Interleukin 2: from immunostimulation to immunoregulation and back again

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

T Cell Anergy

2003 • 1,418 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

2006 • 1,081 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells

2002 • 877 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes

2006 • 843 citations

DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS

2006 • 816 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

2005 • 598 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2005 • 473 citations

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1998 • 447 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

2003 • 384 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis

2004 • 364 citations

Cytokines and immunodeficiency diseases: critical roles of the γ_c‐dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

2004 • 357 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Long-term culture of human antigen-specific cytotoxic T-cell lines.

1978 • 220 citations

Epigenetic Remodeling of theIL-2andIFN-γ Loci in Memory CD8 T Cells Is Influenced by CD4 T Cells

2006 • 206 citations

Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.

1997 • 192 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection

2006 • 186 citations

Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

2001 • 183 citations

Differential role of IL‐2R signaling for CD8⁺ T cell responses in acute and chronic viral infections

2007 • 179 citations

Cutting Edge: Transpresentation of IL-15 by Bone Marrow-Derived Cells Necessitates Expression of IL-15 and IL-15Rα by the Same Cells

2004 • 175 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells

2007 • 166 citations

Differential regulation of T-cell growth by IL-2 and IL-15

2006 • 158 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

Lymphocyte activating factor promotes T-cell growth factor production by cloned marine lymphoma cells

1980 • 146 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

Recall Proliferation Potential of Memory CD8+ T Cells and Antiviral Protection

2005 • 134 citations

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8 ⁺ T cell functions during chronic viral infection

2007 • 131 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter

2005 • 125 citations

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

2007 • 121 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes

2001 • 114 citations

Naive CD8+ T cells differentiate into protective memory-like cells after IL-2–anti–IL-2 complex treatment in vivo

2007 • 108 citations

Normal Regulatory α/β T Cells Effectively Eliminate Abnormally Activated T Cells Lacking the Interleukin 2 Receptor β in Vivo

1999 • 99 citations

IL-2 and autoimmune disease

2002 • 93 citations

The Dual Role of IL-2 in the Generation and Maintenance of CD8+ Memory T Cells

2000 • 87 citations

The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.

1999 • 87 citations

Broad Programming by IL-2 Receptor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation of Antigen-Activated T Cells

2001 • 85 citations

Interleukin-2 Is Indispensable for Development of Immunological Self-Tolerance

1996 • 74 citations

The Role of the Common Cytokine Receptor γ-Chain in Regulating IL-2-Dependent, Activation-Induced CD8+ T Cell Death

1999 • 67 citations

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

1995 • 66 citations

Thymic selection and peptide‐induced activation of T cell receptor‐transgenic CD8 T cells in interleukin‐2‐deficient mice

1994 • 64 citations

The control of T cell activation vs. tolerance

2003 • 62 citations

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors

2003 • 58 citations

Balancing protective immunity and immunopathology

2002 • 58 citations

Cutting Edge: Distinct Roles for T Help and CD40/CD40 Ligand in Regulating Differentiation of Proliferation-Competent Memory CD8+ T Cells

2004 • 49 citations

Antigen Is Required for the Activation of Effector Activities, whereas Interleukin 2 Is Required for the Maintenance of Memory in Ovalbumin-specific, CD8+ Cytotoxic T Lymphocytes

1998 • 48 citations

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells

2003 • 47 citations

T lymphocyte‐mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin‐2 receptor

1994 • 16 citations