Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 859 citations

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

2009 • 789 citations

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

2008 • 757 citations

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

2008 • 659 citations

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

2006 • 650 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 609 citations

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

2011 • 503 citations

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

2010 • 405 citations

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

2001 • 367 citations

Elevated insulin receptor content in human breast cancer.

1990 • 332 citations

Activated Phosphoinositide 3-Kinase/AKT Signaling Confers Resistance to Trastuzumab but not Lapatinib

2010 • 313 citations

PI3K pathway activation in breast cancer is associated with the basal‐like phenotype and cancer‐specific mortality

2009 • 289 citations

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

2010 • 262 citations

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

2010 • 245 citations

Treatment of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Xenografts With Multiagent HER-Targeted Therapy

2007 • 188 citations

Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: A nested case–control study

2009 • 188 citations

Syngeneic mouse mammary carcinoma cell lines: Two closely related cell lines with divergent metastatic behavior

2005 • 188 citations

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

2010 • 154 citations

Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation

2010 • 132 citations

Medical comorbidities predict mortality in women with a history of early stage breast cancer

2010 • 93 citations

Protein Kinase Cζ Mediates Insulin-induced Glucose Transport through Actin Remodeling in L6 Muscle Cells

2006 • 59 citations

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

2010 • 38 citations

Elevated Circulating IGF-I Promotes Mammary Gland Development and Proliferation

2010 • 37 citations

EPITHELIAL AND FIBROBLAST CELL LINES DERIVED FROM A SPONTANEOUS MAMMARY CARCINOMA IN A MMTV/neu TRANSGENIC MOUSE

2002 • 32 citations

Akt inhibitors reduce glucose uptake independently of their effects on Akt

2010 • 26 citations

Functional inhibition of PI3K by the βGBP molecule suppresses Ras–MAPK signalling to block cell proliferation

2007 • 25 citations