A high-fat, ketogenic diet induces a unique metabolic state in mice

Summaries of Affymetrix GeneChip probe level data

2003 • 4,927 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection

2000 • 3,126 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

2005 • 2,774 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

A Randomized Trial of a Low-Carbohydrate Diet for Obesity

2003 • 1,809 citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 • 1,721 citations

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

2004 • 1,610 citations

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

1998 • 1,446 citations

Components of the AIN-93 Diets as Improvements in the AIN-76A Diet

1997 • 1,299 citations

A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity

2003 • 1,267 citations

Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application

2001 • 972 citations

A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia

2004 • 911 citations

A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women

2003 • 834 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

2005 • 602 citations

Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays

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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

2000 • 463 citations

Gene Signatures of Progression and Metastasis in Renal Cell Cancer

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Effects of a Low–Glycemic Load Diet on Resting Energy Expenditure and Heart Disease Risk Factors During Weight Loss

2004 • 331 citations

Numerical Taxonomy

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C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

2002 • 257 citations

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

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Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.

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Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1

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More fat and fewer seizures: dietary therapies for epilepsy

2004 • 168 citations

Food Intake, Energy Balance and Serum Leptin Concentrations in Rats Fed Low-Protein Diets

2000 • 156 citations

The Role of Energy Expenditure in the Differential Weight Loss in Obese Women on Low-Fat and Low-Carbohydrate Diets

2005 • 155 citations

A Ketogenic Diet Increases the Resistance to Pentylenetetrazole‐Induced Seizures in the Rat

1999 • 149 citations

Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms

2005 • 148 citations

Long Term Effects of Ketogenic Diet in Obese Subjects with High Cholesterol Level

2006 • 140 citations

Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data

2005 • 130 citations

Reduced Adiposity and Liver Steatosis by Stearoyl-CoA Desaturase Deficiency Are Independent of Peroxisome Proliferator-activated Receptor-α

2004 • 120 citations

Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses

2005 • 112 citations

Replacement of dietary fat by sucrose or starch: Effects on 14 d ad libitum energy intake, energy expenditure and body weight in formerly obese and never-obese subjects

1997 • 104 citations

Activation of the NPY Y5 receptor regulates both feeding and energy expenditure

1999 • 101 citations

Chronic CNS administration of Agouti-related protein (Agrp) reduces energy expenditure

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Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation

1999 • 95 citations

Comparative analysis of algorithms for signal quantitation from oligonucleotide microarrays

2004 • 94 citations

Contribution of Different Mechanisms to Compensation for Energy Restriction in the Mouse

2005 • 94 citations

Hypothalamic gene expression in long-term fasted rats: relationship with body fat

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MCH−/− Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance

2006 • 60 citations

Ketogenic diet modifies the risk factors of heart disease in obese patients

2003 • 53 citations

Changed Energy State and Increased Mitochondrial β-Oxidation Rate in Liver of Rats Associated with Lowered Proton Electrochemical Potential and Stimulated Uncoupling Protein 2 (UCP-2) Expression

2003 • 50 citations

Quantification of K⁺ secretion through apical low-conductance K channels in the CCD

2005 • 43 citations

Peripherally administered [Nle4,d-Phe7]-α-melanocyte stimulating hormone increases resting metabolic rate, while peripheral agouti-related protein has no effect, in wild type C57BL/6 and ob/ob mice

2004 • 38 citations

Role of Dietary Intervention in the Primary Prevention of Coronary Heart Disease

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Reduction in energy efficiency induced by expression of the uncoupling protein, UCP1, in mouse liver mitochondria

2006 • 22 citations