Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

2011 • 5,649 citations

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

2005 • 5,086 citations

Molecular mechanisms and clinical applications of angiogenesis

2011 • 4,841 citations

Triple-Negative Breast Cancer

2010 • 3,588 citations

Targeting hypoxia in cancer therapy

2011 • 2,837 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

2011 • 1,483 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo

2001 • 1,202 citations

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

2000 • 1,026 citations

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

2009 • 783 citations

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

2003 • 557 citations

Tumour immunity: effector response to tumour and role of the microenvironment

2008 • 511 citations

Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice

2009 • 387 citations

Estrogen Receptors: Therapies Targeted to Receptor Subtypes

2010 • 354 citations

Estrogen and Angiogenesis

2001 • 330 citations

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

2011 • 299 citations

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

2007 • 287 citations

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

2004 • 284 citations

Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis

2004 • 279 citations

Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?

2011 • 277 citations

Estradiol enhances primary antigen‐specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor α expression in hematopoietic cells

2003 • 266 citations

Estrogen—the Good, the Bad, and the Unexpected

2005 • 252 citations

Tie2-Expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2

2007 • 249 citations

Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses

2010 • 218 citations

Estrogen Receptors and Endothelium

2010 • 204 citations

Estrogen Receptor β Inhibits Angiogenesis and Growth of T47D Breast Cancer Xenografts

2006 • 202 citations

Systemic Stromal Effects of Estrogen Promote the Growth of Estrogen Receptor–Negative Cancers

2007 • 174 citations

Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors

2008 • 170 citations

Chronic Estradiol Administration In Vivo Promotes the Proinflammatory Response of Macrophages to TLR4 Activation: Involvement of the Phosphatidylinositol 3-Kinase Pathway

2008 • 168 citations

Effect of estrogen on endothelial function and angiogenesis

2002 • 157 citations

Clinico-pathological characteristics of BRCA1- and BRCA2-related breast cancer

2000 • 148 citations

Evidence for incorporation of bone marrow–derived endothelial cells into perfused blood vessels in tumors

2005 • 145 citations

Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-γ production by invariant natural killer T cells

2004 • 144 citations

Estrogens and the Vascular Endothelium

2002 • 142 citations

Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice.

1996 • 124 citations

Endothelial Estrogen Receptor-α Plays a Crucial Role in the Atheroprotective Action of 17β-Estradiol in Low-Density Lipoprotein Receptor–Deficient Mice

2009 • 100 citations

Correction of RT–qPCR data for genomic DNA-derived signals with ValidPrime

2012 • 85 citations

Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring

2010 • 58 citations

Mesenchymal Stem Cells in the Pathogenesis and Therapy of Breast Cancer

2010 • 56 citations

Soluble forms of VEGF receptor‐1 and ‐2 promote vascular maturationviamural cell recruitment

2010 • 51 citations

Estrogen Receptor α Expression in Both Endothelium and Hematopoietic Cells Is Required for the Accelerative Effect of Estradiol on Reendothelialization

2009 • 50 citations

Estrogen regulation of thrombospondin‐1 in human breast cancer cells

2009 • 43 citations

The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status

2000 • 37 citations

Tamoxifen for patients with estrogen receptor-negative breast cancer.

2001 • 32 citations

Oestradiol stimulates growth of oestrogen receptor-negative MDA-MB-231 breast cancer cells in immunodeficient mice by reducing cell loss

1994 • 21 citations

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause

2011 • 16 citations

Lung Cancer May Be Different for Men and Women, But Researchers Ponder What To Do?

2007 • 9 citations