IGF2 and cancer

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

The Journal of Laboratory and Clinical Medicine

2003 • 1,534 citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

2000 • 1,414 citations

Clinical Cancer Research

1941 • 1,358 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions*

1997 • 1,056 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Insulin‐like growth factors I and II

1990 • 1,006 citations

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

2009 • 992 citations

New Users of Metformin Are at Low Risk of Incident Cancer

2009 • 974 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Benign Breast Disease and the Risk of Breast Cancer

2005 • 873 citations

Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells

1999 • 865 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

Birth Defects Original Article Series

1970 • 783 citations

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

2003 • 740 citations

Gli and hedgehog in cancer: tumours, embryos and stem cells

2002 • 709 citations

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

1981 • 595 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 515 citations

Insulin-like growth factor binding proteins and their role in controlling IGF actions

1997 • 510 citations

Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved

2002 • 492 citations

Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics

1996 • 483 citations

Obesity and cancer risk: the role of the insulin–IGF axis

2006 • 463 citations

Serum levels of insulin-like growth factor I and its binding proteins in health and disease

2003 • 448 citations

Epidemiology and aetiology of gestational trophoblastic diseases

2003 • 403 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

1963 • 399 citations

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions

1997 • 396 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia

1988 • 346 citations

Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

1996 • 330 citations

The proliferating role of insulin and insulin-like growth factors in cancer

2010 • 329 citations

Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome

1997 • 325 citations

Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

2013 • 322 citations

Free insulin‐like growth factors (IGF‐I and IGF‐II) in human serum

1994 • 310 citations

Molecules in focus Insulin-like growth factor II (IGF-II)

1998 • 304 citations

Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome

2004 • 297 citations

The Link between the Metabolic Syndrome and Cancer

2011 • 296 citations

Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors.

2001 • 288 citations

Circulating levels of free insulin-like growth factors in obese subjects: the impact of Type 2 diabetes

1999 • 287 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

2009 • 269 citations

The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system

2001 • 261 citations

Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse

2013 • 261 citations

Insulin receptor and cancer

2011 • 260 citations

Role of insulin-like growth factor 1 receptor signalling in cancer

2005 • 241 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

Insulin resistance and cancer: the role of insulin and IGFs

2012 • 239 citations

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

1999 • 238 citations

Patched Target Igf2 Is Indispensable for the Formation of Medulloblastoma and Rhabdomyosarcoma

2000 • 231 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

Single‐cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT‐related genes in metastatic prostate cancer

2012 • 220 citations

A Novel Autocrine Loop Involving IGF-II and the Insulin Receptor Isoform-A Stimulates Growth of Thyroid Cancer

2002 • 216 citations

Variables Controlling the Secretion of Insulin-Like Growth Factor Binding Protein-2 in Normal Human Subjects*

1991 • 213 citations

Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases

2007 • 211 citations

Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer

2010 • 208 citations

Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma.

1998 • 192 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Insulin-like growth factors (IGF-I, free IGF-I, and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation

1999 • 187 citations

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

2010 • 178 citations

Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia

2006 • 173 citations

Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

1992 • 168 citations

Does intentional weight loss reduce cancer risk?

2011 • 168 citations

Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain.

1976 • 161 citations

In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

2002 • 156 citations

Insulin-like Growth Factor Binding Protein-3 Induces Apoptosis in MCF7 Breast Cancer Cells

1997 • 152 citations

IGF2 DNA methylation is a modulator of newborn’s fetal growth and development

2012 • 145 citations

Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring

2013 • 144 citations

Blockade of the insulin‐like growth‐factor‐I receptor inhibits growth of human colorectal cancer cells: Evidence of a functional IGF‐II‐mediated autocrine loop

1994 • 143 citations

Single Nucleotide Polymorphisms

2009 • 137 citations

Insulin-like growth factor II-mediated proliferation of human neuroblastoma.

1991 • 135 citations

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

2011 • 131 citations

Frequent IGF2/H19 Domain Epigenetic Alterations and Elevated IGF2 Expression in Epithelial Ovarian Cancer

2006 • 130 citations

Consequences of growth hormone (GH) overexpression and GH resistance

2002 • 127 citations

Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition☆

2004 • 123 citations

Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells

2002 • 121 citations

Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

2011 • 118 citations

Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia.

1995 • 117 citations

Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

1996 • 114 citations

Distinct and Overlapping Functions of Insulin and IGF-I Receptors

2001 • 114 citations

IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells

2007 • 112 citations

Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer

2000 • 111 citations

Insulin Increases De Novo Steroidogenesis in Prostate Cancer Cells

2011 • 109 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight

2012 • 104 citations

Enhanced sensitivity to IGF-II signaling links loss of imprinting ofIGF2to increased cell proliferation and tumor risk

2007 • 103 citations

Glucocorticoid therapy suppresses abnormal secretion of big IGF‐II by non‐islet cell tumours inducing hypoglycaemia (NICTH)

1998 • 102 citations

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

2009 • 101 citations

Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure

2009 • 100 citations

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

1996 • 99 citations

Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia.

1999 • 99 citations

Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing.

1993 • 99 citations

Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma

2003 • 99 citations

Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

2010 • 98 citations

Regulation of insulin-like growth factor (IGF) II and IGF binding protein 3 autocrine loop in human PC-3 prostate cancer cells by vitamin D metabolite 1,25(OH)2D3 and its analog EB1089.

1998 • 98 citations

Tumours producing hypoglycaemia

1998 • 96 citations

Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function

2006 • 93 citations

Imprinted genes in liver carcinogenesis

1997 • 92 citations

The Role of IGF-1R in Pediatric Malignancies

2009 • 90 citations

Purification and Characterization of a Unique High Molecular Weight Form of Insulin-Like Growth Factor II

1987 • 90 citations

Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab

2010 • 86 citations

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway

2012 • 84 citations

Effects of Insulin-Like Growth Factors (IGFs) and IGF Receptor Antibodies on the Proliferation of Human Breast Cancer Cells

1992 • 83 citations

Changes in the IGF–IGFBP axis in critical illness

2001 • 83 citations

Expression of insulin-like growth factor 2 in mesenchymal neoplasms

2009 • 82 citations

Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia

1998 • 82 citations

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

2012 • 81 citations

Serum Insulin-Like Growth Factor II in 44 Patients with Non-Islet Cell Tumor Hypoglycemia

1998 • 81 citations

Loss of Imprinting ofIGF2as an Epigenetic Marker for the Risk of Human Cancer

2007 • 79 citations

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesis

2012 • 79 citations

Increased levels of circulating free insulin-like growth factors in patients with non-islet cell tumour hypoglycaemia

1998 • 79 citations

Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro

1999 • 78 citations

Gastric cancer: the role of insulin‐like growth factor 2 (IGF 2) and its receptors (IGF 1R and M6‐P/IGF 2R)

2003 • 77 citations

Angiogenic growth factors in preinvasive breast disease.

1999 • 75 citations

Targeting the insulin-like growth factor network in cancer therapy

2011 • 75 citations

Insulin-Like Growth Factors Promote Vasculogenesis in Embryonic Stem Cells

2012 • 73 citations

Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia

1998 • 71 citations

Clinical Utility of Insulin-Like Growth Factor 1 and 2; Determination by High Resolution Mass Spectrometry

2012 • 70 citations

Glucose utilization in a patient with hepatoma and hypoglycemia. Assessment by a positron emission tomography.

1992 • 69 citations

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice.

1998 • 68 citations

Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland

2003 • 67 citations

Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.

1996 • 66 citations

Loss of Imprinting of Human Insulin-like Growth Factor II Gene, IGF2, in Acute Myeloid Leukemia

1997 • 66 citations

Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2

2012 • 64 citations

Modulating Uranium Binding Affinity in Engineered Calmodulin EF-Hand Peptides: Effect of Phosphorylation

2012 • 63 citations

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

2011 • 63 citations

Periconceptional nutrition and the early programming of a life of obesity or adversity

2010 • 60 citations

Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3

2009 • 60 citations

Bi-directional Regulation of Brown Fat Adipogenesis by the Insulin Receptor

2003 • 59 citations

Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma

2011 • 59 citations

Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue

2005 • 58 citations

Non‐islet cell tumour‐associated hypoglycaemia: ¹¹¹In‐octreotide imaging and efficacy of octreotide, growth hormone and glucocorticosteroids

1996 • 58 citations

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice

1998 • 57 citations

A Novel Autocrine Loop Involving IGF-II and the Insulin Receptor Isoform-A Stimulates Growth of Thyroid Cancer

2002 • 56 citations

Genomic imprinting: the influence of differential methylation in the two sexes

2010 • 56 citations

Serum Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins, and Breast Cancer Risk in Postmenopausal Women

2004 • 56 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

1994 • 55 citations

Synthetic low-calcaemic vitamin D3 analogues inhibit secretion of insulin-like growth factor II and stimulate production of insulin-like growth factor-binding protein-6 in conjunction with growth suppression of HT-29 colon cancer cells

2001 • 53 citations

Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor.

2003 • 52 citations

Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6

2000 • 52 citations

Beck-Wiedemann syndrome and Wilms' tumour

1997 • 52 citations

Measurement of derivatives of proinsulin-like growth factor-II in serum by a radioimmunoassay directed against the E-domain in normal subjects and patients with nonislet cell tumor hypoglycemia.

1992 • 52 citations

Research Resource: New and Diverse Substrates for the Insulin Receptor Isoform A Revealed by Quantitative Proteomics After Stimulation With IGF-II or Insulin

2011 • 51 citations

M6P/IGF2Rloss of heterozygosity in head and neck cancer associated with poor patient prognosis

2003 • 51 citations

Moderate energy restriction-induced weight loss affects circulating IGF levels independent of dietary composition

2010 • 50 citations

Insulin-like Growth Factors in Pediatric Health and Disease

1999 • 49 citations

Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75

1993 • 49 citations

Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability

1996 • 49 citations

Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3

2011 • 48 citations

IGFs: function and clinical importance 3 Role of insulin‐like growth factor (IGF) II and IGF binding proteins in extrapancreatic tumour hypoglycaemia

1993 • 48 citations

IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

2012 • 48 citations

IGF2 increases de novo steroidogenesis in prostate cancer cells

2013 • 48 citations

A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells

2004 • 47 citations

Blastemal Expression of Type I Insulin-Like Growth Factor Receptor in Wilms' Tumors Is Driven by Increased Copy Number and Correlates with Relapse

2006 • 47 citations

Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia

1995 • 47 citations

IGF‐II Binding to Insulin Receptor Isoform A Induces a Partially Different Gene Expression Profile from Insulin Binding

2004 • 46 citations

p53 Regulates Human Insulin-Like Growth Factor II Gene Expression through Active P4 Promoter in Rhabdomyosarcoma Cells

1998 • 45 citations

Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3

2013 • 45 citations

Hypoglycaemia associated with the production of insulin‐like growth factor II and insulin‐like growth factor binding protein 6 by a haemangiopericytoma

1999 • 45 citations

Effects of Insulin-Like Growth Factors I and II on Growth and Differentiation of Transplanted Rat Embryos and Fetal Tissues*

1989 • 45 citations

Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues

2009 • 45 citations

Insulin-like growth factors and non-islet cell tumor hypoglycemia

1993 • 43 citations

Vitamin C suppresses proliferation of the human melanoma cell SK‐MEL‐2 through the inhibition of cyclooxygenase‐2 (COX‐2) expression and the modulation of insulin‐like growth factor II (IGF‐II) production

2008 • 42 citations

Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity

2010 • 39 citations

Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

2010 • 38 citations

Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in Adult Patients with Severe Liver Disease before and after Orthotopic Liver Transplantation

2002 • 38 citations

Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer

2012 • 37 citations

Interactions between Plasma Levels of 25-Hydroxyvitamin D, Insulin-Like Growth Factor (IGF)-1 and C-Peptide with Risk of Colorectal Cancer

2011 • 37 citations

The expression and role of insulin-like growth factor II in malignant hemangiopericytomas

1999 • 36 citations

A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

2013 • 36 citations

Insulin-like growth factor II and colorectal cancer risk in women.

2002 • 36 citations

Serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer

2011 • 36 citations

Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells

2000 • 33 citations

The prevalence of loss of imprinting of H19 and IGF2 at birth

2013 • 33 citations

Non‐islet cell tumour induced hypoglycaemia with acromegaloid facial and aral swelling

1995 • 33 citations

Insulin-like growth factors I and II receptors in the breast cancer survival disparity among African–American women

2010 • 32 citations

Pro- and mature IGF-II during diet-induced weight loss in obese subjects

2005 • 31 citations

Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial

2013 • 30 citations

Elevated insulin-like growth factor (IGF) binding protein (IGFBP)-2 and IGFBP-4 expression of leukemic T-cells is affected by autocrine/paracrine IGF-II action but not by IGF type I receptor expression

1998 • 30 citations

Elevated free IGF2 levels in localized, early-stage breast cancer in women

2008 • 30 citations

Serum insulin-like growth factor (IGF)-II is more closely associated with liver dysfunction than is IGF-I in patients with cirrhosis

2000 • 30 citations

Insulin-Like Growth Factor Binding Protein-3 Concentrations and Insulin-Like Growth Factor Binding Protein-3 Protease Activity in Sera of Patients with Malignant Solid Tumors or Leukemia

1994 • 28 citations

Insulin-like growth factor-II participates in the biphasic effect of a gonadotropin-releasing hormone agonist on ovarian cancer cell growth

1997 • 28 citations

Dose-related effects of growth hormone on IGF-I and IGF-binding protein-3 levels in non-islet cell tumour hypoglycaemia

1998 • 28 citations

Role of genomic imprinting in Wilms' tumour and overgrowth disorders

1996 • 28 citations

IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma

2006 • 28 citations

Molecular Pathways Involved in the Antineoplastic Effects of Calcitriol on Insulinoma Cells

2003 • 27 citations

Defective Expression of Prohormone Convertase 4 and Enhanced Expression of Insulin-like Growth Factor II by Pleural Solitary Fibrous Tumor Causing Hypoglycemia

2008 • 27 citations

Measurement of derivatives of proinsulin-like growth factor-II in serum by a radioimmunoassay directed against the E-domain in normal subjects and patients with nonislet cell tumor hypoglycemia

1992 • 26 citations

beta-Thalassemia in Southern Italy: a preliminary approach.

1982 • 25 citations

Inhibition of autocrine IGF-II on effect of human HepG2 cell proliferation and angiogenesis factor expression

2012 • 25 citations

Heterogeneity of serum peptides with immunoactivity detected by a radioimmunoassay for proinsulin-like growth factor-II E domain: description of a free E domain peptide in serum.

1992 • 25 citations

Levels of plasma insulin-like growth factor I (IGF I), IGF II, IGF binding proteins, type 1 IGF receptor and growth hormone binding protein in community-dwelling elderly subjects with no malnutrition and no inflammation.

2003 • 24 citations

Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma

2008 • 23 citations

Plasma insulin-like growth factor binding protein-3 proteolysis is increased in primary breast cancer

2001 • 22 citations

Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients

2011 • 22 citations

The Role for Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

2011 • 22 citations

The mannose 6‐phosphate/insulin‐like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells

2008 • 22 citations

Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells

1996 • 19 citations

Mature IGF-II prevents the formation of “big” IGF-II/IGFBP-2 complex in the human circulation

2009 • 19 citations

CONTROL OF HYPOGLYCEMIA WITH DIAZOXIDE AND HORMONES*

1968 • 19 citations

The correlation between zinc and insulin-like growth factor 1 (IGF-1), its binding protein (IGFBP-3) and prostate-specific antigen (PSA) in prostate cancer

2011 • 18 citations

Precursor Igf-ii (Proigf-ii) And Mature Igf-ii (Migf-ii) Induce Bcl-2 And Bcl-x_lExpression Through Different Signaling Pathways In Breast Cancer Cells

2008 • 18 citations

IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.

2012 • 18 citations

Free Insulin-Like Growth Factor (IGF) in Disorders of IGF Binding Protein 3 Complex Formation

2004 • 17 citations

Molecular signatures and prognosis of hepatocellular carcinoma.

2011 • 17 citations

Insulin-like growth factor 2 gene methylation in peripheral blood mononuclear cells of patients with hepatitis C related cirrhosis or hepatocellular carcinoma

2012 • 16 citations

Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer

2011 • 16 citations

‘Big’-Insulin-Like Growth Factor–II Signaling Is an Autocrine Survival Pathway in Gastrointestinal Stromal Tumors

2012 • 16 citations

IGF2RGenetic Variants, Circulating IGF2 Concentrations and Colon Cancer Risk in African Americans and Whites

2012 • 15 citations

Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma

2011 • 13 citations

Insulin-like Growth Factors in Pediatric Health and Disease

1999 • 12 citations

Targeted tumor gene therapy based on loss of IGF2 imprinting

2010 • 12 citations

Insulin-like growth factor-II is a useful marker to detect hepatocellular carcinoma?

2012 • 12 citations

Relaxed imprinting of IGF2 in peripheral blood cells of patients with a history of prostate cancer

2012 • 10 citations

IGF2R Missense Single-Nucleotide Polymorphisms and Breast Cancer Risk: The Multiethnic Cohort Study

2009 • 10 citations

Heterogeneity of serum peptides with immunoactivity detected by a radioimmunoassay for proinsulin-like growth factor-II E domain: description of a free E domain peptide in serum

1992 • 9 citations

Retraction Note: Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab

2012 • 8 citations

The insulin-like growth factor-system in a patient with diffuse large B-cell non-Hodgkin's lymphoma and lactic acidosis

2013 • 7 citations

A case of spontaneous hypoglycaemia and impaired glucose tolerance in the same patient

2011 • 7 citations

Voices from the front: July

2012 • 1 citations

Deleted Work

1955 • 0 citations