Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis

1999 • 2,521 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Feedback control of intercellular signalling in development

2000 • 535 citations

Specification of neuronal fates in the ventral neural tube

2001 • 530 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

Establishment of developmental precision and proportions in the early Drosophila embryo

2002 • 496 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning

2002 • 463 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Wingless gradient formation in the Drosophila wing

2000 • 437 citations

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing

1997 • 416 citations

Argosomes

2001 • 413 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

Proximal–distal axis formation in the Drosophila leg

1997 • 368 citations

Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing

1998 • 331 citations

Positional information revisited

1989 • 322 citations

Antagonistic Interactions Between Wingless and Decapentaplegic Responsible for Dorsal-Ventral Pattern in the Drosophila Leg

1996 • 322 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Transducing the Dpp Morphogen Gradient in the Wing of Drosophila

1999 • 280 citations

The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation

1999 • 262 citations

HSPG Modification by the Secreted Enzyme Notum Shapes the Wingless Morphogen Gradient

2002 • 238 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila

1999 • 188 citations

Problems and paradigms: Morphogens and pattern formation

1997 • 184 citations

Mechanisms for Positional Signalling by Morphogen Transport: a Theoretical Study

1998 • 181 citations

Dual functions of wingless in the Drosophila leg imaginal disc

1995 • 167 citations

Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless

2000 • 132 citations

decapentaplegicOverexpression AffectsDrosophilaWing and Leg Imaginal Disc Development andwinglessExpression

1996 • 131 citations

Negative Feedback Mechanisms and Their Roles during Pattern Formation

1999 • 127 citations

Wingful, an extracellular feedback inhibitor of Wingless

2002 • 121 citations

Formation of morphogen gradients in the Drosophila wing

1999 • 115 citations

Regulating morphogen gradients in the Drosophila wing

2002 • 97 citations

Activin as a morphogen in Xenopus mesoderm induction

1999 • 84 citations

On the range of Hedgehog signaling

2000 • 62 citations

Wingless Capture by Frizzled and Frizzled2 in Drosophila Embryos

2001 • 24 citations

Hedgehog Signalling: Pulling Apart Patched and Smoothened

2002 • 8 citations