Does intentional weight loss reduce cancer risk?

Food, nutrition, physical activity, and the prevention of cancer: a global perspective

2008 • 5,159 citations

Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women

2003 • 1,474 citations

Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus

2010 • 1,129 citations

Body Mass Index, Serum Sex Hormones, and Breast Cancer Risk in Postmenopausal Women

2003 • 1,058 citations

Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer

2006 • 826 citations

Dietary Fat Reduction and Breast Cancer Outcome: Interim Efficacy Results From the Women's Intervention Nutrition Study

2006 • 800 citations

Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

2009 • 736 citations

Influence of a Diet Very High in Vegetables, Fruit, and Fiber and Low in Fat on Prognosis Following Treatment for Breast Cancer

2007 • 701 citations

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

2010 • 691 citations

Adult Weight Change and Risk of Postmenopausal Breast Cancer

2006 • 622 citations

Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women

2002 • 548 citations

Endogenous Estrogen, Androgen, and Progesterone Concentrations and Breast Cancer Risk Among Postmenopausal Women

2004 • 500 citations

Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial

2004 • 425 citations

Cancer Incidence and Mortality After Gastric Bypass Surgery

2009 • 377 citations

Association of Gain and Loss of Weight before and after Menopause with Risk of Postmenopausal Breast Cancer in the Iowa Women's Health Study

2005 • 340 citations

Energy Restriction and Weight Loss on Very-Low-Fat Diets Reduce C-Reactive Protein Concentrations in Obese, Healthy Women

2001 • 336 citations

Bariatric surgery reduces cancer risk in morbidly obese patients

2008 • 252 citations

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

2010 • 246 citations

Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor expression

2010 • 236 citations

Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery

2005 • 202 citations

Obesity-related cardiovascular risk factors after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention

2010 • 200 citations

Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention

2002 • 196 citations

Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women

2005 • 192 citations

Intentional weight loss and incidence of obesity-related cancers: the Iowa Women's Health Study

2003 • 191 citations

Effect of a Free Prepared Meal and Incentivized Weight Loss Program on Weight Loss and Weight Loss Maintenance in Obese and Overweight Women

2010 • 172 citations

Health Outcomes of Gastric Bypass Patients Compared to Nonsurgical, Nonintervened Severely Obese

2009 • 143 citations

Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial

2003 • 116 citations

Effect of Weight Loss on Proinflammatory State of Mononuclear Cells in Obese Women

2008 • 116 citations

The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin

2006 • 100 citations

Inflammatory Biomarkers and Physical Function in Older, Obese Adults with Knee Pain and Self‐Reported Osteoarthritis After Intensive Weight‐Loss Therapy

2008 • 98 citations

A 1-Year Lifestyle Intervention for Weight Loss in Individuals With Type 2 Diabetes Reduces High C-Reactive Protein Levels and Identifies Metabolic Predictors of Change

2010 • 97 citations

Effects of a Weight Loss Intervention on Body Mass, Fitness, and Inflammatory Biomarkers in Overweight or Obese Breast Cancer Survivors

2011 • 95 citations

The STEDMAN Project: Biophysical, Biochemical and Metabolic Effects of a Behavioral Weight Loss Intervention during Weight Loss, Maintenance, and Regain

2009 • 94 citations

Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome

2008 • 91 citations

Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery

2002 • 88 citations

Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women

2006 • 85 citations

Increases in Adiponectin Predict Improved Liver, but Not Peripheral, Insulin Sensitivity in Severely Obese Women During Weight Loss

2007 • 82 citations

Low Carbohydrate, High Fat Diet Increases C-Reactive Protein during Weight Loss

2007 • 74 citations

Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women

2005 • 72 citations

CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects

2005 • 71 citations

Effects of gastric bypass on the GH/IGF-I axis in severe obesity – and a comparison with GH deficiency

2005 • 67 citations

The Relationships Between IGF-1 and CRP, NO, Leptin, and Adiponectin During Weight Loss in the Morbidly Obese

2010 • 67 citations

One Year Improvements in Cardiovascular Risk Factors: a Comparative Trial of Laparoscopic Roux-en-Y Gastric Bypass vs. Adjustable Gastric Banding

2010 • 57 citations

Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects

2009 • 56 citations

Decreasing levels of tumour necrosis factor α and interleukin 6 during lowering of body mass index with orlistat or placebo in obese subjects with cardiovascular risk factors

2003 • 52 citations

Moderate energy restriction-induced weight loss affects circulating IGF levels independent of dietary composition

2010 • 50 citations

Renal cytokines improve early after bariatric surgery

2010 • 43 citations

Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery

2010 • 39 citations

Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss

2008 • 39 citations

Pro- and mature IGF-II during diet-induced weight loss in obese subjects

2005 • 31 citations

Relationship of Androgens to Insulin Resistance and Chronic Inflammation in Morbidly Obese Premenopausal Women: Studies before and after Vertical Banded Gastroplasty

2006 • 28 citations

GH and IGF‐I deficiency are associated with reduced loss of fat mass after laparoscopic‐adjustable silicone gastric banding

2008 • 24 citations

Energy balance, early life body size, and plasma prolactin levels in postmenopausal women

2008 • 16 citations

Relationship between Insulin and Sex Hormone-Binding Globulin Levels during Weight Loss in Obese Women

2007 • 7 citations