Negative receptor signalling

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

RING Finger Proteins

2000 • 1,216 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

1999 • 825 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Cbl: many adaptations to regulate protein tyrosine kinases

2001 • 621 citations

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

2001 • 589 citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 • 584 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

2002 • 539 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed

1999 • 503 citations

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

2001 • 501 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Sprouty, an Intracellular Inhibitor of Ras Signaling

1999 • 462 citations

A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

2001 • 438 citations

Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum

2002 • 437 citations

Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein

2001 • 430 citations

Spred is a Sprouty-related suppressor of Ras signalling

2001 • 429 citations

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

2002 • 409 citations

Ubiquitin Enters the New Millennium

2001 • 390 citations

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

2002 • 378 citations

The lipid phosphatase SHIP2 controls insulin sensitivity

2001 • 369 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

2002 • 280 citations

Sprouty is a general inhibitor of receptor tyrosine kinase signaling

1999 • 261 citations

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

2002 • 231 citations

Sprouty2 Inhibits the Ras/MAP Kinase Pathway by Inhibiting the Activation of Raf

2002 • 224 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

2001 • 200 citations

CIN85/CMS family of adaptor molecules

2002 • 196 citations

Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation

2001 • 182 citations

Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking

2001 • 179 citations

Phosphatidylinositol 4,5-Bisphosphate Phosphatase Regulates the Rearrangement of Actin Filaments

1997 • 165 citations

Inhibition of Angiogenesis by a Mouse Sprouty Protein

2001 • 156 citations

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

2002 • 155 citations

Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4

2002 • 144 citations

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

2002 • 137 citations

CIN85 Participates in Cbl-b-mediated Down-regulation of Receptor Tyrosine Kinases

2002 • 137 citations

Evidence for Direct Interaction between Sprouty and Cbl

2001 • 127 citations

The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission

2001 • 127 citations

The Tyrosine Kinase ACK1 Associates with Clathrin-coated Vesicles through a Binding Motif Shared by Arrestin and Other Adaptors

2001 • 126 citations

ARK-1 Inhibits EGFR Signaling in C. elegans

2000 • 104 citations

The C Terminus of Sprouty Is Important for Modulation of Cellular Migration and Proliferation

2001 • 103 citations

The Cysteine-Rich Sprouty Translocation Domain Targets Mitogen-Activated Protein Kinase Inhibitory Proteins to Phosphatidylinositol 4,5-Bisphosphate in Plasma Membranes

2002 • 80 citations

Drosophila Ack Targets Its Substrate, the Sorting Nexin DSH3PX1, to a Protein Complex Involved in Axonal Guidance

2002 • 56 citations

ARK-1 Inhibits EGFR Signaling in C. elegans

2000 • 17 citations