Prostate Cancer Cell-Adipocyte Interaction

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo¹

1997 • 1,993 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid¹

1998 • 1,562 citations

Biological Action of Leptin as an Angiogenic Factor

1998 • 1,390 citations

Interleukin-6-deficient mice develop mature-onset obesity

2002 • 1,197 citations

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation

2001 • 969 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

2001 • 772 citations

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

1996 • 751 citations

Leptin, the Product of Ob Gene, Promotes Angiogenesis

1998 • 721 citations

Leptin induces oxidative stress in human endothelial cells

1999 • 682 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 as Predictors of Advanced-Stage Prostate Cancer

2002 • 444 citations

Translational control of C/EBP alpha and C/EBP beta isoform expression

2000 • 403 citations

Translational control of C/EBPα and C/EBPβ isoform expression

2000 • 402 citations

Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells

1997 • 386 citations

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

2001 • 362 citations

Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States.

2001 • 320 citations

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.

1997 • 308 citations

Direct Intraovarian Effects of Leptin: Impairment of the Synergistic Action of Insulin-Like Growth Factor-I on Follicle-Stimulating Hormone-Dependent Estradiol-17β Production by Rat Ovarian Granulosa Cells*

1997 • 307 citations

Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair

2000 • 302 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Leptin mediates a proliferative response in human MCF7 breast cancer cells

2002 • 287 citations

Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer

1999 • 285 citations

1. Signal transduction by the c-Jun N-terminal kinase

1999 • 264 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Characterization of the role of IL-6 in the progression of prostate cancer

1999 • 226 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

Wnt Signaling Protects 3T3-L1 Preadipocytes from Apoptosis through Induction of Insulin-like Growth Factors

2002 • 211 citations

Leptin Is Associated with Increased Prostate Cancer Risk: A Nested Case-Referent Study¹

2001 • 199 citations

Expression of leptin and leptin receptor isoforms in the human stomach

2000 • 192 citations

Body size and prostate cancer: a population-based case-control study in China.

2000 • 161 citations

Relationship between obesity and race in predicting adverse pathologic variables in patients undergoing radical prostatectomy

2001 • 130 citations

TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells

2001 • 127 citations

Systemically and Topically Administered Leptin Both Accelerate Wound Healing in Diabetic ob/ob Mice

2000 • 117 citations

Interleukin-6 Induces G1Arrest through Induction of p27Kip1, a Cyclin-Dependent Kinase Inhibitor, and Neuron-like Morphology in LNCaP Prostate Tumor Cells

1999 • 102 citations

TUMOR NECROSIS FACTOR-α REPRESSES ANDROGEN SENSITIVITY IN THE LNCaP PROSTATE CANCER CELL LINE

2000 • 97 citations

Risk factors for prostate cancer.

1995 • 93 citations

Energy Imbalance and Prostate Cancer

2002 • 66 citations

Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.

2002 • 53 citations

Leptin Stimulates Insulin Secretion and Synthesis in HIT-T 15 Cells

1997 • 41 citations

Smoking and Obesity in Relation to the Etiology and Disease Progression of Prostate Cancer in Japan

1998 • 36 citations

IGF-I and IGF-Binding Proteins: Stimulatory and Inhibitory Factors Secreted by Human Prostatic Adenocarcinoma Cells

1991 • 31 citations