Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Rab proteins as membrane organizers

2001 • 3,320 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia

1990 • 669 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2

1997 • 371 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling

2000 • 217 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

Structural conservation of Notch receptors and ligands

1998 • 201 citations

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

2003 • 200 citations

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

2001 • 191 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

1990 • 182 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

2004 • 165 citations

Hrs mediates downregulation of multiple signalling receptors in Drosophila

2003 • 143 citations

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

2000 • 141 citations

Directionality of Wingless protein transport influences epidermal patterning in the Drosophila embryo

1999 • 133 citations

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

1994 • 111 citations

Posttranscriptional Regulation of Smoothened Is Part of a Self-Correcting Mechanism in the Hedgehog Signaling System

2000 • 108 citations

Cholesterol modification of Hedgehog family proteins

2002 • 100 citations

Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals

1999 • 100 citations

Divide and conquer: pattern formation in Drosophila embryonic epidermis

2001 • 94 citations

Cholesterol modification of Hedgehog family proteins

2002 • 84 citations

Hox genes differentially regulate Serrate to generate segment-specific structures

1999 • 54 citations

patched Overexpression Causes Loss of wingless Expression in Drosophila Embryos

1994 • 32 citations