Role of Fibroblasts and Myofibroblasts in Idiopathic Pulmonary Fibrosis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy

2001 • 1,727 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

1997 • 1,010 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Interleukin-13 Induces Tissue Fibrosis by Selectively Stimulating and Activating Transforming Growth Factor β1

2001 • 896 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Transforming growth factor-beta: recent progress and new challenges.

1992 • 781 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line.

1989 • 753 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment process

1977 • 695 citations

Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung.

1990 • 678 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 • 671 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Interleukin 6 Is Required for the Development of Collagen-induced Arthritis

1998 • 605 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2–dominated inflammatory response

1999 • 601 citations

A Preliminary Study of Long-Term Treatment with Interferon Gamma-1b and Low-Dose Prednisolone in Patients with Idiopathic Pulmonary Fibrosis

1999 • 585 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Mechanisms of Myofibroblast Activity and Phenotypic Modulation

1999 • 580 citations

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function.

1993 • 565 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

The cell biology of transforming growth factor β

1990 • 537 citations

Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

1986 • 528 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes.

1992 • 509 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins.

1989 • 473 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.

1986 • 458 citations

Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis.

1994 • 444 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

Costimulation of Fibroblast Collagen and Transforming Growth Factor β1 Gene Expression by Monocyte Chemoattractant Protein-1 via Specific Receptors

1996 • 427 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Water transport revisited

1999 • 423 citations

Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor.

1989 • 422 citations

Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis

1987 • 420 citations

TIMP-1, -2, -3, and -4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment?

2000 • 412 citations

The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

1991 • 406 citations

Schistosome Infection of Transgenic Mice Defines Distinct and Contrasting Pathogenic Roles for IL-4 and IL-13: IL-13 Is a Profibrotic Agent

2000 • 402 citations

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats

1998 • 402 citations

The role of IL-13 and its receptor in allergy and inflammatory responses

1998 • 398 citations

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

1997 • 380 citations

Platelet-derived growth factor in idiopathic pulmonary fibrosis.

1990 • 376 citations

Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling

2001 • 360 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β₁

1999 • 343 citations

Evidence of Fibroblast Heterogeneity and the Role of Fibroblast Subpopulations in Fibrosis

1994 • 343 citations

Lung Cytokine Production in Bleomycin-Induced Pulmonary Fibrosis

1992 • 321 citations

Macrophage inflammatory protein 1 modulates macrophage function.

1992 • 321 citations

Stimulation of Collagen and Glycosaminoglycan Production in Cultured Human Adult Dermal Fibroblasts by Recombinant Human Interleukin 6

1991 • 315 citations

Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis.

1997 • 309 citations

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia.

1994 • 309 citations

Interleukin‐1, Interleukin‐2, Interleukin‐4, Interleukin‐6, Tumor Necrosis Factor α, and Interferon‐γ Levels in Sera from Patients With Scleroderma

1992 • 303 citations

Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity.

1988 • 297 citations

A Transforming Growth Factor β (TGFβ) Control Element Drives TGFβ-induced Stimulation of Smooth Muscle α-Actin Gene Expression in Concert with Two CArG Elements

1997 • 297 citations

TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation.

1995 • 293 citations

Induction of natural killer cell migration by monocyte chemotactic protein−1, −2 and −3

1994 • 292 citations

Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice

1994 • 287 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Pulmonary fibrosis: cytokines in the balance

1998 • 272 citations

Cytokine Networks in the Regulation of Inflammation and Fibrosis in the Lung

1990 • 266 citations

Production of Interleukin 13 by Alveolar Macrophages from Normal and Fibrotic Lung

1998 • 266 citations

Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells.

1989 • 265 citations

A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets

1988 • 264 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.

1996 • 251 citations

Transforming growth factor‐α: Structure and biological activities

1986 • 250 citations

Activation of Collagen Gene Expression in Keloids: Co-Localization of Type I and VI Collagen and Transforming Growth Factor-β1 mRNA

1991 • 250 citations

Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.

1991 • 249 citations

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

1992 • 249 citations

Transforming growth factor-beta protein and mRNA in glomeruli in normal and diseased human kidneys.

1993 • 249 citations

Cyclooxygenase-2 Deficiency Results in a Loss of the Anti-Proliferative Response to Transforming Growth Factor-β in Human Fibrotic Lung Fibroblasts and Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

2001 • 248 citations

Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia.

1995 • 248 citations

Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells

1989 • 247 citations

Positive- and Negative-acting Krüppel-like Transcription Factors Bind a Transforming Growth Factor β Control Element Required for Expression of the Smooth Muscle Cell Differentiation Marker SM22α in Vivo

2000 • 244 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

Stimulation of Collagen Formation by Insulin and Insulin-Like Growth Factor I in Cultures of Human Lung Fibroblasts*

1989 • 229 citations

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.

1996 • 229 citations

Overexpression of tumor necrosis factor-α produces an increase in lung volumes and pulmonary hypertension

2001 • 221 citations

Collagen polymorphism in the lungAn immunochemical study of pulmonary fibrosis

1980 • 220 citations

Reversal of tumor-induced immunosuppression: a new approach to cancer therapy.

1997 • 219 citations

Interleukin-10 inhibits interleukin-8 production in human neutrophils

1994 • 213 citations

Quantitation of Collagen Types I and III during Wound Healing in Rat Skin

1979 • 212 citations

Transforming Growth Factor- β₁ Induces Phenotypic Modulation of Human Lung Fibroblasts to Myofibroblast Through a c-Jun-NH₂-Terminal Kinase-Dependent Pathway

2001 • 212 citations

α-Smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by γ-interferon

1992 • 209 citations

Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor

2000 • 206 citations

Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner

1988 • 205 citations

A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA)

1995 • 204 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth

1999 • 197 citations

A role for C-C chemokines in fibrotic lung disease

1995 • 196 citations

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

1986 • 194 citations

Developmental expression of the α receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation

1992 • 191 citations

Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody.

1995 • 190 citations

Role of Cytokines and Cytokine Therapy in Wound Healing and Fibrotic Diseases

2001 • 189 citations

Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.

1986 • 186 citations

CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair.

1997 • 183 citations

IL-1 alpha or tumor necrosis factor-alpha stimulate release of three NAP-1/IL-8-related neutrophil chemotactic proteins in human dermal fibroblasts.

1990 • 179 citations

Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.

1990 • 179 citations

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level

1999 • 177 citations

Immunohistologic Demonstration of Platelet-derived Growth Factor (PDGF) and sis-Oncogene Expression in Scleroderma

1989 • 173 citations

TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis.

1997 • 170 citations

Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis.

1995 • 167 citations

Structural comparison and chromosomal localization of the human and mouse IL-13 genes.

1993 • 167 citations

Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis.

1994 • 164 citations

Production and function of murine macrophage inflammatory protein-1 alpha in bleomycin-induced lung injury.

1994 • 161 citations

Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease.

1993 • 160 citations

Interleukin-4 and interferon-γ discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets

1996 • 156 citations

Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor.

1992 • 156 citations

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells

1996 • 154 citations

Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts

1991 • 154 citations

The Cellular Derivation and the Life Span of the Myofibroblast

1996 • 153 citations

IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils

1996 • 147 citations

GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism

2000 • 147 citations

TNF-α Receptor Knockout Mice Are Protected from the Fibroproliferative Effects of Inhaled Asbestos Fibers

1998 • 146 citations

Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122.

1991 • 145 citations

Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

1999 • 144 citations

Expression of transforming growth factor-alpha and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats.

1994 • 144 citations

Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 α and transforming growth factor-β1

1992 • 142 citations

Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.

1982 • 140 citations

IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase–dependent pathway

2001 • 137 citations

Immunohistochemical study of collagen types in human foetal lung and fibrotic lung disease.

1981 • 136 citations

IL-12 attenuates bleomycin-induced pulmonary fibrosis

2001 • 135 citations

Coordinate regulation of transforming growth factor beta gene expression and cell proliferation in hamster lungs undergoing bleomycin-induced pulmonary fibrosis.

1989 • 134 citations

Molecular mechanisms of TGF‐β antagonism by interferon γ and cyclosporine A in lung fibroblasts

2001 • 130 citations

Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo

2000 • 129 citations

Serum Level of Interleukin 8 Is Elevated in Idiopathic Pulmonary Fibrosis and Indicates Disease Activity

1998 • 128 citations

Rat lung fibroblast collagen metabolism in bleomycin-induced pulmonary fibrosis.

1985 • 126 citations

Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.

1993 • 126 citations

Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis.

1993 • 125 citations

Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung.

1995 • 125 citations

Attenuation of Lung Inflammation and Fibrosis in Interferon- γ –Deficient Mice after Intratracheal Bleomycin

2001 • 124 citations

Regulation of α-smooth muscle actin gene expression in myofibroblast differentiation from rat lung fibroblasts

2001 • 124 citations

Transforming growth factor beta 1 and interleukin 4 induced alpha smooth muscle actin expression and myofibroblast-like differentiation in human synovial fibroblasts in vitro: modulation by basic fibroblast growth factor

1997 • 119 citations

Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production.

1980 • 118 citations

JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.

1991 • 117 citations

Platelet-derived growth factor promotes human peripheral monocyte activation

1985 • 116 citations

TNF and IL-6 mediate MIP-1alpha expression in bleomycin-induced lung injury.

1998 • 116 citations

Differential stimulation of collagenase and chemotactic activity in fibroblasts derived from rat wound repair tissue and human skin by growth factors

1989 • 114 citations

Increased expression of type VI collagen in lung fibrosis.

1995 • 110 citations

Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.

1990 • 109 citations

Interferons and Collagen Production

1990 • 109 citations

Contractile Cells in Normal and Fibrotic Lung

1990 • 107 citations

Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice

2000 • 104 citations

Expression of the Integrin α8β1 during Pulmonary and Hepatic Fibrosis

2000 • 104 citations

Production of monocyte chemotactic and activating factor (MCAF) by human dermal fibroblasts in response to interleukin 1 or tumor necrosis factor

1989 • 103 citations

Tumor necrosis factor bifunctionally regulates matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP) production by human fibroblasts

1990 • 103 citations

Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, Interleukin‐1β and TNF‐α

2000 • 102 citations

Effect of γ-Interferon on Collagen Synthesis by Normal and Fibrotic Human Lung Fibroblasts

1992 • 102 citations

Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.

1988 • 102 citations

Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta.

1997 • 102 citations

TNF-α, PDGF, and TGF-β1 Expression by Primary Mouse Bronchiolar-Alveolar Epithelial and Mesenchymal Cells: TNF-α Induces TGF-β1

2001 • 100 citations

Lymphokine regulation of inflammatory processes: Interleukin-4 stimulates fibroblast proliferation

1988 • 98 citations

Concentration, biosynthesis and degradation of collagen in idiopathic pulmonary fibrosis.

1986 • 98 citations

Stimulation of rat endothelial cell transforming growth factor-beta production by bleomycin.

1991 • 98 citations

Increased Expression of Platelet-Derived Growth Factor A and Insulin-Like Growth Factor-I in BAL Cells During the Development of Bleomycin-Induced Pulmonary Fibrosis in Mice

1996 • 97 citations

Interleukin-9 Reduces Lung Fibrosis and Type 2 Immune Polarization Induced by Silica Particles in a Murine Model

2001 • 95 citations

Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells

1998 • 95 citations

Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family.

1988 • 93 citations

Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis

1992 • 91 citations

The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury.

1996 • 90 citations

Commentary Signal transduction by the receptors for platelet-derived growth factor

1990 • 87 citations

Effect of endothelin-1 on α-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases

1999 • 87 citations

Presence of Platelet-derived Growth Factor in Normal and Fibrotic Lung Is Specifically Associated with Interstitial Macrophages, While Both Interstitial Macrophages and Alveolar Epithelial Cells Express the c-sis Proto-oncogene

1991 • 87 citations

Cytokines modulate the sensitivity of human fibroblasts to stimulation with insulin-like growth factor-I (IGF-I) by altering endogenous IGF-binding protein production

1993 • 87 citations

Immunolocalization of Transforming Growth Factor-α, Epidermal Growth Factor (EGF), and EGF-Receptor in Normal and Injured Developing Human Lung

1995 • 86 citations

The Insulin-like Growth Factors and the Lung

1990 • 85 citations

Bleomycin Regulation of Transforming Growth Factor-β mRNA in Rat Lung Fibroblasts

1992 • 84 citations

Transforming Growth Factor- α Deficiency Reduces Pulmonary Fibrosis in Transgenic Mice

1999 • 82 citations

TGF-beta receptor expression and smad2 localization are cell density dependent in fibroblasts.

2000 • 82 citations

Increased expression of the interleukin-10 gene by alveolar macrophages in interstitial lung disease

1997 • 81 citations

Morphometric Analysis of Insulin-like Growth Factor-I Localization in Lung Tissues of Patients with Idiopathic Pulmonary Fibrosis

1998 • 81 citations

Immunoreactive interleukin 4 and interferon-? expression by type II alveolar epithelial cells in interstitial lung disease

1999 • 80 citations

LUNG INTERLEUKIN-4 GENE EXPRESSION IN A MURINE MODEL OF BLEOMYCIN-INDUCED PULMONARY FIBROSIS

2001 • 79 citations

Role of lymphotoxin in expression of interleukin 6 in human fibroblasts. Stimulation and regulation.

1990 • 78 citations

Bleomycin-induced synthesis of type I procollagen by human lung and skin fibroblasts in culture

1980 • 78 citations

A Possible Role for Transforming Growth Factor-β in Systemic Sclerosis

1990 • 76 citations

Induction of Telomerase Activity in Fibroblasts from Bleomycin-Injured Lungs

2000 • 73 citations

Transforming Growth Factor- β₁Overexpression in Tumor Necrosis Factor- α Receptor Knockout Mice Induces Fibroproliferative Lung Disease

2001 • 73 citations

Expression of Smads during in Vitro Transdifferentiation of Hepatic Stellate Cells to Myofibroblasts

2001 • 72 citations

The Deletion of Transforming Growth Factor-β-Induced Myofibroblasts Depends on Growth Conditions and Actin Organization

1999 • 72 citations

α-Smooth muscle actin is expressed in a subset of bone marrow stromal cells in normal and pathological conditions

1989 • 72 citations

Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis.

1999 • 70 citations

The role of IL-5 in bleomycin-induced pulmonary fibrosis

1998 • 69 citations

Lung Fibrosis Induced by Silica Particles in NMRI Mice Is Associated with an Upregulation of the p40 Subunit of Interleukin-12 and Th-2 Manifestations

1999 • 68 citations

Lung interleukin-5 expression in murine bleomycin-induced pulmonary fibrosis.

1997 • 68 citations

Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells.

1993 • 64 citations

Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors

1991 • 63 citations

Effective Treatment of the Pulmonary Fibrosis Elicited in Mice by Bleomycin or Silica with Anti-CD-11 Antibodies

1993 • 63 citations

Expression and Localization of Epidermal Growth Factor, Transforming Growth Factor-α, and Localization of Their Common Receptor in Fetal Human Lung Development

1996 • 63 citations

Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma.

1992 • 61 citations

Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins

2001 • 60 citations

Organisation of experimental thrombosis by blood cells

1985 • 60 citations

Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor

1990 • 60 citations

Myofibroblasts in diffuse alveolar damage of the lung.

1998 • 59 citations

Regulation of Telomerase Activity in Rat Lung Fibroblasts

2002 • 58 citations

Variable Expression of Platelet-derived Growth Factor Family Proteins in Acute Lung Injury

1993 • 57 citations

Human T cell lines and clones respond to IL-9.

1993 • 57 citations

In situ hybridization analysis of rat lung alpha 1(I) and alpha 2(I) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection.

1994 • 55 citations

Increased TGF-beta1 in the lungs of asbestos-exposed rats and mice: reduced expression in TNF-alpha receptor knockout mice.

2001 • 54 citations

Production and Action of Insulin-like Growth Factor I/Somatomedin C in Primary Cultures of Fetal Lung Fibroblasts

1989 • 54 citations

CCR2: From Cloning to the Creation of Knockout Mice

1999 • 53 citations

Soluble Transforming Growth Factor-α Is Present in the Pulmonary Edema Fluid of Patients With Acute Lung Injury

1997 • 53 citations

Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis

2000 • 52 citations

Interferon‐γ inhibits the myofibroblastic phenotype of rat palatal fibroblasts induced by transforming growth factor‐β1 in vitro

1999 • 52 citations

Control of Il-6 Expression and Response in Fibroblasts from Patients with Systemic Sclerosis

1994 • 52 citations

Activin receptors are expressed on human lung fibroblast and activin a facilitates fibroblast-mediated collagen gel contraction

2000 • 52 citations

Bleomycin-induced pulmonary fibrosis is independent of eosinophils

2000 • 51 citations

Effect of epidermal growth factor/urogastrone on glycosaminoglycan synthesis and accumulation in vitro in the developing mouse palate

1985 • 50 citations

Differences In Vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks

1977 • 48 citations

Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12

2001 • 47 citations

Epidermal growth factor stimulates type-V collagen synthesis in cultured murine palatal shelves

1984 • 47 citations

Evolving principles in immunopathology: interleukin 10 and its relationship to Epstein-Barr virus protein BCRF1

1991 • 47 citations

Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures.

1991 • 46 citations

Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.

1993 • 46 citations

Role of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Fibrosis Induced in Mice by Bleomycin

1993 • 45 citations

Auto-induction of Transforming Growth Factor-β in Human Lung Fibroblasts

1993 • 45 citations

Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins

1990 • 44 citations

Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms.

1996 • 43 citations

Vitronectin in Bronchoalveolar Lavage Fluid Is Increased in Patients with Interstitial Lung Disease

1991 • 43 citations

Differential mRNA Expression of Insulin-like Growth Factor-1 Splice Variants in Patients With Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis

2001 • 42 citations

The potential role of PDGF, IGF-1, TGF-beta expression in idiopathic pulmonary fibrosis.

2000 • 41 citations

Decreased expression of AMPA receptor messenger RNA and protein in AIDS: A model for HIV-associated neurotoxicity

1995 • 39 citations

ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN B CELL LINE FROM THE LUNG TISSUE OF A PATIENT WITH SCLERODERMA; EXTRAORDINARY HIGH LEVEL OF IL-6 SECRETION BY STIMULATED FIBROBLASTS

2001 • 39 citations

Chemotactic factors stimulate CD18-dependent canine neutrophil adherence and motility on lung fibroblasts.

1996 • 38 citations

Bleomycin treatment of chick fibroblasts causes an increase of polysomal type I procollagen mRNAs. Reversal of the bleomycin effect by dexamethasone.

1983 • 37 citations

Subpopulations of rat lung fibroblasts with different amounts of type I and type III collagen mRNAs.

1990 • 37 citations

Closing in on the signals of hepatic fibrosis

1997 • 37 citations

Normal Human Lung Fibroblasts Differently Modulate Interleukin-10 and Interleukin-12 Production by Monocytes

2001 • 37 citations

Partial purification of a mast cell growth-enhancing activity and its separation from IL-3 and IL-4.

1989 • 37 citations

Granulocyte and macrophage colony-stimulating factors stimulate proliferation of human keratinocytes

1997 • 36 citations

Synthesis of PGE2, Collagenase and Tissue Factor by Fibroblast Substrains: Substrains are Differentially Activated for Different Metabolic Products

1985 • 34 citations

Morphological and Biochemical Properties of Alveolar Fibroblasts in Interstitial Lung Diseases

2001 • 34 citations

Soluble Tumor Necrosis Factor (TNF) Receptors p55 and p75 and Interleukin-10 Downregulate TNF- α Activity during the Lung Response to Silica Particles in NMRI Mice

1999 • 34 citations

Chemotactic Cytokines Mediate Leukocyte Recruitment in Fibrotic Lung Disease

1996 • 32 citations

Tumor Necrosis Factor α Induces Invasiveness of Human Skin Fibroblasts In Vitro

1990 • 29 citations

Molecular and Developmental Biology Aspects of Fibroblast Growth Factor

1988 • 23 citations

Enhanced Production of IL-1 Receptor Antagonist by Alveolar Macrophages from Patients with Interstitial Lung Disease

1993 • 23 citations

Effect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activity

2000 • 23 citations

Bronchial Epithelial Cell Matrix Production in Response to Silica and Basic Fibroblast Growth Factor

2001 • 22 citations

The role of soluble factors in bleomycin-induced pulmonary fibrosis.

1982 • 22 citations

IL-9 and Lung Fibrosis

2001 • 19 citations

Regulation of Rat Pulmonary Endothelial Cell Interleukin-6 Production by Bleomycin: Effects of Cellular Fatty Acid Composition

1993 • 18 citations

Expression of TGF-beta 1, PDGF and IGF-1 mRNA in lung of bleomycin-A5-induced pulmonary fibrosis in rats.

1996 • 16 citations

Regulation of PDGFR-α in rat pulmonary myofibroblasts by staurosporine

2001 • 15 citations

Keratinocyte Growth Stimulation by Granulocyte-macrophage Colony-stimulating Factor (GM-CSF).

1997 • 12 citations

Fibroblasts as Target and Effector Cells in Japanese Patients with Sarcoidosis

1998 • 8 citations

Basic Fibroblast Growth Factor in Fibrosing Alveolitis Induced by Oxygen Stress

1996 • 8 citations

Nitrite production in mouse 3T3 fibroblasts by bleomycin-stimulated peripheral blood mononuclear cell factors.

1999 • 5 citations

Platelet-Derived Growth Factor Receptors Are Essential in the Development of Asbestos-Induced Fibrosis

2001 • 3 citations

Effect of Perfusion and Preservation on IL1-β, IL-6, and IL-10 Production in Murine Lung

2001 • 2 citations