Interleukin 6 Is Required for the Development of Collagen-induced Arthritis

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Rheumatoid Arthritis

1996 • 960 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1996 • 538 citations

Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.

1997 • 519 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

2008 • 514 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

1991 • 364 citations

Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice.

1996 • 346 citations

Type II Collagen Autoimmunity in Animals and Provocations Leading to Arthritis

1990 • 304 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis.

1994 • 237 citations

Collagen-induced Arthritis Is Reduced in 5-Lipoxygenase-activating Protein-deficient Mice

1997 • 221 citations

A genome scan localizes five non–MHC loci controlling collagen–induced arthritis in rats

1996 • 212 citations

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.

1985 • 210 citations

The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in mice

1993 • 204 citations

Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice.

1996 • 203 citations

INTERLEUKIN-6 (IL-6) INDUCES THE PROLIFERATION OF SYNOVIAL FIBROBLASTIC CELLS IN THE PRESENCE OF SOLUBLE IL-6 RECEPTOR

1995 • 202 citations

Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines.

1988 • 183 citations

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

1996 • 180 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice

1995 • 144 citations

Reduced Incidence and Severity of Antigen-induced Autoimmune Diseases in Mice Lacking Interferon Regulatory Factor-1

1997 • 131 citations

Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.

1996 • 124 citations

Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.

1990 • 121 citations

Measurement of whole body interleukin-6 (IL-6) production: prediction of the efficacy of anti-IL-6 treatments

1995 • 117 citations

Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice.

1997 • 114 citations

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

1995 • 108 citations

Serum soluble interleukin‐6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin‐6 signal

1993 • 106 citations

Protective effect of anti‐interleukin (IL)‐6 antibody against endotoxin, associated with paradoxically increased IL‐6 levels

1992 • 105 citations

Limited involvement of interleukin‐6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin‐6 or its receptor in various murine models

1992 • 83 citations

Genes on the X chromosome affect development of collagen-induced arthritis in mice

1993 • 83 citations

Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis.

1992 • 68 citations

Suppression of fever and the acute-phase response in a patient with juvenile chronic arthritis treated with monoclonal antibody to tumour necrosis factor-alpha (cA2)

1997 • 61 citations

Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1.

1996 • 59 citations

IL-6 is an in vitro and in vivo autocrine growth factor for middle T antigen-transformed endothelial cells.

1996 • 52 citations

The effect of recombinant human interleukin 1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit.

1994 • 52 citations

Experimental autoimmune arthritis in mice

1988 • 28 citations

Intravenous immunoglobulin therapy for rheumatic diseases

1994 • 24 citations

T cell regulation of collagen‐induced arthritis in mice. II. Immunomodulation of arthritis by cytotoxic T cell hybridomas specific for type II collagen

1993 • 19 citations

Transcriptional regulation of acute phase genes by IL-6 and related cytokines.

1994 • 12 citations

Interleukin-6-blocking agents

1997 • 1 citations