synergize to inhibit basal breast cancer

2014 • 55 citations

Metformin Does Not Reduce Markers of Cell Proliferation in Esophageal Tissues of Patients With Barrett’s Esophagus

2014 • 46 citations

Acyl-Coenzyme A–Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non–Small Cell Lung Cancer

2014 • 45 citations

Phase II trial of metformin and paclitaxel for patients with gemcitabine-refractory advanced adenocarcinoma of the pancreas

2015 • 43 citations

Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery, and apoptosis.

2002 • 42 citations

Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen

2010 • 38 citations

Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

2010 • 38 citations

Metformin and Gynecologic Cancers

2014 • 33 citations

Differential Expression of IR-A, IR-B and IGF-1R in Endometrial Physiology and Distinct Signature in Adenocarcinoma

2016 • 32 citations

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

2014 • 30 citations

Role of genomic imprinting in Wilms' tumour and overgrowth disorders

1996 • 28 citations

Effect of Metformin on Breast Ductal Carcinoma In Situ Proliferation in a Randomized Presurgical Trial

2015 • 28 citations

Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis

2015 • 28 citations

Metformin: risk-benefit profile with a focus on cancer

2015 • 18 citations

Multidrug and toxin extrusion 1 and human organic cation transporter 1 polymorphisms in patients with castration-resistant prostate cancer receiving metformin (SAKK 08/09)

2015 • 13 citations

Proteomic modulation in breast tumors after metformin exposure: results from a “window of opportunity” trial

2016 • 10 citations