The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

Functional rafts in cell membranes

1997 • 9,471 citations

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

1997 • 1,440 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

1998 • 839 citations

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1997 • 797 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1999 • 628 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Morphogens, Compartments, and Pattern: Lessons from Drosophila?

1996 • 559 citations

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

1999 • 527 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Transducing Hedgehog: the story so far

1998 • 444 citations

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

1999 • 375 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

1998 • 303 citations

Hedgehog and Patched in Neural Development and Disease

1998 • 259 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing

1999 • 164 citations

Hedgehog activity, independent of Decapentaplegic, participates in wing disc patterning

1997 • 155 citations

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 • 141 citations

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

1994 • 111 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport

2000 • 98 citations

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

1996 • 61 citations

A Gain-of-Function Mutant of patched Dissects Different Responses to the Hedgehog Gradient

2000 • 37 citations

Recurrent G-to-A substitution in a single condon of SREBP celavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

1996 • 21 citations