Altered localization ofDrosophilaSmoothened protein activates Hedgehog signal transduction

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

2002 • 1,442 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1999 • 1,236 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

1995 • 505 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

Argosomes

2001 • 413 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

2001 • 368 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Role of the Small GTPase RAB7 in the Late Endocytic Pathway

1997 • 302 citations

A novel role for Rab5–GDI in ligand sequestration into clathrin-coated pits

1998 • 273 citations

N-Glycans Mediate the Apical Sorting of a Gpi-Anchored, Raft-Associated Protein in Madin-Darby Canine Kidney Cells

1999 • 247 citations

Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle

1997 • 221 citations

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

1994 • 194 citations

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

2001 • 191 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

Transducing the Hedgehog Signal

2000 • 186 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

Hedgehog signal transduction: recent findings

2002 • 183 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Intracellular transport of GPI-anchored proteins

2000 • 167 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Seven-transmembrane receptors: crystals clarify

2002 • 158 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 • 141 citations

Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo

1999 • 133 citations

In Vivo Functions of the Patched Protein

2000 • 128 citations

Identification of a Tetrameric Hedgehog Signaling Complex

2000 • 111 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

Salivary gland development in Drosophila melanogaster

2000 • 103 citations

Smoothened Activates Gαi-mediated Signaling in Frog Melanophores

2000 • 101 citations

GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth

1994 • 96 citations

Multidrug permeases and subcellular cholesterol transport

2001 • 96 citations

The Effect of Pertussis Toxin on Zebrafish Development: A Possible Role for Inhibitory G-Proteins in Hedgehog Signaling

1998 • 73 citations

The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.

1997 • 53 citations

Untitled

1997 • 44 citations

A Different Intracellular Distribution of a Single Reporter Protein Is Determined at Steady State by KKXXor KDEL Retrieval Signals

1999 • 21 citations

A Drosophila gene that encodes a member of the protein disulfide isomerase/phospholipase C-α family

1995 • 15 citations

Hedgehog Signaling in Animal Development and Human Disease

2000 • 11 citations