Leptin-induced Growth Stimulation of Breast Cancer Cells Involves Recruitment of Histone Acetyltransferases and Mediator Complex to CYCLIN D1 Promoter via Activation of Stat3

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

STATs and Gene Regulation

1997 • 3,927 citations

Stat3 as an Oncogene

1999 • 2,770 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

2003 • 1,192 citations

Molecular Determinants for the Tissue Specificity of SERMs

2002 • 1,114 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Minireview: Cyclin D1: Normal and Abnormal Functions

2004 • 939 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

1999 • 841 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

The biology of white adipocyte proliferation

2001 • 681 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.

1995 • 522 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

2005 • 501 citations

Obesity, adipocytokines, and insulin resistance in breast cancer

2004 • 458 citations

Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer

2004 • 431 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

1994 • 377 citations

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

2003 • 346 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Leptin signaling

2004 • 287 citations

Adipocytokines and cancer

2006 • 262 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3

2006 • 257 citations

Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience

2004 • 254 citations

Cyclins and Breast Cancer

2004 • 251 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions

2003 • 223 citations

Determination of the prognostic value of cyclin D1 overexpression in breast cancer.

1995 • 215 citations

Leptin: a multifunctional hormone

2000 • 211 citations

Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer.

1999 • 210 citations

Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation

2004 • 207 citations

Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes

2006 • 196 citations

Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways

2006 • 170 citations

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy

2004 • 167 citations

Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo

2002 • 157 citations

Release of Methyl CpG Binding Proteins and Histone Deacetylase 1 from the Estrogen Receptor α (ER) Promoter upon Reactivation in ER-Negative Human Breast Cancer Cells

2005 • 151 citations

Genetically Obese MMTV-TGF-α/Lep ob Lep ob Female Mice do not Develop Mammary Tumors

2003 • 148 citations

Leptin Receptor-Deficient MMTV-TGF-α/Lepr^db Lepr^db Female Mice Do Not Develop Oncogene-Induced Mammary Tumors

2004 • 138 citations

Activating Transcription Factor 3 Induces DNA Synthesis and Expression of Cyclin D1 in Hepatocytes

2001 • 114 citations

Identification of the Critical Sequence Elements in the Cytoplasmic Domain of Leptin Receptor Isoforms Required for Janus Kinase/Signal Transducer and Activator of Transcription Activation by Receptor Heterodimers

2002 • 100 citations

Phosphorylation of Transcriptional Coactivator Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein (PBP)

2002 • 73 citations

Development of leptin antagonists and their potential use in experimental biology and medicine

2006 • 60 citations

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

2002 • 49 citations

Leptin — From regulation of fat metabolism to stimulation of breast cancer growth

2006 • 49 citations

Obesity: an endocrine tumor?

2004 • 48 citations

Obesity

2006 • 37 citations

Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer

2003 • 30 citations

Distinct Roles of the Steroid Receptor Coactivator 1 and of MED1 in Retinoid-induced Transcription and Cellular Differentiation

2006 • 22 citations

Welcome from the new Editor-in-Chief

2006 • 8 citations