Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Wnt signaling and cancer

2000 • 3,215 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

2002 • 1,942 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

LDL-receptor-related proteins in Wnt signal transduction

2000 • 1,305 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

2000 • 1,143 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

An LDL-receptor-related protein mediates Wnt signalling in mice

2000 • 1,080 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Induction, assembly, maturation and maintenance of a postsynaptic apparatus

2001 • 1,003 citations

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

2000 • 992 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 • 870 citations

β-catenin signaling and cancer

1999 • 867 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

2001 • 826 citations

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

2001 • 807 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

2001 • 763 citations

Dishevelled controls cell polarity during Xenopus gastrulation

2000 • 750 citations

An adaptive coding model of neural function in prefrontal cortex

2001 • 744 citations

Flamingo, a Seven-Pass Transmembrane Cadherin, Regulates Planar Cell Polarity under the Control of Frizzled

1999 • 703 citations

Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

2002 • 698 citations

PDZ Domains: Structural Modules for Protein Complex Assembly

2002 • 696 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 671 citations

Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

1998 • 642 citations

The role of RhoA in tissue polarity and Frizzled signalling

1997 • 558 citations

Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton

2001 • 546 citations

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

2001 • 516 citations

Mechanisms of convergence and extension by cell intercalation

2000 • 504 citations

Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

2000 • 497 citations

Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements

2002 • 491 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail

2001 • 487 citations

Using GFP in FRET-based applications

1999 • 482 citations

Protein kinase CK2: a challenge to canons

2002 • 470 citations

Social Interaction and Sensorimotor Gating Abnormalities in Mice Lacking Dvl1

1997 • 466 citations

Casein kinase I transduces Wnt signals

1999 • 443 citations

Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling

2002 • 437 citations

Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling

2001 • 433 citations

Planar Signaling and Morphogenesis in Drosophila

2002 • 428 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

1999 • 423 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

1994 • 407 citations

Analysis of Dishevelled signalling pathways during Xenopus development

1996 • 402 citations

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

1999 • 396 citations

The dishevelled protein is modified by wingless signaling in Drosophila.

1995 • 389 citations

Protein kinase CK2 and its role in cellular proliferation, development and pathology

1999 • 388 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

1994 • 379 citations

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos

2001 • 373 citations

A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

1989 • 367 citations

Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

1999 • 365 citations

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

2001 • 355 citations

The wingless signalling pathway and the patterning of the wing margin in Drosophila

1994 • 354 citations

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex

1999 • 345 citations

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

1994 • 335 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

EPS8 and E3B1 transduce signals from Ras to Rac

1999 • 329 citations

Components of wingless signalling in Drosophila

1994 • 326 citations

Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification

2001 • 324 citations

Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing

2001 • 323 citations

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus

1998 • 321 citations

Van Gogh: A New Drosophila Tissue Polarity Gene

1998 • 317 citations

strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila

1998 • 310 citations

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

2002 • 308 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

1998 • 294 citations

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

2000 • 291 citations

Dishevelled Proteins Lead to Two Signaling Pathways

1999 • 291 citations

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

2000 • 288 citations

Negative regulation of Armadillo, a Wingless effector in Drosophila

1997 • 285 citations

The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs

1999 • 275 citations

Dishevelled: at the crossroads of divergent intracellular signaling pathways

1999 • 267 citations

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

1999 • 267 citations

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

1999 • 260 citations

Frizzled-7 signalling controls tissue separation during Xenopus gastrulation

2001 • 259 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

2001 • 256 citations

Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription

1999 • 251 citations

Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer

2000 • 250 citations

Casein kinase 2associates with and phosphorylates Dishevelled

1997 • 249 citations

G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf Pathway

2001 • 248 citations

Dapper, a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation

2002 • 243 citations

Role of Rho family GTPases in epithelial morphogenesis

2002 • 238 citations

The planar polarity gene strabismus regulates convergent extension movements in Xenopus

2002 • 233 citations

The Planar Cell Polarity Gene Strabismus Regulates Convergence and Extension and Neural Fold Closure in Xenopus

2002 • 232 citations

Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1

2002 • 230 citations

frizzled regulates mirror-symmetric pattern formation in the Drosophila eye

1995 • 229 citations

Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

2002 • 224 citations

naked cuticle encodes an inducible antagonist of Wnt signalling

2000 • 221 citations

Regulation of G Protein-Coupled Receptor Kinases

2000 • 213 citations

Multiple functions of segment polarity genes in Drosophila

1987 • 212 citations

XenopusDishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis

2001 • 212 citations

Casein kinase Iɛ in the Wnt pathway: Regulation of β-catenin function

1999 • 211 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

Structural basis of the Axin–adenomatous polyposis coli interaction

2000 • 203 citations

TCF: Lady Justice Casting the Final Verdict on the Outcome of Wnt Signalling

2002 • 203 citations

Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin

1999 • 200 citations

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

2002 • 199 citations

FH proteins as cytoskeletal organizers

1998 • 195 citations

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation

2001 • 194 citations

Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells

2000 • 193 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 185 citations

Drosophila Apc2 Is a Cytoskeletally-Associated Protein That Regulates Wingless Signaling in the Embryonic Epidermis

1999 • 183 citations

Notch is required for wingless signaling in the epidermis of Drosophila

1994 • 179 citations

Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.

1993 • 179 citations

dishevelled is a component of the frizzled signaling pathway in Drosophila

1995 • 176 citations

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos

1993 • 172 citations

Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled

2002 • 166 citations

Gibberellins Signal Nuclear Import of PHOR1, a Photoperiod-Responsive Protein with Homology to Drosophila armadillo

2001 • 166 citations

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

2001 • 165 citations

naked cuticle targets dishevelled to antagonize Wnt signal transduction

2001 • 158 citations

The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo

1992 • 157 citations

Pleckstrin's repeat performance: a novel domain in G-protein signaling?

1996 • 155 citations

Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

2001 • 152 citations

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.

2000 • 151 citations

Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates

1999 • 148 citations

Characterization of Mouse Dishevelled (Dvl) Proteins in Wnt/Wingless Signaling Pathway

1999 • 148 citations

Asymmetric Localization of Frizzled and the Determination of Notch-Dependent Cell Fate in the Drosophila Eye

2002 • 147 citations

Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ

2001 • 143 citations

Vertebrate Proteins Related to Drosophila Naked Cuticle Bind Dishevelled and Antagonize Wnt Signaling

2001 • 140 citations

Drosophila par-1 is required for oocyte differentiation and microtubule organization

2001 • 137 citations

The making of a maggot: patterning the Drosophila embryonic epidermis

1994 • 134 citations

Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A

2002 • 133 citations

Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo

1999 • 133 citations

Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

1997 • 130 citations

Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction

2002 • 126 citations

The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans

2002 • 124 citations

Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein

2001 • 122 citations

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling

1999 • 122 citations

The Atypical Cadherin Flamingo Links Frizzled and Notch Signaling in Planar Polarity Establishment in the Drosophila Eye

2002 • 121 citations

Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε

2001 • 120 citations

βArrestins

2001 • 118 citations

wingless refines its own expression domain on the Drosophila wing margin

1996 • 116 citations

Drosophila wingless generates cell type diversity among engrailed expressing cells

1992 • 116 citations

Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription

2000 • 116 citations

Identification of the Axin and Frat Binding Region of Glycogen Synthase Kinase-3

2002 • 113 citations

A Mutational Analysis of dishevelled in Drosophila Defines Novel Domains in the Dishevelled Protein as Well as Novel Suppressing Alleles of axin

2002 • 112 citations

Frodo interacts with Dishevelled to transduce Wnt signals

2002 • 112 citations

The Casein Kinase I Family in Wnt Signaling

2001 • 111 citations

Protein kinase CK2: signaling and tumorigenesis in the mammary gland.

2001 • 110 citations

A Positive Role for the PP2A Catalytic Subunit in Wnt Signal Transduction

2000 • 108 citations

Colocalization and Redistribution of Dishevelled and Actin during WNT-Induced Mesenchymal Morphogenesis

2000 • 101 citations

Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction

2000 • 97 citations

Divide and conquer: pattern formation in Drosophila embryonic epidermis

2001 • 94 citations

Untitled

2001 • 92 citations

The domineering non-autonomy of frizzled and Van Gogh clones in the Drosophila wing is a consequence of a disruption in local signaling

2000 • 90 citations

The Regulation of Glycogen Synthase Kinase-3 Nuclear Export by Frat/GBP

2002 • 89 citations

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain

2000 • 81 citations

β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

2001 • 78 citations

Human Dishevelled Genes Constitute a DHR-Containing Multigene Family

1997 • 76 citations

wingless signaling in the Drosophila eye and embryonic epidermis

1996 • 76 citations

Domains of Axin and Disheveled Required for Interaction and Function in Wnt Signaling

2000 • 72 citations

Par-1 regulates stability of the posterior determinant Oskar by phosphorylation

2002 • 71 citations

Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development

2001 • 69 citations

Inhibition of the Wnt Signaling Pathway by the PR61 Subunit of Protein Phosphatase 2A

2001 • 68 citations

Functional Domains of Axin

1999 • 67 citations

Casein Kinase I: From Obscurity to Center Stage

2001 • 67 citations

Cholesterol Bodies in Soils: Phytosterol

1911 • 65 citations

Glycogen Synthase Kinase-3β Mutagenesis Identifies a Common Binding Domain for GBP and Axin

2002 • 62 citations

Casein Kinase I: From Obscurity to Center Stage

2001 • 58 citations

The Role of Maternal Axin in Patterning the Xenopus Embryo

2001 • 58 citations

Dorsal downregulation of GSK3β by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos

2000 • 55 citations

The Casein Kinase I Family: Roles in Morphogenesis

2001 • 50 citations

Molecular Cloning and Characterization of FRAT2, Encoding a Positive Regulator of the WNT Signaling Pathway

2001 • 49 citations

Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled

1995 • 48 citations

Dickkopf1 and the Spemann-Mangold head organizer.

2001 • 45 citations

Differential Molecular Assemblies Underlie the Dual Function of Axin in Modulating the Wnt and JNK Pathways

2001 • 42 citations

In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3

1999 • 40 citations

Identification of EPS8 as a Dvl1-Associated Molecule

1999 • 22 citations

Wnt signaling: The Naked truth?

2001 • 20 citations

Effects of rat Axin domains on axis formation in Xenopus embryos

2000 • 12 citations