Endocytosis, Endosome Trafficking, and the Regulation ofDrosophilaDevelopment

Rab proteins as membrane organizers

2001 • 3,320 citations

Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes

2003 • 1,999 citations

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

2003 • 1,102 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

2005 • 852 citations

Signal transduction and endocytosis: close encounters of many kinds

2002 • 820 citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

2003 • 794 citations

Communicating with Hedgehogs

2005 • 787 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta

2003 • 773 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

Lipoprotein particles are required for Hedgehog and Wingless signalling

2005 • 678 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1998 • 642 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Phosphoinositide Recognition Domains

2003 • 556 citations

Not just a sink: endosomes in control of signal transduction

2004 • 517 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Protein sorting into multivesicular endosomes

2003 • 496 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

Guidance of Cell Migration by the Drosophila PDGF/VEGF Receptor

2001 • 465 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Morphogens, their identification and regulation

2004 • 437 citations

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

2001 • 433 citations

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

2002 • 431 citations

Argosomes

2001 • 413 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

The dishevelled protein is modified by wingless signaling in Drosophila.

1995 • 389 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

2002 • 355 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

The EGF receptor: a nexus for trafficking and signaling

2000 • 346 citations

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

2002 • 338 citations

The roles of receptor and ligand endocytosis in regulating Notch signaling

2005 • 335 citations

Negative receptor signalling

2003 • 333 citations

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

2001 • 333 citations

Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing

1998 • 331 citations

Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

2003 • 308 citations

Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System

2005 • 306 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

2000 • 291 citations

The sterol-sensing domain: multiple families, a unique role?

2002 • 286 citations

A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling

2003 • 282 citations

Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo

2005 • 271 citations

Regulation of Receptor Tyrosine Kinase Signaling by Endocytic Trafficking

2001 • 269 citations

Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis

1997 • 265 citations

neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis

2001 • 258 citations

Guidance of Cell Migration by EGF Receptor Signaling During Drosophila Oogenesis

2001 • 254 citations

Unrestricted Synaptic Growth in spinster—a Late Endosomal Protein Implicated in TGF-β-Mediated Synaptic Growth Regulation

2002 • 253 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

DrosophilaEpsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch

2004 • 246 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

Unequal Segregation of Neuralized Biases Notch Activation during Asymmetric Cell Division

2003 • 236 citations

When cell biology meets development: endocytic regulation of signaling pathways

2002 • 230 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Regulators of Endocytosis Maintain Localized Receptor Tyrosine Kinase Signaling in Guided Migration

2005 • 219 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

ENTH/ANTH proteins and clathrin-mediated membrane budding

2003 • 207 citations

Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin

1999 • 200 citations

Sec15, a Component of the Exocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Organ Precursors

2005 • 200 citations

Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS

1998 • 199 citations

Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation

2004 • 195 citations

DrosophilaDeltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

2004 • 193 citations

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

2001 • 191 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

Regulation of Notch Endosomal Sorting and Signaling by Drosophila Nedd4 Family Proteins

2004 • 188 citations

Altered localization ofDrosophilaSmoothened protein activates Hedgehog signal transduction

2003 • 186 citations

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells

2004 • 186 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila

2003 • 181 citations

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate

2001 • 180 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Formation of the BMP Activity Gradient in the Drosophila Embryo

2005 • 178 citations

The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis

2000 • 176 citations

Ubiquitin and endocytic internalization in yeast and animal cells

2004 • 176 citations

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling inDrosophila

2005 • 170 citations

Mechanisms controlling EGF receptor endocytosis and degradation

2003 • 169 citations

Shaping Morphogen Gradients

2001 • 169 citations

Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila

2005 • 168 citations

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

2004 • 165 citations

Numb Inhibits Membrane Localization of Sanpodo, a Four-Pass Transmembrane Protein, to Promote Asymmetric Divisions in Drosophila

2003 • 161 citations

The ubiquitin ligaseDrosophilaMind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

2005 • 156 citations

The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase

1999 • 154 citations

Mutations in the Drosophila hook gene inhibit endocytosis of the boss transmembrane ligand into multivesicular bodies.

1996 • 153 citations

The dynamics of the cycle

2005 • 151 citations

Signal dispersal and transduction through the endocytic pathway

2003 • 144 citations

Hrs mediates downregulation of multiple signalling receptors in Drosophila

2003 • 143 citations

Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development

1995 • 135 citations

Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo

1999 • 133 citations

Numb and α‐Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

2005 • 127 citations

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

1999 • 122 citations

Rab23, a Negative Regulator of Hedgehog Signaling, Localizes to the Plasma Membrane and the Endocytic Pathway

2003 • 118 citations

Incredible journey: how do developmental signals travel through tissue?

2004 • 115 citations

Formation of morphogen gradients in the Drosophila wing

1999 • 115 citations

The interplay between DSL proteins and ubiquitin ligases in Notch signaling

2005 • 113 citations

A Mutational Analysis of dishevelled in Drosophila Defines Novel Domains in the Dishevelled Protein as Well as Novel Suppressing Alleles of axin

2002 • 112 citations

Lethal Giant Larvae Controls the Localization of Notch-Signaling Regulators Numb, Neuralized, and Sanpodo in Drosophila Sensory-Organ Precursor Cells

2005 • 111 citations

Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface.

1995 • 109 citations

Creation of a Sog Morphogen Gradient in the Drosophila Embryo

2002 • 108 citations

Dpp gradient formation by dynamin-dependent endocytosis: receptor trafficking and the diffusion model

2004 • 104 citations

Elucidating mechanisms underlying robustness of morphogen gradients

2004 • 101 citations

Regulating morphogen gradients in the Drosophila wing

2002 • 97 citations

PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster

2002 • 94 citations

The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein

1998 • 93 citations

Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation

2005 • 91 citations

The ins and outs of Wingless signaling

2003 • 90 citations

Morphogen Gradient Formation and Vesicular Trafficking

2002 • 88 citations

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

2004 • 87 citations

Morphogen Transport along Epithelia, an Integrated Trafficking Problem

2002 • 82 citations

The Hrs/STAM Complex in the Downregulation of Receptor Tyrosine Kinases

2005 • 81 citations

Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless inDrosophilaimaginal discs

2005 • 76 citations

The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila

2004 • 74 citations

Genetic Characterization of the Drosophila melanogaster Suppressor of deltex Gene: A Regulator of Notch Signaling

1998 • 73 citations

Either Part of a Drosophila Epsin Protein, Divided after the ENTH Domain, Functions in Endocytosis of Delta in the Developing Eye

2003 • 70 citations

Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment

2004 • 61 citations

Control of EGF receptor signalling: lessons from fruitflies.

1999 • 60 citations

Endocytosis: Signaling from Endocytic Membranes to the Nucleus

2004 • 59 citations

Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos

2003 • 56 citations

Functions and mechanisms of receptor tyrosine kinase Torso signaling: Lessons from Drosophila embryonic terminal development

2005 • 55 citations

Modulation of developmental signals by endocytosis: different means and many ends

2003 • 54 citations

Down-regulation of notch target gene expression by suppressor of deltex

2003 • 43 citations

Genes that drive invasion and migration in Drosophila

2003 • 42 citations

Regulation of Membrane Localization of Sanpodo bylethal giant larvaeandneuralizedin Asymmetrically Dividing Cells ofDrosophilaSensory Organs

2005 • 42 citations

The Kinesin-related Protein Costal2 Associates with Membranes in a Hedgehog-sensitive, Smoothened-independent Manner

2004 • 38 citations

Endocytic trafficking during Drosophila development

2003 • 37 citations

Roles of receptor tyrosine kinases in Drosophila development

1992 • 37 citations

Distinct Consequences of Sterol Sensor Mutations in Drosophila and Mouse patched Homologs

2002 • 33 citations

Membrane traffic during embryonic development: epithelial formation, cell fate decisions and differentiation

2004 • 22 citations

Spinsters, Synaptic Defects, and Amaurotic Idiocy

2002 • 11 citations

A Screen for Genes Regulating the Wingless Gradient in Drosophila Embryos

2005 • 7 citations