The insulin and insulin-like growth factor receptor family in neoplasia: an update

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

2010 • 4,281 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

2006 • 2,463 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Diabetes and Cancer

2010 • 2,066 citations

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

2000 • 1,929 citations

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

2010 • 1,614 citations

Insulin-like growth factors and neoplasia

2004 • 1,452 citations

AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function

2011 • 1,446 citations

Immortal Time Bias in Pharmacoepidemiology

2007 • 1,414 citations

Targeting cancer metabolism: a therapeutic window opens

2011 • 1,344 citations

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

2010 • 1,218 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

2010 • 1,122 citations

Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

2006 • 1,038 citations

Diabetes and Cancer: A Consensus Report

2010 • 993 citations

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

2009 • 992 citations

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

2011 • 921 citations

Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

2007 • 903 citations

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

2007 • 894 citations

Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)

2001 • 868 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 859 citations

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

2000 • 734 citations

Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study

2002 • 609 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

2004 • 544 citations

The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

2011 • 533 citations

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

2010 • 509 citations

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.

2002 • 508 citations

Tumours with PI3K activation are resistant to dietary restriction

2009 • 448 citations

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

2003 • 439 citations

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

2008 • 424 citations

Cyclic Oscillations of Basal Plasma Glucose and Insulin Concentrations in Human Beings

1979 • 402 citations

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

2008 • 395 citations

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

2009 • 383 citations

Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer

2004 • 373 citations

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

2002 • 370 citations

Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth

2004 • 364 citations

Genetic analysis of insulin signaling in Drosophila

2002 • 359 citations

Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.

1997 • 343 citations

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

2012 • 335 citations

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

2009 • 334 citations

A Prospective Study of Plasma C-Peptide and Colorectal Cancer Risk in Men

2004 • 333 citations

Minireview: IGF, Insulin, and Cancer

2011 • 333 citations

Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

1996 • 330 citations

Insulin and its receptor: structure, function and evolution

2004 • 317 citations

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

2009 • 269 citations

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

2010 • 233 citations

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

2010 • 231 citations

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

2011 • 229 citations

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

2010 • 227 citations

Hormone responsive human breast cancer in long-term tissue culture: effect of insulin.

1976 • 222 citations

Insulin receptor expression by human prostate cancers

2008 • 220 citations

Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors

2008 • 205 citations

Insulin‐like growth factor (IGF)‐I rescues breast cancer cells from chemotherapy‐induced cell death – proliferative and anti‐apoptotic effects

1999 • 192 citations

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

2007 • 192 citations

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

2008 • 185 citations

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

2010 • 178 citations

Association of Diet-Induced Hyperinsulinemia With Accelerated Growth of Prostate Cancer (LNCaP) Xenografts

2007 • 176 citations

Influence of Unrecognized Molecular Heterogeneity on Randomized Clinical Trials

2002 • 165 citations

Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure

2010 • 164 citations

Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation.

1996 • 160 citations

Down-regulation of Type I Insulin-like Growth Factor Receptor Increases Sensitivity of Breast Cancer Cells to Insulin

2007 • 157 citations

A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

2011 • 155 citations

Insulin glargine and malignancy: an unwarranted alarm

2009 • 148 citations

Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC).

2010 • 121 citations

A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors

2011 • 120 citations

Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

2011 • 118 citations

Insulin Increases De Novo Steroidogenesis in Prostate Cancer Cells

2011 • 109 citations

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

2009 • 101 citations

Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk

2006 • 96 citations

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

2011 • 96 citations

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

2011 • 89 citations

Randomized Trial of Tamoxifen Versus Combined Tamoxifen and Octreotide LAR Therapy in the Adjuvant Treatment of Early-Stage Breast Cancer in Postmenopausal Women: NCIC CTG MA.14

2011 • 88 citations

Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab

2010 • 86 citations

Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: clinical activity and molecular response (GORTEC 2008-02)

2012 • 75 citations

Gefitinib resistance in HCC mahlavu cells: Upregulation of CD133 expression, activation of IGF‐1R signaling pathway, and enhancement of IGF‐1R nuclear translocation

2011 • 67 citations

ETV6-NTRK3–Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway

2010 • 66 citations

Synthetic Lethality Screens Reveal RPS6 and MST1R as Modifiers of Insulin-like Growth Factor-1 Receptor Inhibitor Activity in Childhood Sarcomas

2010 • 64 citations

Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs

2006 • 63 citations

Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer

2011 • 60 citations

Insulin X10 revisited: a super-mitogenic insulin analogue

2011 • 58 citations

Tacrolimus‐Induced Diabetes in Rats Courses with Suppressed Insulin Gene Expression in Pancreatic Islets

2007 • 57 citations

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics

2011 • 57 citations

Increased Insulin-Like Growth Factor 1 Receptor Protein Expression and Gene Copy Number in Small Cell Lung Cancer

2010 • 54 citations

Inhaled insulin's last gasp?

2008 • 53 citations

Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines

2009 • 49 citations

Metformin abolishes increased tumor¹⁸F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet

2011 • 39 citations

Figitumumab combined with carboplatin and paclitaxel in treatment-naïve Japanese patients with advanced non-small cell lung cancer

2011 • 32 citations

IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer

2011 • 32 citations

Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models

2010 • 18 citations

Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use- compilation of reports from the past 20 years

2011 • 14 citations

Abstract 2465: Gene expression, phenotypic and karyotypic analyses of stepwise prostate carcinogenesis in vitro

2010 • 9 citations

Effect of baseline (BL) biomarkers on overall survival (OS) in metastatic pancreatic cancer (mPC) patients (pts) treated with ganitumab (GAN; AMG 479) or placebo (P) in combination with gemcitabine (G).

2011 • 7 citations