Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis

Brown and beige fat: development, function and therapeutic potential

2013 • 2,078 citations

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

2008 • 1,933 citations

Mechanisms for Insulin Resistance: Common Threads and Missing Links

2012 • 1,918 citations

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

2011 • 1,906 citations

Mechanism of free fatty acid-induced insulin resistance in humans.

1996 • 1,507 citations

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

2011 • 935 citations

Obesity and colorectal cancer

2013 • 692 citations

Cancer metabolism: facts, fantasy, and fiction

2003 • 583 citations

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

2013 • 364 citations

Obesity-Related Derangements in Metabolic Regulation

2006 • 349 citations

Depot-related gene expression in human subcutaneous and omental adipocytes.

1998 • 337 citations

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

2013 • 272 citations

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

2009 • 248 citations

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

2011 • 242 citations

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

2010 • 212 citations

How Free Fatty Acids Inhibit Glucose Utilization in Human Skeletal Muscle

2004 • 189 citations

Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications

2012 • 187 citations

Mechanisms of Obesity-Induced Gastrointestinal Neoplasia

2013 • 183 citations

Chronic inflammation and cancer: the role of the mitochondria.

2011 • 168 citations

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis

2011 • 154 citations

Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets

2013 • 152 citations

Genetic insights into OXPHOS defect and its role in cancer

2010 • 147 citations

Effect of High Fat Diets on Energy Balance and Thermogenesis in Brown Adipose Tissue of Lean and Genetically Obese ob/ob Mice

1987 • 135 citations

Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas

1999 • 132 citations

Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal‐transduction pathways

2008 • 130 citations

Brown Adipose Tissue Growth and Development

2013 • 124 citations

The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

2006 • 121 citations

Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks

2010 • 120 citations

Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis

2012 • 105 citations

Worsening of Obesity and Metabolic Status Yields Similar Molecular Adaptations in Human Subcutaneous and Visceral Adipose Tissue: Decreased Metabolism and Increased Immune Response

2010 • 104 citations

Mitochondrial dysfunction in patients with primary congenital insulin resistance

2011 • 89 citations

A high‐fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity‐resistant BALB/c mice

2011 • 82 citations

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer

2014 • 77 citations

Improving efficacy of interleukin‐12‐transfected dendritic cells injected into murine colon cancer with anti‐CD137 monoclonal antibodies and alloantigens

2004 • 68 citations

Adipokines and Obesity Are Associated with Colorectal Polyps in Adult Males: A Cross-Sectional Study

2014 • 63 citations

Putative Role of Adipose Tissue in Growth and Metabolism of Colon Cancer Cells

2014 • 58 citations

Multifaceted Leptin Network: The Molecular Connection Between Obesity and Breast Cancer

2013 • 58 citations

Prolonged Exposure to Insulin Suppresses Mitochondrial Production in Primary Hepatocytes

2009 • 52 citations

Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein

2015 • 42 citations

Adiponectin and leptin molecular actions and clinical significance in breast cancer.

2014 • 39 citations

Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells

2012 • 33 citations

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

2011 • 31 citations

Secreted Human Adipose Leptin Decreases Mitochondrial Respiration in HCT116 Colon Cancer Cells

2013 • 25 citations

Adiponectin and Leptin Molecular Actions and Clinical Significance in Breast Cancer

2014 • 22 citations

Prevention of diabetes-promoted colorectal cancer by (n-3) polyunsaturated fatty acids and (n-3) PUFA mimetic

2014 • 14 citations

Obesity and Breast Cancer: A Multipartite Connection

2013 • 11 citations

Linking obesity to colorectal cancer: Application of nutrigenomics

2010 • 10 citations

Cellular Signal Transduction Pathways by Leptin in Colorectal Cancer Tissue: Preliminary Results

2011 • 6 citations