Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

RING Finger Proteins

2000 • 1,216 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

1996 • 879 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

P-element-mediated enhancer detection: a versatile method to study development in Drosophila.

1989 • 679 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

1998 • 617 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2000 • 492 citations

Sprouty, an Intracellular Inhibitor of Ras Signaling

1999 • 462 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.

1995 • 400 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

GFP and β-Galactosidase Transformation Vectors for Promoter/Enhancer Analysis in Drosophila

2000 • 344 citations

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

1996 • 331 citations

A New Ticket for Entry into Budding Vesicles—Ubiquitin

2001 • 321 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

1994 • 306 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Requirement for Dynamin during Notch Signaling inDrosophilaNeurogenesis

1997 • 265 citations

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1992 • 248 citations

A role for the Drosophila neurogenic genes in mesoderm differentiation

1991 • 235 citations

PHYL Acts to Down-Regulate TTK88, a Transcriptional Repressor of Neuronal Cell Fates, by a SINA-Dependent Mechanism

1997 • 233 citations

Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling

2001 • 225 citations

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

1993 • 222 citations

Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

1997 • 221 citations

Photoreceptor Cell Differentiation Requires Regulated Proteolysis of the Transcriptional Repressor Tramtrack

1997 • 219 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.

1994 • 195 citations

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

1997 • 189 citations

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila

1998 • 177 citations

The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination

2000 • 171 citations

The intracellular deletions of DELTA and SERRATE define dominant negative forms of the Drosophila Notch ligands

1996 • 149 citations

Altered Epidermal Growth Factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions

1993 • 147 citations

Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway

1995 • 139 citations

Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development

1995 • 135 citations

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.

1992 • 133 citations

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.

1991 • 112 citations

Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment

1998 • 103 citations

A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development

1998 • 100 citations

shibire, a neurogenic mutant of Drosophila

1990 • 91 citations

neuralized Functions Cell-Autonomously to Regulate a Subset of Notch-Dependent Processes during Adult Drosophila Development

2001 • 87 citations

Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification

1995 • 85 citations

Neuralized functions cell autonomously to regulate Drosophila sense organ development

2000 • 84 citations

Dominant-negative mutation in the β2 and β6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage

1999 • 81 citations

Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region

1998 • 70 citations

Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit.

1993 • 64 citations

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized

2001 • 57 citations

neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development

2001 • 57 citations

The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose

1998 • 48 citations

The Drosophila neuralized gene encodes a C3HC4 zinc finger.

1993 • 41 citations