Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Lipid rafts and signal transduction

2000 • 6,079 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

2002 • 2,231 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

2001 • 1,236 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

2002 • 987 citations

Caveolae: From Cell Biology to Animal Physiology

2002 • 977 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Ras proteins: different signals from different locations

2003 • 843 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

2003 • 794 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections

2002 • 788 citations

Regulated internalization of caveolae.

1994 • 760 citations

Caveolae/raft-dependent endocytosis

2003 • 722 citations

Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae

2002 • 715 citations

The biogenesis of multivesicular endosomes

2004 • 694 citations

Lipid rafts: heterogeneity on the high seas

2004 • 689 citations

GPI-Anchored Proteins Are Delivered to Recycling Endosomes via a Distinct cdc42-Regulated, Clathrin-Independent Pinocytic Pathway

2002 • 647 citations

Resistance of cell membranes to different detergents

2003 • 647 citations

Caveolin-1 Regulates Transforming Growth Factor (TGF)-β/SMAD Signaling through an Interaction with the TGF-β Type I Receptor

2001 • 638 citations

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

2003 • 631 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands

2003 • 597 citations

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 • 597 citations

Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms

2003 • 589 citations

Membrane microdomains and caveolae

1999 • 580 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

Phosphoinositide Recognition Domains

2003 • 556 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

2004 • 536 citations

Clathrin

2000 • 528 citations

Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

2001 • 525 citations

Caveolin-Stabilized Membrane Domains as Multifunctional Transport and Sorting Devices in Endocytic Membrane Traffic

2004 • 517 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Interleukin 2 Receptors and Detergent-Resistant Membrane Domains Define a Clathrin-Independent Endocytic Pathway

2001 • 513 citations

The role of phosphoinositides in membrane transport

2001 • 482 citations

Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane

1996 • 449 citations

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

2003 • 448 citations

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

2003 • 445 citations

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation

2003 • 441 citations

Sorting GPI-anchored proteins

2004 • 415 citations

Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor

1990 • 415 citations

Coat proteins: shaping membrane transport

2003 • 410 citations

Caveosomes and endocytosis of lipid rafts

2003 • 386 citations

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

2004 • 382 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

2002 • 375 citations

Hrs recruits clathrin to early endosomes

2001 • 374 citations

Molecular Dynamics and Interactions for Creation of Stimulation‐Induced Stabilized Rafts from Small Unstable Steady‐State Rafts

2004 • 368 citations

Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma.

1994 • 356 citations

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains

1996 • 354 citations

Lipid rafts and B-cell activation

2002 • 349 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

The EGF receptor: a nexus for trafficking and signaling

2000 • 346 citations

Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.

2000 • 345 citations

NGF Signaling from Clathrin-Coated Vesicles

2001 • 340 citations

TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

2002 • 330 citations

Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila Raft Lipid Microdomains

1999 • 320 citations

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

2003 • 316 citations

Regulated Migration of Epidermal Growth Factor Receptor from Caveolae

1999 • 314 citations

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

2000 • 307 citations

STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes

2003 • 306 citations

Cytoplasmic PML function in TGF-β signalling

2004 • 303 citations

TGFβ receptor internalization into EEA1-enriched early endosomes

2002 • 298 citations

Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

2002 • 296 citations

Endosomal Signaling of Epidermal Growth Factor Receptor Stimulates Signal Transduction Pathways Leading to Cell Survival

2002 • 289 citations

Selective Stimulation of Caveolar Endocytosis by Glycosphingolipids and Cholesterol

2004 • 265 citations

A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex

2002 • 259 citations

Subcellular targeting by membrane lipids

2001 • 259 citations

Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction

1995 • 241 citations

ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling

2003 • 241 citations

Caveolin-1 Is a Negative Regulator of Caveolae-mediated Endocytosis to the Endoplasmic Reticulum

2002 • 235 citations

CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1

2003 • 216 citations

Signaling on the Endocytic Pathway

2001 • 215 citations

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant μ2 subunit and its effects on endocytosis

1999 • 212 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

ENTH/ANTH proteins and clathrin-mediated membrane budding

2003 • 207 citations

Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains.

1995 • 206 citations

Ligand-dependent and -independent Transforming Growth Factor-β Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11

2004 • 206 citations

The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors

1998 • 205 citations

Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

2003 • 202 citations

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

2001 • 200 citations

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

2000 • 195 citations

Cytokine Signaling

2002 • 190 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

Lipid rafts and plasma membrane microorganization: insights from Ras

2004 • 187 citations

Altered localization ofDrosophilaSmoothened protein activates Hedgehog signal transduction

2003 • 186 citations

Sequestration of Epidermal Growth Factor Receptors in Non-caveolar Lipid Rafts Inhibits Ligand Binding

2002 • 181 citations

Threonine Phosphorylation Diverts Internalized Epidermal Growth Factor Receptors from a Degradative Pathway to the Recycling Endosome

2000 • 179 citations

Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

2000 • 176 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

Insulin Signaling in Microdomains of the Plasma Membrane

2003 • 171 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

The arguments for pre-existing early and late endosomes

1991 • 156 citations

Internalized Epidermal Growth Factor Receptors Participate in the Activation of p21 in Fibroblasts

1999 • 151 citations

The sorbin homology domain: A motif for the targeting of proteins to lipid rafts

2001 • 151 citations

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF‐β/Smad signalling

2002 • 150 citations

Caveolae — from ultrastructure to molecular mechanisms

2003 • 148 citations

Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

2000 • 147 citations

Early Endosomal Regulation of Smad-dependent Signaling in Endothelial Cells

2002 • 143 citations

GM1-Containing Lipid Rafts Are Depleted within Clathrin-Coated Pits

2003 • 142 citations

The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane

2001 • 139 citations

H-Ras Signaling and K-Ras Signaling Are Differentially Dependent on Endocytosis

2002 • 137 citations

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

2000 • 135 citations

PI 3-Kinases and PTEN

2002 • 134 citations

Endocytosis and mitogenic signaling

1999 • 131 citations

Transforming Growth Factor-β Receptors Interact with AP2 by Direct Binding to β2 Subunit

2002 • 127 citations

N-Terminal Protein Acylation Confers Localization to Cholesterol, Sphingolipid-enriched Membranes But Not to Lipid Rafts/Caveolae

2001 • 123 citations

Second Cysteine-rich Region of Epidermal Growth Factor Receptor Contains Targeting Information for Caveolae/Rafts

2002 • 120 citations

Localization of Autocrine Motility Factor Receptor to Caveolae and Clathrin-independent Internalization of Its Ligand to Smooth Endoplasmic Reticulum

1998 • 119 citations

Mechanism of the spatio-temporal regulation of Ras and Rap1

2003 • 111 citations

Stimulation of Cell Proliferation by Endosomal Epidermal Growth Factor Receptor As Revealed through Two Distinct Phases of Signaling

2003 • 103 citations

Epidermal growth factor pathway substrate 15, Eps15

1999 • 98 citations

Clathrin Adaptors Really Adapt

2002 • 94 citations

A single internalization signal from the di-leucine family is critical for constitutive endocytosis of the type II TGF-β receptor

2001 • 94 citations

Transforming Growth Factor β Activates Smad2 in the Absence of Receptor Endocytosis

2002 • 90 citations

Distribution and Transport of Cholesterol-rich Membrane Domains Monitored by a Membrane-impermeant Fluorescent Polyethylene Glycol-derivatized Cholesterol

2004 • 90 citations

Annexin II Is Required for Apical Transport in Polarized Epithelial Cells

2004 • 83 citations

Intersectin Activates Ras but Stimulates Transcription through an Independent Pathway Involving JNK

2003 • 63 citations

Differential Requirement for Type I and Type II Transforming Growth Factor β Receptor Kinase Activity in Ligand-mediated Receptor Endocytosis

1998 • 55 citations

Transforming Growth Factor β Receptor Signaling and Endocytosis Are Linked through a COOH Terminal Activation Motif in the Type I Receptor

2001 • 48 citations

Dynamics of Endosomal Sorting

2003 • 45 citations

Phosphorylation of Hrs downstream of the epidermal growth factor receptor

2002 • 39 citations

Down-regulation of Transforming Growth Factor-β Receptors: Cooperativity between the Types I, II, and III Receptors and Modulation at the Cell Surface

1999 • 32 citations