Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics

2004 • 2,430 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

GoMiner: a resource for biological interpretation of genomic and proteomic data

2003 • 1,211 citations

IRS proteins and the common path to diabetes

2002 • 907 citations

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

2003 • 782 citations

Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra

2004 • 755 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

2003 • 644 citations

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

2005 • 527 citations

Timing Requirements for Insulin/IGF-1 Signaling in C. elegans

2002 • 450 citations

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics

2003 • 414 citations

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

2005 • 372 citations

Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6

2002 • 148 citations

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans

2006 • 125 citations

Calcineurin, a Calcium/Calmodulin-dependent Protein Phosphatase, Is Involved in Movement, Fertility, Egg Laying, and Growth inCaenorhabditis elegans

2002 • 113 citations

Opposing Functions of Calcineurin and CaMKII Regulate G-protein Signaling in Egg-laying Behavior of C.elegans

2004 • 31 citations